Salicyl alcohol
Based on 1 Customer Validation
Salicyl alcohol (2-Hydroxybenzyl alcohol; Saligenin) is a phenolic alcohol-type topical anesthetic and strong sensitizer with antiseptic, antibacterial and antipyretic activities. Salicyl alcohol serves as a precursor for salicin synthesis. Salicyl alcohol induces contact dermatitis and eczematous skin reactions, and is a well-known allergen identified in phenolic resins. Salicyl alcohol is isolated from the barks of European aspen (Populus tremula), rowan (Sorbus aucuparia) and willow (Salix spp.). Salicyl alcohol is used in studies related to allergic contact dermatitis.
For research use only. We do not sell to patients.
- Purity: 99.26%
- CAS No.: 90-01-7
- Formula: C7H8O2
- Molecular Weight:124.14
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Anti-Infection Compound Library
HY-L002
-
Natural Product Library
HY-L021
-
Antibacterial Compound Library
HY-L049
-
Medicine Food Homology Compound Library
HY-L055
-
Phenols Library
HY-L057
-
Traditional Chinese Medicine Active Compound Library
HY-L065
-
FDA Approved & Pharmacopeial Drug Library
HY-L066
-
Microbial Metabolite Library
HY-L084
-
Food-Sourced Compound Library
HY-L094
-
Human Metabolite Library
HY-L123
-
MCE Bioactive Compound Library
HY-L001V
-
Natural Product Library Plus
HY-L021P
-
Natural Product and Natural Product-Like Compound Library
HY-L021M
-
Tibetan Medicine Compound Library
HY-L191
-
PBCRBS Traditional Chinese Medicine Compound Library
HY-L193
-
RO5 Drug-like Natural Product Library
HY-L200
-
High-Throughput Bioactive Compound Library
HY-L205
-
High-Throughput Natural Product Library
HY-L206
-
Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library
HY-L209
-
Mass Spectrometry Human Metabolite Library
HY-L215
-
Mouse Metabolite Compound Library
HY-L217
-
Diarrhea-Related Traditional Chinese Medicine Active Compound Library
HY-L224
-
Mongolian Medicine Compound Library
HY-L238
-
Chinese Baijiu Compound Library
HY-L241
-
Tonifying Traditional Chinese Medicine Monomer Compound Library
HY-L246
-
Mass Spectrometry Natural Product Library
HY-L262
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | CC50 |
>250 μM
Compound: 6c
|
The cytotoxicity was measured on wild type CEM/O cells.
The cytotoxicity was measured on wild type CEM/O cells.
|
[PMID: 9554875] |
| CCRF-CEM | EC50 |
>250 μM
Compound: 6c
|
Antiviral activity was measured on HIV-1 in wild-type CEM/O cells
Antiviral activity was measured on HIV-1 in wild-type CEM/O cells
|
[PMID: 9554875] |
| CCRF-CEM | EC50 |
>250 μM
Compound: 6c
|
Antiviral activity was measured on HIV-2 in wild-type CEM/O cells
Antiviral activity was measured on HIV-2 in wild-type CEM/O cells
|
[PMID: 9554875] |
| HEK293 | IC50 |
>15 mM
Compound: Salicyl alcohol
|
Cytotoxicity against HEK293 cells harboring pendrin P123S mutant after 72 hrs by MTT assay
Cytotoxicity against HEK293 cells harboring pendrin P123S mutant after 72 hrs by MTT assay
|
[PMID: 28341401] |
Salicyl alcohol (72 h) is produced at 264.2 mg/L as a byproduct by engineered E. coli BW25113 (F') strain XJ12 after 72 h of de novo fermentation for gentisyl alcohol[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 90-01-7
-
Appearance Solid
-
Molecular Weight 124.14
-
Formula C7H8O2
-
Color White to off-white
-
SMILES
OCC1=CC=CC=C1O
-
Synonyms
2-Hydroxybenzyl alcohol; Saligenin
-
Structure Classification
-
Initial Source
Escherichia coli
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : ≥ 100 mg/mL (805.54 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 33.33 mg/mL (268.49 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 66.67 mg/mL (537.05 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
[1]. Shen X, et al. Establishment of Novel Biosynthetic Pathways for the Production of Salicyl Alcohol and Gentisyl Alcohol in Engineered Escherichia coli. ACS Synth Biol. 2018;7(4):1012-1017. [Content Brief]
[2]. Aalto-Korte K, et al. Allergic contact dermatitis from salicyl alcohol and salicylaldehyde in aspen bark (Populus tremula). Contact Dermatitis. 2005;52(2):93-95. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 8.0554 mL | 40.2771 mL | 80.5542 mL | 201.3855 mL |
| 5 mM | 1.6111 mL | 8.0554 mL | 16.1108 mL | 40.2771 mL | |
| 10 mM | 0.8055 mL | 4.0277 mL | 8.0554 mL | 20.1386 mL | |
| 15 mM | 0.5370 mL | 2.6851 mL | 5.3703 mL | 13.4257 mL | |
| 20 mM | 0.4028 mL | 2.0139 mL | 4.0277 mL | 10.0693 mL | |
| 25 mM | 0.3222 mL | 1.6111 mL | 3.2222 mL | 8.0554 mL | |
| 30 mM | 0.2685 mL | 1.3426 mL | 2.6851 mL | 6.7129 mL | |
| 40 mM | 0.2014 mL | 1.0069 mL | 2.0139 mL | 5.0346 mL | |
| 50 mM | 0.1611 mL | 0.8055 mL | 1.6111 mL | 4.0277 mL | |
| 60 mM | 0.1343 mL | 0.6713 mL | 1.3426 mL | 3.3564 mL | |
| 80 mM | 0.1007 mL | 0.5035 mL | 1.0069 mL | 2.5173 mL | |
| 100 mM | 0.0806 mL | 0.4028 mL | 0.8055 mL | 2.0139 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Salicyl alcohol Related Classifications
HY-B1419 Related Classifications
Powered by Bioz
- Salicyl alcohol
- 90-01-7
- 2-Hydroxybenzyl alcohol
- Saligenin
- Drug Intermediate
- Bacterial
- E. coli BW25113 (F') strain XJ07
- Populus tremula
- Salix spp.
- allergic contact dermatitis
- contact allergy
- phenol-formaldehyde resins
- eczematous skin reactions
- E. coli BW25113 (F') strain XJ02
- Sorbus aucuparia
- E. coli BW25113 (F') strain XJ01
- Inhibitor
- inhibitor
- inhibit