-
ADC Payloads Related Products (217)
Related Products (217)
-
10-Acetyl docetaxel
0 ImagesSynonyms: PNU-10138310-Acetyl docetaxel (PNU-101383) is an analog of Docetaxel (HY-B0011), with anticancer activity. 10-Acetyl docetaxel is a microtubule disassembly inhibitor, with antimitotic activity.
-
Glucocorticoid receptor agonist-1
0 ImagesCat. No.: HY-131974CAS No.: 2166375-82-0Glucocorticoid receptor agonist-1 is a potent glucocorticoid receptor agonist with an IC50 of 2.8 nM extracted from patent WO2017210471A1, compound 41.
-
NMT-IN-7
0 ImagesNMT-IN-7 is a N-myristoyl transferase (NMT) inhibitor, with IC50s of 2.1 nM for HsNMT1M, 0.6 nM for SU-DHL-10 cell. NMT-IN-7 can be used as a ADC cytotoxin.
-
SN-38 (Standard)
0 ImagesSynonyms: 7-Ethyl-10-hydroxycamptothecin (Standard)SN-38 (Standard) is the analytical standard of SN-38. This product is intended for research and analytical applications. SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254).
-
Paclitaxel-d5
0 ImagesPaclitaxel-d5 is a deuterium-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization.
-
Monomethyl auristatin E (GMP)
0 ImagesCat. No.: HY-15162GCAS No.: 474645-27-7Synonyms: MMAE (GMP); SGD-1010 (GMP); Vedotin (GMP)Monomethyl auristatin E (MMAE) (GMP) is Monomethyl auristatin E (HY-15162) produced by using GMP guidelines. Monomethyl auristatin E is a tubulin polymerization inhibitor.
-
ZD06519
0 ImagesSynonyms: 7-Hydroxyethyl carbamate-(10Me-11F-Camptothecin)ZD06519 (7-Hydroxyethyl carbamate-(10Me-11F-Camptothecin)) is a camptothecin (HY-16560) analogue and a topoisomerase I inhibitor. ZD06519 is an ADC cytotoxin with a strong bystander effect, inhibiting a variety of malignancies such as HER2-positive and FRα-overexpressing tumors. ZD06519 inhibits DNA cleavage, relaxation, and reconnection processes, inducing tumor cell death. ZD06519 can be used for ADC synthesis and cancer research.
-
PBD-monoamide
0 ImagesCat. No.: HY-161252CAS No.: 2093165-00-3PBD-monoamide, a modified PBD (pyrrolobenzodiazepine) dimer, is an ADC Cytotoxin. PBD-monoamide can be used for synthesis of DHES0815A (an HER2 ADC). PBD-monoamide has DNA-binding activity and reduces cell viability.
-
Mal-Exatecan
0 ImagesMal-Exatecan is a Mal (Maleimide) modified Exatecan (HY-13631), a DNA topoisomerase I (topoisomerase I) inhibitor.
-
SC209
0 ImagesSynonyms: 3-Aminophenyl HemiasterlinSC209 (3-Aminophenyl Hemiasterlin) is a 3-aminophenyl hemiasterlin derivative that serves as a cytotoxin for ADCs, targeting tubulin. SC209 has reduced potential for drug efflux via P-glycoprotein 1 drug pump compared with other tubulin-targeting payloads. SC209 exhibits antitumor activity and can be used in the synthesis of ADC molecules.
-
FL118-14-Propanol-d5
0 ImagesCat. No.: HY-156856SSynonyms: YL0010014-d5FL118-14-Propanol-d5 is the deuterium labeled FL118-14-Propanol (HY-156856). FL118-14-Propanol is a FL118 derivative. FL118-14-Propanol synthesized ADC molecule has good anti-tumor effect in mice.
-
Maytansinol
0 ImagesSynonyms: Ansamitocin P-0
-
N-Acetyl-Calicheamicin
0 ImagesSynonyms: N-Acetyl-Calicheamicin γ; N-Acetyl-γ-calicheamicinN-Acetyl-Calicheamicin (N-Acetyl-Calicheamicin γ), an enediyne anti-tumor antibiotic, is an ADC cytotoxin. N-Acetyl-Calicheamicin can induce DNA damage, and can be used in the synthesis of ADC.
-
(R)-Benzyl 2-cyclopropyl-2-hydroxyacetate
0 Images(R)-Benzyl 2-cyclopropyl-2-hydroxyacetate can be used in the synthesis of pyrrolidines, a relevant molecule for ADC applications.
-
Dexamethasone (GMP)
0 ImagesDexamethasone (Hexadecadrol) (GMP) is Dexamethasone (HY-14648) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Dexamethasone is an agonist of glucocorticoid receptor.
-
Glucocorticoid receptor agonist-2
0 ImagesCat. No.: HY-148435CAS No.: 2166378-92-1Glucocorticoid receptor agonist-2 (compound 21) is an glucocorticoid receptor agonist with an IC50 value of 6.6 nM. Glucocorticoid receptor agonist-2 can be used to synthesize anti-inflammatory ADC molecules. Glucocorticoid receptor agonist-2 is an active reference of ABBV-3373.
-
Tubulysin
0 ImagesTubulysin is a microtubule destabilizer that binds to the β-tubulin peptide site adjacent to the vinca alkaloid binding site and inhibits tubulin polymerization. Tubulysin induces apoptosis and exhibits antiproliferative activity against a variety of human cancer cells, including multidrug-resistant strains. Tubulysin can be conjugated to antibodies via a disulfide-containing quaternary ammonium linker for ADC synthesis. Tubulysin is applicable to tumor-related research.
