2. Antibody-drug Conjugate/ADC Related
  3. ADC Cytotoxin
  4. PBD dimer-2

PBD dimer-2 (compound 2c) is a C8-linked pyrrolobenzodiazepine dimer. PBD dimer-2 can span an extra base pair and cross-link the 5′-Pu-GA(T/A)TC-Py sequence. PBD dimer-2 can be used as a payload for antibody–agent conjugates (ADCs), and it can be used for the research of cancer.

For research use only. We do not sell to patients.

PBD dimer-2 Chemical Structure

PBD dimer-2 Chemical Structure

CAS No. : 145325-57-1

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5 mg USD 680 In-stock
10 mg USD 1100 In-stock
25 mg USD 2250 In-stock
50 mg USD 3500 In-stock
100 mg USD 5500 In-stock
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Based on 1 publication(s) in Google Scholar

PBD dimer-2 Related Antibodies

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Auristatin Calicheamicins Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

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Description

PBD dimer-2 (compound 2c) is a C8-linked pyrrolobenzodiazepine dimer. PBD dimer-2 can span an extra base pair and cross-link the 5′-Pu-GA(T/A)TC-Py sequence. PBD dimer-2 can be used as a payload for antibody–agent conjugates (ADCs), and it can be used for the research of cancer[1][2].

Molecular Weight

560.64

Formula

C31H36N4O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=CC(OC)=C(OCCCCCOC3=C(C=C4C(N=C[C@@]5([H])N(CCC5)C4=O)=C3)OC)C=C2N=C[C@@]6([H])N1CCC6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 130 mg/mL (231.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7837 mL 8.9184 mL 17.8368 mL
5 mM 0.3567 mL 1.7837 mL 3.5674 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.03%

COA (248 KB) HNMR (523 KB) NP-HPLC (493 KB) LCMS (99 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7837 mL 8.9184 mL 17.8368 mL 44.5919 mL
5 mM 0.3567 mL 1.7837 mL 3.5674 mL 8.9184 mL
10 mM 0.1784 mL 0.8918 mL 1.7837 mL 4.4592 mL
15 mM 0.1189 mL 0.5946 mL 1.1891 mL 2.9728 mL
20 mM 0.0892 mL 0.4459 mL 0.8918 mL 2.2296 mL
25 mM 0.0713 mL 0.3567 mL 0.7135 mL 1.7837 mL
30 mM 0.0595 mL 0.2973 mL 0.5946 mL 1.4864 mL
40 mM 0.0446 mL 0.2230 mL 0.4459 mL 1.1148 mL
50 mM 0.0357 mL 0.1784 mL 0.3567 mL 0.8918 mL
60 mM 0.0297 mL 0.1486 mL 0.2973 mL 0.7432 mL
80 mM 0.0223 mL 0.1115 mL 0.2230 mL 0.5574 mL
100 mM 0.0178 mL 0.0892 mL 0.1784 mL 0.4459 mL
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PBD dimer-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PBD dimer-2145325-57-1PBD dimer2PBD dimer 2ADC CytotoxinADC Payloadpyrrolobenzodiazepine dimerC8base paircross-linkDNA sequenceInhibitorinhibitorinhibit

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