1. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage Anti-infection
  2. ADC Cytotoxin DNA/RNA Synthesis Antibiotic Bacterial
  3. N-Acetyl-Calicheamicin

N-Acetyl-Calicheamicin  (Synonyms: N-Acetyl-Calicheamicin γ; N-Acetyl-γ-calicheamicin)

Cat. No.: HY-19791 Purity: 99.17%
COA Handling Instructions

N-Acetyl-Calicheamicin (N-Acetyl-Calicheamicin γ), an enediyne anti-tumor antibiotic, is an ADC cytotoxin. N-Acetyl-Calicheamicin can induce DNA damage, and can be used in the synthesis of ADC.

For research use only. We do not sell to patients.

N-Acetyl-Calicheamicin Chemical Structure

N-Acetyl-Calicheamicin Chemical Structure

CAS No. : 108212-76-6

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1 mg USD 600 In-stock
5 mg USD 1500 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

N-Acetyl-Calicheamicin (N-Acetyl-Calicheamicin γ), an enediyne anti-tumor antibiotic, is an ADC cytotoxin. N-Acetyl-Calicheamicin can induce DNA damage, and can be used in the synthesis of ADC[1].

In Vitro

N-Acetyl-Calicheamicin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1]
Once the ADC is internalized and degraded in the lysosome, the potent calicheamicin derivative, N-Acetyl-Calicheamicin (N-Acetyl-Calicheamicin γ), is then activated by reduction of the dimethyl disulfide trigger in the cytosol to form the potent enediyne diradical capable of inducing DNA strand breaks[2]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1410.39

Formula

C57H76IN3O22S4

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@](CC1=O)(C#C/C=C\C#C2)/C(C([C@H]2O[C@@](O[C@H](C)[C@@H](NO[C@H](O[C@H](C)[C@H]3SC(C(C(C)=C(I)C(O[C@H](O[C@@H](C)[C@H](O)[C@H]4OC)[C@@H]4O)=C5OC)=C5OC)=O)C[C@@H]3O)[C@@H]6O)([H])[C@@H]6O[C@@](OC[C@@H]7N(CC)C(C)=O)([H])C[C@@H]7OC)=C1NC(OC)=O)=C/CSSSC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (70.90 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7090 mL 3.5451 mL 7.0902 mL
5 mM 0.1418 mL 0.7090 mL 1.4180 mL
10 mM 0.0709 mL 0.3545 mL 0.7090 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.39%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
N-Acetyl-Calicheamicin
Cat. No.:
HY-19791
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