2. Signaling Pathways
  3. PI3K/Akt/mTOR
  4. Akt
  5. Akt1 Isoform
  6. Akt1 Activator

Akt1 Activator

Akt1 Activator (1):

Cat. No. Product Name Effect Purity
  • HY-W073128
    Perfluorotetradecanoic acid
    		Activator 98.0%
    Perfluorotetradecanoic acid (PFTeDA) is an orally active perfluoroalkyl substance. Perfluorotetradecanoic acid directly binds to the ligand-binding domain of purified hPPARγ, with a Kd value of 157.8 μM. Perfluorotetradecanoic acid significantly reduces the activity of the SIRT1/PGC1α and AMPK signaling pathways while stimulating the activity of the AKT1/mTOR signaling pathway. Perfluorotetradecanoic acid significantly upregulates the expression of corticosterone biosynthesis genes. Perfluorotetradecanoic acid increases ROS levels and promotes Apoptosis. Perfluorotetradecanoic acid impairs Leydig cell function and male reproductive endocrine function in adult male rats.