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CDK Related Products (482)
Related Products (482)
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Zotiraciclib hydrochloride
0 ImagesCat. No.: HY-15163ACAS No.: 1354567-82-0Zotiraciclib hydrochloride is a novel small molecule multi-target enzyme inhibitor with activity in inhibiting tumor growth. Zotiraciclib hydrochloride exerts its anti-tumor effect by reducing the level of Myc through inhibiting cyclin-dependent kinase 9 (CDK9). Zotiraciclib hydrochloride may be useful for inhibiting cancers that cross the blood-brain barrier. The high protein level of MCL-1 of Zotiraciclib hydrochloride is associated with survival, suggesting that it may serve as a prognostic factor and inhibitory target in further studies.
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Xylocydine
0 ImagesCat. No.: HY-118310CAS No.: 685901-63-7
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CDK7-IN-18
0 ImagesCat. No.: HY-147603CAS No.: 2765676-81-9
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IMP-Zn
0 ImagesCat. No.: HY-181923IMP-Zn is a pyrazole-hydrazone Schiff base zinc (II) complex. IMP-Zn exhibits significant antiproliferative activity against human colorectal cancer cells and induces cell cycle arrest. IMP-Zn shows stronger binding affinity than its free ligand IMP towards three cancer-related protein targets: EGFR kinase 1M17, cytochrome P450 3RUK, and CDK inhibitor 6GUE. IMP-Zn can be used in studies related to colorectal cancer.
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CDK1/CycA2 Recombinant Human Active Protein Kinase
0 ImagesCat. No.: HY-E70652CDK1 is a cyclin-dependent kinase that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. CDK4/CycD2 Recombinant Human Active Protein Kinase is an ortholog of CDK1.
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CDK-IN-11
0 ImagesCat. No.: HY-149173CAS No.: 2376876-87-6CDK-IN-11 is a heterocyclic compound that has an action of promoting cardiomyocyte maturation.
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CDK2-IN-13-d3
0 ImagesCat. No.: HY-W478102SCDK2-IN-13-d3 is the deuterium labeled CDK2-IN-13 (HY-W478102). CDK2-IN-13 (Compound 15) is a CDK2 inhibitor with an IC50 of 12 μM. CDK2-IN-13 can be used in research of cancer.
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Maleimide-PEG8-Val-Ala-PAB-SNS032
0 ImagesCat. No.: HY-161780Maleimide-Val-Ala-PAB-SNS032 is a conjugate of ADC toxin and linker. SNS032 is an inhibitor for CDK, inhibiting the cell cycle at G1/S phase and cell viability of cancer cells. Maleimide-Val-Ala-PAB is a cleavable ADC linker. Maleimide-Val-Ala-PAB-SNS032 can be utilized for the synthesis of ADC molecules.
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CLK1-IN-5
0 ImagesCat. No.: HY-184276CLK1-IN-5 is a potent and selective CLK1 inhibitor with an IC50 of 23 nM. CLK1-IN-5 can be used in the research of cancer and Alzheimer's disease.
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Chikusetsusaponin IVa methyl ester
0 ImagesCat. No.: HY-N17736CAS No.: 58546-61-5Synonyms: CMEChikusetsusaponin IVa methyl ester (CME) is a natural triterpenoid saponin compound. Chikusetsusaponin IVa methyl ester induces G0/G1 cell cycle arrest and apoptosis in colon cancer cells by inhibiting the Wnt/β-catenin signaling pathway. By inhibiting the NF-κB and AP-1 signaling pathways, Chikusetsusaponin IVa methyl ester significantly reduces the production of NO, PGE₂ and pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), and downregulates the levels of iNOS and COX-2. Chikusetsusaponin IVa methyl ester can be used in researches on colorectal cancer and inflammation.
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P18IN005 hydrochloride
0 ImagesCat. No.: HY-115893ACAS No.: 7403-44-3P18IN005 hydrochloride is a novel inhibitor of p18, exhibiting potent activity in negatively regulating haematopoietic stem cell (HSC) self-renewal. P18IN005 hydrochloride has been shown to be more effective than p27 in inhibiting HSC self-renewal in mouse models. P18IN005 hydrochloride promotes the expansion of functional HSCs in short-term cultures. P18IN005 hydrochloride serves as a valuable tool for dissecting the signaling pathways involved in stem cell self-renewal.
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Cdc7-IN-17
0 ImagesCat. No.: HY-143431CAS No.: 2253686-94-9
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Multi-target kinase inhibitor 3
0 ImagesCat. No.: HY-169216Multi-target kinase inhibitor 3 (compund 6i) is a multi-kinase target inhibitor with anticancer activity. Multi-target kinase inhibitor 3 inhibits EGFR, HER2, VEGFR-2, and CDK2 with IC50s of 0.063 μM, 0.054 μM, 0.119 μM, and 0.448 μM, respectively. Multi-target kinase inhibitor 3 has a good inhibitory effect on breast cancer cells MCF-7, with an IC50 of 6.10 μM.
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Metralindole hydrochloride
0 ImagesCat. No.: HY-124321CAS No.: 53734-79-5Metralindole hydrochloride is an inhibitor of human cyclin-dependent kinase CDK2 and human protein kinase CK2 holoenzyme. Metralindole hydrochloride shows good potential as a non-small cell lung cancer inhibitor.
