Xylocydine
Xylocydine is an inhibitor of CDK1/2, inhibiting CDK function in various apoptotic processes. Xylocydine specifically blocks CDK1 and CDK2 activity with IC50 of 1.4 nM and 61 nM, respectively. In addition, Xylocydine downregulates phosphorylated nucleolin and retinoblastoma protein levels..
For research use only. We do not sell to patients.
- CAS No.: 685901-63-7
- Formula: C12H14BrN5O5
- Molecular Weight:388.17
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
IC50: 1.4 nM (CDK1), 61 nM (CDK2)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
0.0014 μM
Compound: 2
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Inhibition of CDK1/Cyclin B in human HeLa cell extracts using histone H1 as substrate preincubated for 30 mins before substrate addition measured after 15 mins by autoradiography
Inhibition of CDK1/Cyclin B in human HeLa cell extracts using histone H1 as substrate preincubated for 30 mins before substrate addition measured after 15 mins by autoradiography
|
[PMID: 22036212] |
| HeLa | IC50 |
0.061 μM
Compound: 2
|
Inhibition of CDK2/Cyclin A2 in human HeLa cell extracts using histone H1 as substrate preincubated for 30 mins before substrate addition measured after 15 mins by autoradiography
Inhibition of CDK2/Cyclin A2 in human HeLa cell extracts using histone H1 as substrate preincubated for 30 mins before substrate addition measured after 15 mins by autoradiography
|
[PMID: 22036212] |
Chemical Information
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CAS No. 685901-63-7
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Molecular Weight 388.17
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Formula C12H14BrN5O5
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SMILES
O=C(N)C1=C(N([C@H]2O[C@@H](CO)[C@@H](O)[C@@H]2O)C3=NC=NC(N)=C31)Br
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)