Xylocydine
Xylocydine is an inhibitor of CDK1/2, inhibiting CDK function in various apoptotic processes. Xylocydine specifically blocks CDK1 and CDK2 activity with IC50 of 1.4 nM and 61 nM, respectively. In addition, Xylocydine downregulates phosphorylated nucleolin and retinoblastoma protein levels..
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- CAS. Nr.: 685901-63-7
- Formel: C12H14BrN5O5
- Molecular Weight:388.17
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
IC50 & Target
IC50: 1.4 nM (CDK1), 61 nM (CDK2)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
0.0014 μM
Compound: 2
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Inhibition of CDK1/Cyclin B in human HeLa cell extracts using histone H1 as substrate preincubated for 30 mins before substrate addition measured after 15 mins by autoradiography
Inhibition of CDK1/Cyclin B in human HeLa cell extracts using histone H1 as substrate preincubated for 30 mins before substrate addition measured after 15 mins by autoradiography
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[PMID: 22036212] |
| HeLa | IC50 |
0.061 μM
Compound: 2
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Inhibition of CDK2/Cyclin A2 in human HeLa cell extracts using histone H1 as substrate preincubated for 30 mins before substrate addition measured after 15 mins by autoradiography
Inhibition of CDK2/Cyclin A2 in human HeLa cell extracts using histone H1 as substrate preincubated for 30 mins before substrate addition measured after 15 mins by autoradiography
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[PMID: 22036212] |
Chemical Information
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CAS. Nr. 685901-63-7
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Molecular Weight 388.17
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Formel C12H14BrN5O5
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SMILES
O=C(N)C1=C(N([C@H]2O[C@@H](CO)[C@@H](O)[C@@H]2O)C3=NC=NC(N)=C31)Br
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Xylocydine Related Classifications
HY-118310 Related Classifications
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