GPX4/CDK-IN-1
GPX4/CDK-IN-1 (Compound B9) is a dual inhibitor of GPX4 and CDK, with IC50 values of 542.5 nM, 191.2 nM and 68.1 nM for GPX4, CDK4 and CDK6, reapectively. GPX4/CDK-IN-1 shows strong cancer cell growth inhibition in vivo.
For research use only. We do not sell to patients.
- Formula: C48H45Cl2N9O7S
- Molecular Weight:962.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1.02 μM
Compound: B9
|
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
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[PMID: 38295524] |
| HCT-116 | IC50 |
0.75 μM
Compound: B9
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Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
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[PMID: 38295524] |
| HepG2 | IC50 |
1.49 μM
Compound: B9
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Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
|
[PMID: 38295524] |
| MDA-MB-231 | IC50 |
0.8 μM
Compound: B9
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
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[PMID: 38295524] |
Chemical Information
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Molecular Weight 962.90
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Formula C48H45Cl2N9O7S
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SMILES
O=C(/C1=C2NC3=C(C\2=N/OCCCNC(CCN4N=NC(COC5=C(C=C(C=C5)N(C(CCl)=O)C(C6=CC=CS6)C(NCCC7=CC=CC=C7)=O)Cl)=C4)=O)C=CC=C3)NC8=C1C=CC(OC)=C8
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GPX4/CDK-IN-1 Related Classifications
HY-163272 Related Classifications
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