Helicases Inhibitor
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Telomeric G4s ligand 2
0 ImagesCat. No.: HY-181850CAS No.: 3094716-52-3Telomeric G4s ligand 2 is an orally active, selective ligand of telomeric G-quadruplex (G4), with an IC50 of 0.4 μM. Telomeric G4s ligand 2 binds to dimeric telomeric G4, inhibits the activities of DHX36 and BLM helicases. Telomeric G4s ligand 2 activates cGAS-STING and TERRA-ZBP1 pathways, inducing autophagy and G2/M cell cycle arrest, and exhibits antiproliferative effects across cancer cell lines. Telomeric G4s ligand 2 can be used for the study of colorectal cancer.
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WRN-IN-19
0 ImagesCat. No.: HY-174217CAS No.: 3058652-58-4WRN-IN-19 (Compound (S)-27) is a covalent WRN helicase inhibitor, with pIC50 (0 h/4 h) = 5.4/7.5 in the DNA-unwinding 5 endpoint assays. WRN-IN-19 shows synthetic lethality in MSI-H (high microsatellite instability) cancer cells.
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Fli-1-IN-1
0 ImagesCat. No.: HY-163325ACAS No.: 3027140-81-1Fli-1-IN-1 (compound 21) is a FLI1 targeting agent that directly binds to and inhibits the EWS-FLI1 protein interaction. EWS-FLI1 can bind to RNA helicase A, and Fli-1-IN-1 inhibits EWS-FLI1 and has potential anticancer activity.
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DHX9-IN-11
0 ImagesCat. No.: HY-157605CAS No.: 2973402-91-2DHX9-IN-11 (469) is a RNA helicase DHX9 inhibitor, with an EC50 of 0.0838 μM in DHX9 cellular target engagement. Used in cancer research.
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DHX9-IN-10
0 ImagesCat. No.: HY-157608CAS No.: 2973746-79-9DHX9-IN-10 (49) is a RNA helicase DHX9 inhibitor, with an EC50 of 9.04 μM in DHX9 cellular target engagement. Used in cancer research.
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Fli-1-IN-1 fumarate
0 ImagesCat. No.: HY-163325Fli-1-IN-1 (compound 21) fumarate is a FLI1 targeting agent that directly binds to and inhibits the EWS-FLI1 protein interaction. EWS-FLI1 can bind to RNA helicase A, and Fli-1-IN-1 fumarate inhibits EWS-FLI1 and has potential anticancer activity.
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DHX9-IN-17
0 ImagesCat. No.: HY-157611CAS No.: 2973397-26-9DHX9-IN-17 (186) is a RNA helicase DHX9 inhibitor, with an EC50 of 0.161 μM in DHX9 cellular target engagement. Used in cancer research.
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DHX9-IN-18
0 ImagesCat. No.: HY-160813CAS No.: 2973395-40-1DHX9-IN-13 (Example 1) is a RNA helicase DHX9 inhibitor with an EC50 of 16.4 μM. DHX9-IN-13 exhibits biochemical infection point of 0.32 μM. DHX9-IN-13 can be used for the study of cancers.
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Cyclothialidine B
0 ImagesCat. No.: HY-N14130CAS No.: 194276-76-1Cyclothialidine B inhibits escherichia coli DNA helicases with an IC50 of 0.7 μM.
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Cyclothialidine D
0 ImagesCat. No.: HY-N14131CAS No.: 194276-78-3Cyclothialidine D inhibits escherichia coli DNA helicases with an IC50 of 0.7 μM.
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(Rac)-Adibelivir
0 ImagesCat. No.: HY-150306ACAS No.: 2137928-83-5Synonyms: (Rac)-IM-250(Rac)-Adibelivir ((Rac)-IM-250) is a blood-brain barrier-penetrant HSV helicase-primase inhibitor and metabolic stabilizer with antiviral activity. (Rac)-Adibelivir is also effective against Acyclovir (HY-17422)-resistant strains, and its deuterated structure exhibits enhanced metabolic stability, reducing the formation of hydroxylated metabolites. (Rac)-Adibelivir prolongs in vivo half-life, reduces administration dosage, improves oral bioavailability, and achieves higher brain exposure in mice. (Rac)-Adibelivir can be used in the research of herpes simplex infection, herpes encephalitis and Alzheimer's disease.
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Heliquinomycin
0 ImagesCat. No.: HY-105387CAS No.: 178182-49-5Heliquinomycin is an inhibitor of DNA helicase (Ki: 6.8 μM) and inhibits DNA and RNA synthesis. Heliquinomycin is effective against Gram-positive bacteria strains. Heliquinomycin inhibits cancer cell growth.
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Cyclothialidine E
0 ImagesCat. No.: HY-N14132CAS No.: 194276-79-4Cyclothialidine E inhibits escherichia coli DNA helicases with an IC50 of 0.7 μM.
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(R)-Adibelivir
0 ImagesSynonyms: (R)-IM-250(R)-Adibelivir ((R)-IM-250) is a blood-brain barrier-permeable HSV helicase-primase inhibitor. (R)-Adibelivir specifically inhibits the activity of the HSV UL5-UL52-UL8 helicase-primase complex. (R)-Adibelivir affects viral reactivation and significantly reduces the reactivation capacity of latent neuronal HSV reservoirs. (R)-Adibelivir can be used in studies related to herpes simplex virus infection, herpes encephalitis, neonatal herpes, and other related conditions.
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UNC11676A
0 ImagesCat. No.: HY-185893CAS No.: 3126213-85-9UNC11676A is an MDA5 ATPase inhibitor with IC50 values of 6 μM, 115 μM and 108 μM against MDA5, LGP2 and DDX1, respectively. MDA5, LGP2 and DDX1 are three human DExD/H-box RNA helicases. UNC11676A can be used in the research of Aicardi-Goutières syndrome, Singleton-Merten syndrome, systemic lupus erythematosus and Alzheimer's disease.
