Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2753)
Related Products (2753)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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ATPase-IN-5
0 ImagesCat. No.: HY-169551CAS No.: 401590-85-0ATPase-IN-5 (compound 11) is a potent inhibitor of Pma1p-ATPase, with the IC50 of 12.7 μM. ATPase-IN-5 plays an important role in anti-fungal research.
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Hypelcin A-II
0 ImagesCat. No.: HY-N14260CAS No.: 93397-16-1
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Phytoalexine
0 ImagesCat. No.: HY-N15326CAS No.: 18377-50-9Phytoalexine (Compound 8) is a phytoalexin found in wasabi with antifungal activity against fungi such as Phoma lingam and Phoma wasabiae. Phytoalexine inhibits spore germination and mycelial growth of fungi. Phytoalexine is promising for research of pesticides against plant fungal diseases.
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Oxaziclomefone
0 ImagesOxaziclomefone is a broad-spectrum pesticide with fungal activity. Oxaziclomefone effectively controls a variety of crop diseases and has significant effects against plant pathogenic fungi. Oxaziclomefone is widely used in agriculture to protect crops from diseases and improve crop yield and quality.
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FXh
0 ImagesCat. No.: HY-149738CAS No.: 2408732-55-6
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Pyrazophos (Standard)
0 ImagesCat. No.: HY-120729RCAS No.: 13457-18-6Synonyms: Curamil (Standard)Pyrazophos (Standard) is the analytical standard of Pyrazophos. This product is intended for research and analytical applications. Pyrazophos (Curamil) is a slightly systemic fungicide against the powdery mildew on crops and cereals. Pyrazophos is widely used in Greece to control diseases caused by Erysiphe spp., Sphaerotheca spp., Leveillula spp. and Oidium spp..
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Retusin (Standard)
0 ImagesSynonyms: Quercetin-3,3',4',7-tetramethylether (Standard)Retusin (Quercetin-3,3',4',7-tetramethylether) (Standard) is the analytical standard of Retusin. This product is intended for research and analytical applications. Retusin is a tyrosinase inhibitor, with IC50 values of 50.9 μM and 51.8 μM against mushroom and intracellular tyrosinase, respectively. Retusin also acts as a free radical scavenger, melanogenesis inhibitor, anti-apoptosis agent, neuroprotective agent, antiemetic, antifungal agent, and antiviral agent. Retusin scavenges ABTS•+ and DPPH• free radicals. Retusin can be used in studies related to hyperpigmentation, vomiting, Aspergillus niger infection, and COVID-19 infection.
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Stichloroside B1
0 ImagesCat. No.: HY-N7237CAS No.: 78244-74-3Stichloroside B1 is a class of antifungal triterpenoid oligosaccharide isolated from the sea cucumber Stichopus chloronotus (BRANDT).
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Inz-1
0 ImagesCat. No.: HY-116686CAS No.: 897776-15-7Inz-1 is a potent and selective mitochondrial cytochrome bc1 inhibitor for yeast (IC50=8.092 μM) over humans (IC50=45.320 μM). Inz-1 reverses Fluconazole (HY-B0101) or other triazole antifungals’ resistance in the pathogenic fungus Candida albicans.
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Penconazole-d7
0 ImagesPenconazole-d7 is the deuterium labeled Penconazole. Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats.
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Saricandin
0 ImagesCat. No.: HY-N13873CAS No.: 178494-90-1Saricandin has weak antifungal activity. Saricandin inhibits glucan synthase with an ID50 of 242.0 μg/mL.
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Elizabethin
0 ImagesCat. No.: HY-N14746CAS No.: 78361-81-6Elizabethin has antifungal activity.
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Tribenuron-methyl (Standard)
0 ImagesCat. No.: HY-111912RCAS No.: 101200-48-0Tribenuron-methyl (Standard) is the analytical standard of Tribenuron-methyl. This product is intended for research and analytical applications. Tribenuron-methyl, a sulfonylurea herbicide agent, can be used as the fungicide agent. Tribenuron-methyl plays an important role in controlling the weeds and diseases in wheat field.
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Enniatin F
0 ImagesCat. No.: HY-N14968CAS No.: 144446-20-8Enniatin F has insecticidal and antifungal activity. Enniatin F also can inhibit acyl-CoA, cholesterol acyltransferase (ACAT).
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Triforine (Standard)
0 ImagesCat. No.: HY-B2056RCAS No.: 26644-46-2Synonyms: CELA W 524 (Standard)Triforine (Standard) is the analytical standard of Triforine. This product is intended for research and analytical applications. Triforine (CELA W 524), a systemic fungicide, was shown to display a moderate to distinct fungitoxic activity in vitro towards several pathogenic and non-pathogenic fungi.
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DprE1-IN-16
0 ImagesCat. No.: HY-187512DprE1-IN-16 is a DprE1 inhibitor against Mycobacterium tuberculosis, with an IC50 value of 11.74 μM. DprE1-IN-16 binds within the catalytic site of DprE1, forming hydrogen bonds, π-cation interactions, π-sulfur interactions and hydrophobic contacts with Lys134, Gly117, Tyr415, Lys418, Cys387 and Val365. DprE1-IN-16 can be used in the research of bacterial and fungal infections as well as tuberculosis.
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Mathemycin B
0 ImagesCat. No.: HY-N14199CAS No.: 233262-38-9Mathemycin B has an inhibitory effect on pathogenic fungi. Mathemycin B inhibits the Phytophthora infestans JO8 in vitro (MIC is 7.8 μg/mL).
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10-Undecenoic acid zinc salt (Standard)
0 ImagesCat. No.: HY-B0914ARCAS No.: 557-08-4Synonyms: Zinc undecylenate (Standard)10-Undecenoic acid (zinc salt) (Standard) is the analytical standard of 10-Undecenoic acid (zinc salt). This product is intended for research and analytical applications. 10-Undecenoic acid zinc salt (Undecylenic acid zinc salt) is an antifungal agent. 10-Undecenoic acid zinc salt inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid zinc salt has neuroprotective effects. 10-Undecenoic acid zinc salt has anticancer effects on a variety of tumors. 10-Undecenoic acid zinc salt inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid zinc salt inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa.
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Azoffluxin
0 ImagesCat. No.: HY-187652CAS No.: 2883514-82-5Synonyms: CMLD012336Azoffluxin (CMLD012336) is a Cdr1 inhibitor. Azoffluxin enhances the activity of Fluconazole (HY-B0101) and other intracellular-acting antifungal agents against drug-resistant Candida. Azoffluxin is used for research on fungal efflux-mediated azole resistance and combined antifungal therapy.
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Antibiotic AB023b
0 ImagesCat. No.: HY-137085CAS No.: 141443-40-5Antibiotic AB023b is part of macrocyclic pentaene antibiotic complex, forming the main components with Antibiotic AB023a (HY-137084). Antibiotic AB023b exhibits antifungal activity against Candida albicans, and plant pathogenic fungi, Botrytis cinerea, Fusarium moniliforme and Pythium ultimum.
