Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
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Fungal 関連製品 (2768)
関連製品 (2768)
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抗体 (1)
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関連化合物スクリーニングライブラリー (1)
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Arasertaconazole
0 Images製品番号: HY-116034CAS 番号: 583057-48-1Arasertaconazole is a potent 14α-lanosterol demethylase inhibitor. Arasertaconazole has antifungal and antibacterial activity.
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Dermostatin A
0 Images製品番号: HY-N14979CAS 番号: 51053-36-2Dermostatin A is a polyene antibiotic with antifungal activity that can be used in the study of fungal infections.
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Sartorypyrone A
0 Images製品番号: HY-117872CAS 番号: 1452396-10-9別名: 20-O-Acetylsartorypyrone DSartorypyrone A (20-O-Acetylsartorypyrone D) is a monocyclic terpenoid isolated from the soil fungus Neosartorya fischeri. Sartorypyrone A exhibits in vitro growth inhibitory activity against MCF-7, NCI-H460, and A375-C5 cell lines, and has potential anticancer properties.
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PAF26
0 Images製品番号: HY-P5591純度: 98.35%PAF26 is an antimicrobial peptide against phytopathogenic fungi Penicillium digitatum, Penicillium italicum and Botrytis cinerea.
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Antifungal agent 1 (Standard)
0 Images製品番号: HY-102025RCAS 番号: 1265166-14-0Antifungal agent 1 (Standard) is the analytical standard of Antifungal agent 1 (HY-102025). This product is intended for research and analytical applications. Antifungal agent 1 is a potent antifungal agent.
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Massoia lactone (Standard)
0 Images製品番号: HY-N7435RCAS 番号: 54814-64-1別名: (±)-Massoia lactone (Standard)Massoia lactone (Standard) ((±)-Massoia lactone (Standard)) is the analytical standard of Massoia lactone (HY-N7435). This product is intended for research and analytical applications. Massoia lactone ((±)-Massoia lactone) is a natural lactone-based biosurfactant with antifungal (fungal), antibiofilm, and cytotoxic activities. Massoia lactone inhibits fungal hyphal growth and spore germination, and induces fungal cell necrosis by forming membrane pores, reducing ergosterol, elevating ROS, and causing leakage of intracellular components. Massoia lactone inhibits the viability and proliferation of tumor cells. Massoia lactone degrades the extracellular polymeric substances of polymicrobial biofilms, penetrates the biofilm matrix, inhibits the growth of planktonic oral bacteria (bacterial), and reduces surface tension through its amphiphilic properties. Massoia lactone is a low-toxicity, biodegradable food additive with a coconut cream aroma, which can be used for flavor improvement and also serves as a quality control marker for Cs-4 mycelium. Massoia lactone can be used for research on Fusarium head blight, malignant tumors, and oral polymicrobial biofilm-associated dental diseases.
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Benalaxyl (Standard)
0 Images製品番号: HY-121109RCAS 番号: 71626-11-4
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Neihumicin
0 Images製品番号: HY-N14486CAS 番号: 111451-12-8Neihumicin is resistant to beer Saccharomyces yeast ATCC 9763 and Penicillium italium Wehmer, but not to bacteria.
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SCH 39304
0 Images製品番号: HY-105110CAS 番号: 120924-80-3別名: SM-8668SM-8668 is an effective orally active antifungal agent, with median effective doses (ED50) of 0.18, 3.7, and 5.9 mg/kg for systemic candidiasis, aspergillosis, and cryptococcosis in mice, respectively. Pharmacokinetic studies in mice and rats indicate that SM-8668 has a long half-life and a high total exposure. SM-8668 can be used in anti-infective research.
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Antimicrobial agent-41
0 ImagesAntimicrobial agent-41 (Compound 19) is a thiazolidinedione derivative. Antimicrobial agent-41 exhibits excellent antioxidant activity (IC50 = 27.66 μg/mL). Antimicrobial agent-41 also exhibits antidiabetic activity (IC50 = 40.01 μg/mL). Antimicrobial agent-41 has antimicrobial activity again both bacterial and fungi.
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N,N-Bis(3-aminopropyl)dodecylamine
0 ImagesN,N-Bis(3-aminopropyl)dodecylamine is a potent fungicidal agent with remarkable activity against Aspergillus niger. N,N-Bis(3-aminopropyl)dodecylamine induces oxidative stress and regulates the activities of multiple antioxidant and mitochondrial enzymes in a concentration‑ and duration‑dependent manner. N,N-Bis(3-aminopropyl)dodecylamine disrupts fungal organelles, remodels mitochondrial morphology and impairs mitochondria‑related cellular functions. N,N-Bis(3-aminopropyl)dodecylamine can be used for the research of fungicidal mechanisms and oxidative stress in Aspergillus niger.
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Discobahamin A
0 Images製品番号: HY-P3313CAS 番号: 155547-93-6Discobahamin A is a cyclic peptide with a side chain, a 24-membered macrocyclic cyclic peptide containing an α-ketoamide functional group, and Antifungal agent. Discobahamin A exists in a new species of the deep-sea sponge genus Discodermia from the Bahamas. Discobahamin A inhibits the growth of yeast-form Candida albicans. Discobahamin A is applicable to research related to Candida albicans infections.
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NPD6433
0 Images製品番号: HY-167879ANPD6433 is a triazenyl indole with broad-spectrum activity against all screening fungal strains. NPD6433 targets the enoyl reductase domain of fatty acid synthase 1 (Fas1), covalently inhibiting its flavin mononucleotide-dependent NADPH-oxidation activity and arresting essential fatty acid biosynthesis.
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Propamocarb-d7
0 Images製品番号: HY-B2026SCAS 番号: 1398065-89-8Propamocarb-d7 is the deuterated-labeled Propamocarb (HY-B2026). Propamocarb is an orally active phenylalanine ammonia-lyase (PAL) inducer and oomycete membrane biosynthesis inhibitor that can be present in synthetic formulations. Propamocarb is used in research on blight, gut microbiota dysbiosis and metabolic disorders, cardiovascular diseases, and potato late blight.
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Coumoxystrobin
0 Images製品番号: HY-W715389CAS 番号: 850881-70-8Coumoxystrobin is a methoxyacrylate strobilurin fungicide with anti-fungal activity. Coumoxystrobin exhibits inhibitory activity against mycelial growth of Magnaporthe oryzae, increases cell membrane permeability, and reduces respiration. Coumoxystrobin shows protective activity against Magnaporthe oryzae in detached barley leaves. Coumoxystrobin reduces ATP activity of Chlorella vulgaris, thereby causing algal death. Coumoxystrobin can be used in studies related to rice blast disease.
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Filipin II
0 Images製品番号: HY-130772CAS 番号: 38620-77-8Filipin II is an antibiotic, which exhibits antifungal efficacy. Filipin II interacts with membrane sterols, leads to changes in membrane structure, inhibits Candida utilis and Saccharomyces cerevisiae with the MIC of 0.03 mg/L and 0.2 μg/L.
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Demethylblasticidin S
0 Images製品番号: HY-N15350CAS 番号: 63257-29-4Demethylblasticidin S is an antifungal antibiotic that can be synthesized by Streptomyces griseochromogenes.
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3-Nitrocoumarin (Standard)
0 Images製品番号: HY-111919RCAS 番号: 28448-04-63-Nitrocoumarin (Standard) is the analytical standard of 3-Nitrocoumarin (HY-111919). This product is intended for research and analytical applications. 3-Nitrocoumarin is an inhibitor for phospholipase C that blocks the generation of inositol triphosphate (IP3), thereby affecting the calcium signaling pathway.
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Dioctatin A hydrochloride
0 Images製品番号: HY-134666ADioctatin A hydrochloride is a metabolite of Streptomyces and an inhibitor of human dipeptidyl aminopeptidase II. Dioctatin A hydrochloride can inhibit aflatoxin production by Aspergillus parasiticus with an IC50 of 4.0 μM. Dioctatin A hydrochloride can reduce the mRNA levels of aflatoxin biosynthetic genes and the regulatory gene aflR, inhibit conidiation and decrease the mRNA level of the brlA gene, and also promote kojic acid production. In addition, Dioctatin A hydrochloride can inhibit sterigmatocystin production. Dioctatin A hydrochloride has pleiotropic regulatory effects on the production and differentiation of fungal secondary metabolites.
