Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2737)
Related Products (2737)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Ciclopirox-d11
0 ImagesCat. No.: HY-B0450SSynonyms: HOE296b-d11Ciclopirox-d11 is the deuterium labeled Ciclopirox. Ciclopirox (HOE296b) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic.
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Strevertene A
0 ImagesCat. No.: HY-N16445CAS No.: 235090-14-9Synonyms: (-)-Strevertene AStrevertene A ((-)-Strevertene A) (Compound 1), a pentaene macrolide, is a microbial secondary metabolite. Strevertene A is an antibiotic and has a potent antifungal activity. Strevertene A significantly inhibits the mycelial growth of phytopathogenic fungi (such as Alternaria mali, Aspergillus oryzae and Cylindrocarpon destructans) with IC50s of 4-16 μg/mL. Strevertenes A can strongly prevent Fusarium wilt development on tomato plants.
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Antibacterial agent 215
0 ImagesCat. No.: HY-162521Antibacterial agent 215 (Compound 3b) is an inhibitor for carbonic anhydrase (CA), with Ki of 17.61, 5.14 and 43.74 nM, for hCA I, hCA II and AChE, respectively. Antibacterial agent 215 exhibits anti-tuberculosis, with MIC of 62.5 µg/ml against M. tuberculosis. Antibacterial agent 215 exhibits antifungal activities against Candida spp. strains ATCC 14053, ATCC 1369, and ATCC 15126, with MICs of 125 µg/ml.
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Funiculosin
0 ImagesCat. No.: HY-N12201CAS No.: 11055-06-4Funiculosin is a neutral lipophilic antibiotic that inhibits DNA and RNA viruses. Funiculosin also has antifungal activity. Funiculosin inhibits infections caused by pathogenic fungi in primary chicken embryo fibroblasts.
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Antifungal agent 20
0 ImagesCat. No.: HY-132968CAS No.: 2460281-94-9Antifungal agent 20 exhibits remarkable antifungal activity against Colletotrichum gloeosprioides, Rhizoctonia solani, Phytophthora nicotianae var. nicotianae, Diplodia pinea, Colletotrichum acutatum, and Fusarium oxysporum f. sp. niveum.
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Melithiazole B
0 ImagesCat. No.: HY-N14249CAS No.: 170894-31-2Melithiazol B is an antibiotic. Melithiazole B is a β-methoxyacrylate (MOA) inhibitor with strong anti-agent activity. Antifungal and cytotoxic agent.
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13-Hydroxy-9-octadecenoic acid
0 ImagesCat. No.: HY-N13284CAS No.: 324575-43-113-Hydroxy-9-octadecenoic acid is a hydroxy unsaturated fatty acid (HUFA) that has anti-fungal activity.
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5,7-Dihydroxychromone (Standard)
0 ImagesCat. No.: HY-N1970RCAS No.: 31721-94-55,7-Dihydroxychromone (Standard) is the analytical standard of 5,7-Dihydroxychromone (HY-N1970). This product is intended for research and analytical applications. 5,7-Dihydroxychromone is a flavonoid compound with antioxidant properties. 5,7-Dihydroxychromone induces Nrf2 nuclear translocation, increases Nrf2/ARE binding activity, and up-regulates Nrf2-dependent antioxidant genes HO-1, NQO1, GCLc. 5,7-Dihydroxychromone attenuates excessive ROS generation, inhibits activated caspase-3, caspase-9, cleaved PARP expression, and prevents neuronal apoptosis and cell death. 5,7-Dihydroxychromone increases LXRα and PPARγ mRNA expression, induces preadipocyte differentiation, and regulates blood glucose levels. 5,7-Dihydroxychromone inhibits radial growth of soil pathogenic fungi, radicle elongation of select seedlings, and transiently inhibits Bradyrhizobium sp. growth in high mannitol medium. 5,7-Dihydroxychromone can be used for the research of Parkinson’s disease, type 2 diabetes mellitus and pathogenic fungal infection.
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AK-toxin Ⅰ
0 ImagesCat. No.: HY-N14936CAS No.: 85146-09-4AK-toxin I is a host-specific phytotoxic metabolite. AK-toxin I causes black spot disease of pear trees.
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Isoxanthohumol (Standard)
0 ImagesIsoxanthohumol (Standard) is the analytical standard of Isoxanthohumol (HY-N2584A). This product is intended for research and analytical applications. Isoxanthohumol is an orally active flavonoid compound. Isoxanthohumol has biological activities such as anti-tumor, anti-inflammatory, antioxidant, antiviral, antifungal, and inhibition of adipogenesis. Isoxanthohumol can induce apoptosis, autophagy, and migration of tumor cells. Isoxanthohumol is active against viruses such as HSV, BVDV, CMV, and Rhino. Isoxanthohumol can be used for the research of tumors, metabolic, and inflammatory diseases.
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Neothramycin A
0 ImagesCat. No.: HY-129331CAS No.: 59593-16-7Neothramycin A is an antibiotic, which can be isolated from Streptomyces. Neothramycin A exhibits board spectrum antimicrobial activity, inhibits Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli W677, and Saccharomyces cerevisia with MIC of 25-50 μg/mL. Neothramycin A exhibits antitumor efficacy against leukemia in mouse models.
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Antibiotic AB023a
0 ImagesCat. No.: HY-137084CAS No.: 141443-39-2Antibiotic AB023a is part of macrocyclic pentaene antibiotic complex, forming the main components with Antibiotic AB023b (HY-137085). Antibiotic AB023a exhibits antifungal activity against Candida albicans, and plant pathogenic fungi, Botrytis cinerea (MIC= 5 μg/mL), Fusarium moniliforme and Pythium ultimum.
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Phoslactomycin A
0 ImagesCat. No.: HY-N12681CAS No.: 159991-67-0Phoslactomycin A has weak effect against Gram-positive bacteria, but has strong effect against fungi.
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Epelmycin C
0 ImagesCat. No.: HY-N14157CAS No.: 107807-23-8Epelmycin C has anti-Gram positive, negative bacteria and candida albicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin.
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Naphthoquinomycin A
0 ImagesCat. No.: HY-N14829CAS No.: 101190-62-9Naphthoquinomycin A is an Ansa antibiotic with anti-Gram-positive bacteria and fungi activity, and can inhibit the synthesis of E. coli fatty acids.
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AFK-108
0 ImagesCat. No.: HY-117869CAS No.: 135330-85-7AFK-108 is a potent antifungal agent. AFK-108 inhibits the activity of 14 alpha-demethylase.
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Farinomalein A
0 ImagesCat. No.: HY-167834CAS No.: 1175521-35-3Farinomalein A is a maleimide that can be isolated from Paecilomyces farinosus. Farinomalein A has potent inhibition of Phytophtora sojae.
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Benalaxyl
0 ImagesBenalaxyl is a systemic fungicide. Benalaxyl exhibits inhibitory activity against downy mildew (Peronospora tabacina) in tobacco plants. Benalaxyl can be used in studies related to downy mildew.
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Pyrazophos
0 ImagesSynonyms: CuramilPyrazophos (Curamil) is a slightly systemic fungicide against the powdery mildew on crops and cereals. Pyrazophos is widely used in Greece to control diseases caused by Erysiphe spp., Sphaerotheca spp., Leveillula spp. and Oidium spp..
