2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-182586
    Decyl gallate
    Decyl gallate is an antifungal (fungal) agent. Decyl gallate downregulates the expression of the pro-apoptotic (apoptosis) protein Bak, upregulates the expression of the anti-apoptotic protein Bcl-2, and inhibits DNA damage. Decyl gallate disrupts ALG12-mediated N-glycosylation, overactivates the UPR pathway, and simultaneously reduces fungal cell wall enzyme activity, chitin levels, mitochondrial activity, budding ability, cell viability, and host cell adhesion capacity. Decyl gallate reduces inflammatory responses induced by fungal infection and disrupts fungal membrane structure. Decyl gallate can be used in studies related to paracoccidioidomycosis and invasive fungal infections.
    Decyl gallate
  • HY-B0348R
    Liranaftate (Standard)
    		Inhibitor
    Liranaftate (Standard) is the analytical standard of Liranaftate. This product is intended for research and analytical applications. Liranaftate (Piritetrate) is a squalene epoxidase inhibitor with anti-fungicidal activities. Liranaftate can be used for the research of dermatophytes. Liranaftate also suppresses fungal element-promoted production of IL-8 and experimental inflammation.
    Liranaftate (Standard)
  • HY-W019803R
    Diclobutrazol (Standard)
    		Inhibitor
    Diclobutrazol (Standard) is the analytical standard of Diclobutrazol. This product is intended for research and analytical applications. Diclobutrazol, a systemic fungicide, is highly active against rusts, powdery mildews, and other fungal phytopathogens. Diclobutrazol can be used as a pesticide to control of various crop diseases.
    Diclobutrazol (Standard)
  • HY-N14509
    Queenslandon
    		Inhibitor
    Queenslandon has moderate anti-streptomyces, penicillium, Penicillium, Aspergillus fumigatus, aspergillus flavus and other fungal activities. And it has no effect on bacteria.
    Queenslandon
  • HY-106923
    BMS-181184
    		Inhibitor
    BMS-181184 is a new Pradimicin derivative and fungicide. BMS-181184 exhibits fungicidal activity against yeasts, dermatophytes, and most Aspergillus fumigatus strains. BMS-181184 is active against Sporothrix schenckii, dematiaceous fungi, and some members of the non-Aspergillus hyaline hyphomycetes.
    BMS-181184
  • HY-116541R
    Acibenzolar-S-methyl (Standard)
    		Inhibitor
    Acibenzolar-S-methyl (Standard) is the analytical standard of Acibenzolar-S-methyl. This product is intended for research and analytical applications. Acibenzolar-S-methyl (ASM) is a plant resistance inducer that mimics pathogen-host interactions and leads to systemic acquired resistance in plants. Acibenzolar-S-methyl helps reduce the use of pesticides and can be used in research to prevent plant diseases.
    Acibenzolar-S-methyl (Standard)
  • HY-B1863R
    Iprobenfos (Standard)
    		Inhibitor
    Iprobenfos (Standard) is the analytical standard of Iprobenfos (HY-B1863). This product is intended for research and analytical applications. Iprobenfos is an organophosphorus fungicide and is widely used to control the rice blast fungus. Iprobenfos can phosphorylate the -OH group on the serine residue in the active (esteratic) site of ChEs and so inhibit both AChE and BChE activity.
    Iprobenfos (Standard)
  • HY-B0359R
    Fenticonazole Nitrate (Standard)
    		Inhibitor
    Fenticonazole (Nitrate) (Standard) is the analytical standard of Fenticonazole (Nitrate). This product is intended for research and analytical applications. Fenticonazole Nitrate is an antifungal imidazole ring derivative. Fenticonazole Nitrate operates via hindering ergosterol integration, and sequentially destructing the cytoplasmatic outer membrane. Fenticonazole Nitrate is effective against Gram-positive bacteria, mycoses, and vaginal candidiasis.
    Fenticonazole Nitrate (Standard)
  • HY-N14984
    Galbonolides A
    		Inhibitor
    Galbonolides A exhibits biological activity against a broad spectrum of fungi.
    Galbonolides A
  • HY-128429S
    trans-2-Hexenal-d2-1
    		Inhibitor
    trans-2-Hexenal-d2-1 is the deuterium labeled trans-2-Hexenal (HY-128429). trans-2-Hexenal ((E)-2-Hexenal) is a volatile compound widely present in fresh plants, vegetables, and fruits, with a unique leafy aroma. trans-2-Hexenal has antifungal activity and can also inhibit the germination of soybean seeds and the growth of seedlings. In addition, trans-2-Hexenal can be used to determine low-molecular-weight carbonyl compounds that are reactive with biological nucleophiles in biological samples.
    trans-2-Hexenal-d<sub>2</sub>-1
  • HY-N14112
    Cuevaene B
    		Inhibitor
    Cuevaene B can be isolated from the strain of gdmAI-disrupted Streptomyces sp. LZ35 and. Cuevaene B displays moderate activity against Gram-positive bacteria (e.g., Bacillus subtilis strain ATCC 11060) and modest activity against fungi (e.g., Fusarium verticillioides strain S68 and Rhizoctonia solani strain GXE4).
    Cuevaene B
  • HY-126114R
    Lupeol acetate (Standard)
    		Inhibitor
    Lupeol acetate (Standard) is the analytical standard of Lupeol acetate. This product is intended for research and analytical applications. Lupeol acetate is a derivative of Lupeol. Lupeol acetate is an anti-inflammatory, antibacterial, anti-trypanosomic and anticancer agent with oral activity. Lupeol acetate significantly improves the symptoms of rheumatoid arthritis by down-regulating the expression of inflammatory cytokines and osteoclast production. Lupeol acetate inhibits spermatogenesis in male rats and eventually led to infertility.
    Lupeol acetate (Standard)
  • HY-N6951R
    Guaiazulene (Standard)
    		Inhibitor
    Guaiazulene (Standard) is the analytical standard of Guaiazulene (HY-N6951). This product is intended for research and analytical applications. Guaiazulene is a bicyclic sesquiterpene that can cross the blood-brain barrier. Guaiazulene exhibits various biological activities such as anti-inflammatory, antioxidant, hepatoprotective, antibacterial, and anti-tumor properties. Guaiazulene is also commonly used as a colorant in cosmetics. Guaiazulene shows in vitro cytotoxicity to rat neuronal cells and N2a neuroblastoma cells at high concentrations.
    Guaiazulene (Standard)
  • HY-N8431
    5-Geranoxy-7-methoxycoumarin
    		Inhibitor 98.24%
    5-Geranoxy-7-methoxycoumarin is a coumarin with anti-cancer, antifungal, and ?antibacterial?activities. 5-Geranoxy-7-methoxycoumarin induces cell apoptosis.
    5-Geranoxy-7-methoxycoumarin
  • HY-N14853
    Ossamycin
    		Inhibitor
    Ossamycin is a macrolide antibiotic. Ossamycin has anti-fungal effect, and it has weaker anti-Gram-positive bacterial effect. Ossamycin inhibits L cells, Epstein-Barr ascites cancer cells, KB cells, sarcoma-180 cells, L-1210 cells, HeLa cells in cell culture with IC50s (μg/mL) of 0.007, 0.008, 0.005, 0.008, 0.003, 0.005, respectively.
    Ossamycin
  • HY-N14472
    Fusacandin B
    		Inhibitor
    Fusacandin B inhibits (1,3)-β-glucan synthetase and has antifungal properties.
    Fusacandin B
  • HY-77995R
    2-Methoxybenzaldehyde (Standard)
    		Inhibitor
    2-Methoxybenzaldehyde (Standard) is the analytical standard of 2-Methoxybenzaldehyde. This product is intended for research and analytical applications. 2-Methoxybenzaldehyde (o-Anisaldehyde) is a bacterial/fungal inhibitor with a BA50 value of 0.19 for Salmonella. 2-Methoxybenzaldehyde can be used for the study of bacterial and fungal infectious diseases.
    2-Methoxybenzaldehyde (Standard)
  • HY-N14123
    Cladosporide C
    		Inhibitor
    Cladosporide C is found in the strain of Cladosporium sp. IFM 49190. Cladosporide C has no antifungal activity.
    Cladosporide C
  • HY-N3089
    Phaseollidin
    		Inhibitor
    Phaseollidin is an antifungal agent that can be isolated from Phaseolus vulgaris L..
    Phaseollidin
  • HY-N14554
    Dihydroniphimycin
    		Inhibitor
    Dihydroniphimycin has anti-fungal, yeast and Gram-positive bacteria action.
    Dihydroniphimycin
Cat. No. Product Name / Synonyms Application Reactivity