Free Fatty Acid Receptor Agonist
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AM-3189
0 ImagesCat. No.: HY-111141CAS No.: 916219-50-6AM-3189 is an orally active and selective GPR40 agonist with EC50 values in buffer solution and in 100% human serum of 33 nM and 10 μM respectively. AM-3189 shows no significant activity on GPR41 and GPR43, and no agonistic activity on PPAR-α, -δ, and -γ. AM-3189 enhances glucose-stimulated insulin secretion by activating GPR40 on pancreatic β cells. AM-3189 has extremely low penetration into the central nervous system and significantly reduces blood glucose levels in two humanized GPR40 mouse models. AM-3189 can be used for the study of type 2 diabetes.
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Icosabutate (Standard)
0 ImagesCat. No.: HY-121212RCAS No.: 1253909-57-7Desmethyl Sibutramine (hydrochloride) (Standard) is the analytical standard of Desmethyl Sibutramine (hydrochloride). This product is intended for research and analytical applications. Icosabutate is an orally active engineered fatty acid and a dual FFAR1/FFAR4 (GPR40/GPR120) agonist with EC50 values of 10 μM and 15.5 μM, respectively. Icosabutate acts as a partial agonist of PPAR-α, with an EC50 of 208 nM. Icosabutate inhibits the arachidonic acid cascade and exhibits antioxidant and anti-apoptotic activities. Icosabutate can be used in the research of nonalcoholic steatohepatitis, metabolic dysfunction-associated steatohepatitis, and atherosclerosis.
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TUG-891 (Standard)
0 ImagesTUG-891 (Standard) is the analytical standard of TUG-891. This product is intended for research and analytical applications. TUG-891 is a potent and selective agonist for the long chain free fatty acid (LCFA) receptor 4 (FFA4/GPR120).
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Vincamine (Standard)
0 ImagesVincamine (Standard) is the analytical standard of Vincamine. This product is intended for research and analytical applications. Vincamine is a monoterpenoid indole alkaloid extracted from the Madagascar periwinkle. Vincamine is a peripheral vasodilator and exerts a selective vasoregulator action on the brain microcapilar circulation. Vincamine is a GPR40 agonist and acts as a β-cell protector by ameliorating β-cell dysfunction and promoting glucose-stimulated insulin secretion (GSIS). Vincamine improves glucose homeostasis in vivo, and has the potential for the type 2 diabetes mellitus (T2DM) research.
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GPR120 Agonist 2 (Standard)
0 ImagesCat. No.: HY-111353RCAS No.: 1234844-11-1GPR120 Agonist 2 (Standard) is the analytical standard of GPR120 Agonist 2 (HY-111353). This product is intended for research and analytical applications. GPR120 Agonist 2 (example 206) is a GPR120 agonist that can be uesd for the study of type II diabetes and diseases associated with poor glycemic control.
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LY2922083
0 ImagesCat. No.: HY-117978CAS No.: 1309435-78-6LY2922083 and related compounds LY2881835 and LY2922470 are spiperidine and tetrahydroquinolinic acid derivatives that are potent GPR40 agonists. LY2922083 activates GPR40 in response to elevated blood glucose and has the potential to be a glucose-lowering agent.
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GPR40 agonist 4 (Standard)
0 ImagesCat. No.: HY-103083RCAS No.: 2102196-57-4GPR40 agonist 4 (Standard) is the analytical standard of GPR40 agonist 4 (HY-103083). This product is intended for research and analytical applications. GPR40 agonist 4 is a potent free fatty acid receptor 1 (FFA1/ GPR40) agonist with a pEC50 of 7.54.
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GPR40/FFAR1 modulator 1 (Standard)
0 ImagesCat. No.: HY-111763RCAS No.: 874755-26-7GPR40/FFAR1 modulator 1 (Standard) is the analytical standard of GPR40/FFAR1 modulator 1 (HY-111763). This product is intended for research and analytical applications. GPR40/FFAR1 modulator 1 is an agonist and an allosteric modulator for Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1).
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GPR120 Agonist 3 (Standard)
0 ImagesGPR120 Agonist 3 (Standard) is the analytical standard of GPR120 Agonist 3 (HY-101492). This product is intended for research and analytical applications. GPR120 Agonist 3 is a selective Gpr120 agonist with a logEC50 of 7.62.
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Fezagepras sodium (Standard)
0 ImagesSynonyms: Setogepram sodium (Standard); PBI-4050 sodium (Standard)Fezagepras (sodium) (Standard) is the analytical standard of Fezagepras (sodium). This product is intended for research and analytical applications. Fezagepras (Setogepram) sodium acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84. Fezagepras sodium decreases renal, liver and pancreatic fibrosis. Fezagepras sodium exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions.
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Fezagepras (Standard)
0 ImagesCat. No.: HY-100775ARCAS No.: 1002101-19-0Synonyms: Setogepram (Standard); PBI-4050 (Standard)Fezagepras (Standard) is the analytical standard of Fezagepras. This product is intended for research and analytical applications. Fezagepras (Setogepram) acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84. Fezagepras decreases renal, liver and pancreatic fibrosis. Fezagepras exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions.
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GPR40 Agonist 2
0 ImagesCat. No.: HY-U00395CAS No.: 1147729-48-3GPR40 Agonist 2 is a GPR40 agonist that can be used in the research of diabetes, extracted from patent WO2009054479A1.
