1617-90-9
Chemical Structure
Vincamine
- CAS No.: 1617-90-9
- Formula:C21H26N2O3
- Molecular Weight:354.44
IUPAC Name: methyl (41S,12S,13aS)-13a-ethyl-12-hydroxy-2,3,41,5,6,12,13,13a-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate
InChIKey: RXPRRQLKFXBCSJ-GIVPXCGWSA-N
SMILES: O=C(OC)[C@@]1(O)C[C@@]2(CC)[C@@]3([H])C(N1C4=CC=CC=C54)=C5CCN3CCC2
Biological Activity: Vincamine is a monoterpenoid indole alkaloid extracted from the Madagascar periwinkle. Vincamine is a peripheral vasodilator and exerts a selective vasoregulator action on the brain microcapilar circulation[1]. Vincamine is a GPR40 agonist and acts as a β-cell protector by ameliorating β-cell dysfunction and promoting glucose-stimulated insulin secretion (GSIS). Vincamine improves glucose homeostasis in vivo, and has the potential for the type 2 diabetes mellitus (T2DM) research[2].
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Vincamine | 99.34% | Vincamine is a monoterpenoid indole alkaloid extracted from the Madagascar periwinkle. Vincamine is a peripheral vasodilator and exerts a selective vasoregulator action on the brain microcapilar circulation. Vincamine is a GPR40 agonist and acts as a β-cell protector by ameliorating β-cell dysfunction and promoting glucose-stimulated insulin secretion (GSIS). Vincamine improves glucose homeostasis in vivo, and has the potential for the type 2 diabetes mellitus (T2DM) research. | ||||||||||||||||||||
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Vincamine (Standard) | ≥98% | Vincamine (Standard) is the analytical standard of Vincamine. This product is intended for research and analytical applications. Vincamine is a monoterpenoid indole alkaloid extracted from the Madagascar periwinkle. Vincamine is a peripheral vasodilator and exerts a selective vasoregulator action on the brain microcapilar circulation. Vincamine is a GPR40 agonist and acts as a β-cell protector by ameliorating β-cell dysfunction and promoting glucose-stimulated insulin secretion (GSIS). Vincamine improves glucose homeostasis in vivo, and has the potential for the type 2 diabetes mellitus (T2DM) research. | ||||||||||||||||||||
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Similarity Score 0.76
HY-4614216,17-Dihydroapovincamine -
Similarity Score 0.71
HY-124925Vincanol -
Similarity Score 0.68
HY-B1180RVinburnine (Standard) -
Similarity Score 0.67
HY-135743Apovincamine -
Similarity Score 0.66
HY-133813AApovincaminic acid hydrochloride salt -
Similarity Score 0.66
HY-133813Apovincaminic acid -
Similarity Score 0.65
HY-13295Vinpocetine -
Similarity Score 0.63
HY-147502Vin-C01 -
Similarity Score 0.61
HY-13295SVinpocetine-d5 -
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References
- [1]. Te Du, et al. Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice. J Endocrinol. 2019 Feb 1;240(2):195-214. [Content Brief]
- [2]. Li Wu, et al. Vincamine prevents lipopolysaccharide induced inflammation and oxidative stress via thioredoxin reductase activation in human corneal epithelial cells. Am J Transl Res. 2018 Jul 15;10(7):2195-2204. eCollection [Content Brief]
