2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. MMP
  5. ADAM10 Isoform
  6. ADAM10 Agonist

ADAM10 Agonist

ADAM10 Agonist (1):

Cat. No. Product Name Effect Purity
  • HY-P11540
    CCKBR agonist-1
    		Agonist 98.48%
    CCKBR agonist-1 (Compound 3r1) is a Gq-protein-preferring cholecystokinin B receptor (CCKBR) agonist with an EC50 of 35 pM. CCKBR agonist-1 significantly increases the survival rate of neurons, with an EC50 of 37 pM. CCKBR agonist-1 can improve the cognitive decline in mice by upregulating α-secretase (ADAM10) and calcium signaling molecule PLCB4, reduce the number of amyloid β (Aβ) plaques, and promote long-term potentiation (LTP). CCKBR agonist-1 can be used for the study of Alzheimer's disease.