NF-κB Ligand

9''-Methyl salvianolate B (MSB) is a blood-brain barrier-permeable inhibitor with high affinity for g5Rp, with a K_d value of 117 nM against African swine fever virus (ASFV) g5Rp. 9''-Methyl salvianolate B also acts as a ZBP1 inhibitor. It exhibits strong binding affinity to key proteins in the PPARγ/NF-κB pathway. 9''-Methyl salvianolate B blocks the interaction between ASFV g5Rp and host proteins eIF5A or RPS15. It restores hypusination modification of eIF5A, promotes autophagy (Autophagy), and inhibits ASFV replication. 9''-Methyl salvianolate B effectively disrupts ZBP1-mediated PANoptosome assembly. It effectively alleviates myocardial ischemia/reperfusion injury. 9''-Methyl salvianolate B can be used in studies related to African swine fever.

14-3-3σ/p65 binder-1 is a binding agent targeting 14-3-3/p65. 14-3-3σ/p65 binder-1 binds within the 14-3-3/p65 composite pocket, forms hydrogen bonds with p65, and does not significantly increase the formation of the ternary complex. 14-3-3σ/p65 binder-1 can be used for inflammation-related research.

NIK ligand 1 (compound 2) is a NF-κB inducing kinase (NIK) ligand.