Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
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Nucleoside Antimetabolite/Analog Related Products (2437)
Related Products (2437)
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(±)-Lobucavir
0 ImagesCat. No.: HY-105098BCAS No.: 126062-18-8Synonyms: (±)-BMS-180194; SQ 33054(±)-Lobucavir ((±)-BMS-180194) is a nucleoside analog with carcinogenic activity. In mice, chronic administration of (±)-Lobucavir resulted in tumor formation with a tumor spectrum similar to that observed after chronic administration of zidovudine or ganciclovir.
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6-Chloro-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purine
0 ImagesCat. No.: HY-W020420CAS No.: 135473-15-36-Chloro-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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DL-Alanosine-15N2
0 ImagesCat. No.: HY-W698934CAS No.: 1219187-51-5DL-Alanosine-15N2 is the 15N-labeled DL-Alanosine (HY-13548). DL-Alanosine is an amino acid analogue with antitumor activities.
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3’,5’-Di-O-acetyl-2’-deoxy-5,N3-dimethyluridine
0 ImagesCat. No.: HY-154562CAS No.: 144874-49-73’,5’-Di-O-acetyl-2’-deoxy-5,N3-dimethyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5-Amino-2'-deoxyuridine monohydrochloride
0 ImagesCat. No.: HY-154026CAS No.: 73446-40-95-Amino-2'-deoxyuridine (monohydrochloride) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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Cytidine-d2-1
0 ImagesCat. No.: HY-B0158S3CAS No.: 478511-21-6Synonyms: Cytosine β-D-riboside-d2-1; Cytosine-1-β-D-ribofuranoside-d2-1
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5'-O-DMT-ibu-dC
0 ImagesCat. No.: HY-138605CAS No.: 100898-62-25'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides.
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5-(3-Azidopropyl)cytidine
0 ImagesCat. No.: HY-1527875-(3-Azidopropyl)cytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities. 5-(3-Azidopropyl)cytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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5’-O-DMT-2’-deoxy-2’-fluoro-β-D-arabinouridine
0 ImagesCat. No.: HY-154410CAS No.: 144822-63-9
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Cytarabine-13C,15N2
0 ImagesCat. No.: HY-13605S1Synonyms: Cytosine β-D-arabinofuranoside-13C,15N2; Cytosine arabinoside-13C,15N2; Ara-C-13C,15N2Cytarabine-13C,15N2 (Cytosine β-D-arabinofuranoside-13C,15N2) is the 13C- and 15N-labeled Cytarabine (HY-13605). Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.
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6-Methoxypurine-9-beta-D-(3-methoxy riboside)
0 ImagesCat. No.: HY-1526476-Methoxypurine-9-beta-D-(3-methoxy riboside) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3′,5′-Di-O-acetyl-2′-deoxy-2′-fluorouridine
0 ImagesCat. No.: HY-154813CAS No.: 10212-13-2
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2-Amino-6-O-methyl-2’-O-methyl purine riboside
0 ImagesCat. No.: HY-1526602-Amino-6-O-methyl-2’-O-methyl purine riboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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L-5-Methyluridine
0 ImagesCat. No.: HY-148168CAS No.: 26879-47-0L-5-Methyluridine is the L-configuration of 5-Methyluridine (HY-W009444). 5-Methyluridine is an endogenous methylated nucleoside.
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2’-Azido-2’-deoxy-5-methyl cytidine
0 ImagesCat. No.: HY-152642CAS No.: 2095417-75-52’-Azido-2’-deoxy-5-methyl cytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 2’-Azido-2’-deoxy-5-methyl cytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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3’-Deoxy-3’-α-C-methyl-5-fluorouridine
0 ImagesCat. No.: HY-152412CAS No.: 37731-67-23’-Deoxy-3’-α-C-methyl-5-fluorouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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Fosfluridine tidoxil
0 ImagesCat. No.: HY-19514CAS No.: 174638-15-4Fosfluridine Tidoxil is comprised of a specific carrier molecule, coupled through a phosphate group to 5-Fluorouridine (5-FUrd), a metabolite of 5- Fluorouracil (5-FU). Fosfluridine Tidoxil is a oral active anticancer agent.
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Methyl 2-deoxy-3,5-di-O-benzoyl-2-fluoro-4-thio-D-arabinopentofuranoside
0 ImagesCat. No.: HY-154321CAS No.: 221552-92-7Methyl 2-deoxy-3,5-di-O-benzoyl-2-fluoro-4-thio-D-arabinopentofuranoside is a ribofuranose nucleoside analogue.
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2’-β-C-Methyl-5-methyluridine
0 ImagesCat. No.: HY-152629CAS No.: 119410-84-32’-β-C-Methyl-5-methyluridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2’-Deoxy-N2,N2-dimethylguanosine
0 ImagesCat. No.: HY-154407CAS No.: 88127-22-42’-Deoxy-N2,N2-dimethylguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
