Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
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Nucleoside Antimetabolite/Analog Related Products (2437)
Related Products (2437)
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2’,3’-Bis-(O-t-butyldimethylsilyl)uridine
0 ImagesCat. No.: HY-154420CAS No.: 69504-12-72’,3’-Bis-(O-t-butyldimethylsilyl)uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3-O-Benzoyl-1,2: 5,6-bis(di-O-isopropylidene)-alpha-D-galactofuranose
0 ImagesCat. No.: HY-154720CAS No.: 29474-73-53-O-Benzoyl-1,2: 5,6-bis(di-O-isopropylidene)-alpha-D-galactofuranose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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Rp-ATPαS tetrasodium
0 ImagesCat. No.: HY-137626CCAS No.: 661465-43-6Rp-ATPαS is a monomeric raw material that can be used for nucleic acid synthesis.
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8-Azido-2′-deoxyadenosine
0 ImagesCat. No.: HY-154025CAS No.: 131265-35-58-Azido-2′-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2-Hydroxy-2’-deoxy-2’-fluoro-beta-D-arabino adenosine
0 ImagesCat. No.: HY-152661CAS No.: 899827-82-82-Hydroxy-2’-de oxy-2’-fluoro-beta-D-arabino adenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2-Hydroxyhepta-2,4-dienedioate
0 ImagesCat. No.: HY-180725CAS No.: 53795-97-42-Hydroxyhepta-2,4-dienedioate is a nucleoside metabolite.
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2',3',5'-Tri-O-benzoyl-2'-beta-C-methyl-6-azauridine
0 ImagesCat. No.: HY-154117CAS No.: 622379-83-32',3',5'-Tri-O-benzoyl-2'-beta-C-methyl-6-azauridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3’-O-Methyl-4-deoxy uridine
0 ImagesCat. No.: HY-152721CAS No.: 2095417-12-03’-O-Methyl-4-deoxy uridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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Formyl-5-hydroxykynurenamine
0 ImagesCat. No.: HY-180770CAS No.: 958733-17-0Formyl-5-hydroxykynurenamine is produced from serotonin catalyzed by the enzyme IDO1.
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1-(3-β-Azido-2,3-dideoxy-5-O-trityl-D-threopenta-furanosyl)thymine
0 ImagesCat. No.: HY-154686CAS No.: 66503-47-71-(3-β-Azido-2,3-dideoxy-5-O-trityl-D-threopenta-furanosyl)thymine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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9,10-Dihydroxy-12,13-epoxyoctadecanoate
0 ImagesCat. No.: HY-W754698CAS No.: 127105-40-29,10-Dihydroxy-12,13-epoxyoctadecanoate is a metabolite that is involved in the linoleic acid metabolism pathway.
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3’-β-C-Methyl-2-thiouridine
0 ImagesCat. No.: HY-1524973’-β-C-Methyl-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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Ap5dT
0 ImagesCat. No.: HY-177023CAS No.: 103137-88-8Ap5dT is a cytosolic thymidine kinase and mitochondrial enzyme inhibitor with Kis of 0.12 μM and 0.50 μM, respectively. Ap5dT can be used for the study of acute myelocytic leukemia.
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7,8-Dihydro-8-oxo-7-propargyl-3’-deoxy guanosine
0 ImagesCat. No.: HY-154284CAS No.: 2389988-54-77,8-Dihydro-8-oxo-7-propargyl-3’-deoxy guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 7,8-Dihydro-8-oxo-7-propargyl-3’-deoxy guanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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6-Methoxy purine-9-beta-D-(3’-deoxy-3’-fluoro)riboside
0 ImagesCat. No.: HY-152695CAS No.: 2072145-35-66-Methoxy purine-9-beta-D-(3’-deoxy-3’-fluoro)riboside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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N6-Isopentenyl-2’-C-methyladenosine
0 ImagesCat. No.: HY-152416CAS No.: 2305416-13-9N6-Isopentenyl-2’-C-methyladenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
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OGT-719
0 ImagesCat. No.: HY-19272CAS No.: 185843-61-2OGT-719 is a potent, orally active nucleoside analogue that targets the asialoglycoprotein receptor (ASGP-R). OGT-719 inhibits growth of metastatic colorectal tumors in the liver of nude mice. OGT-719 can be used for primary hepatocellular carcinoma and colorectal liver metastases research.
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N1-Methyl-2’-O-(2-methoxyethyl) guanosine
0 ImagesCat. No.: HY-152567N1-Methyl-2’-O-(2-methoxyethyl) guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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4’-Azido-3’-O-benzoyl-5’-O-(m-chlorobenzoyl)-2’-deoxy-2’-fluoro-beta-D-arabinouridine
0 ImagesCat. No.: HY-154678CAS No.: 1333126-30-94’-Azido-3’-O-benzoyl-5’-O-(m-chlorobenzoyl)-2’-deoxy-2’-fluoro-beta-D-arabinouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 4’-Azido-3’-O-benzoyl-5’-O-(m-chlorobenzoyl)-2’-deoxy-2’-fluoro-beta-D-arabinouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
