Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
All Product Categories
-
Nucleoside Antimetabolite/Analog Related Products (2437)
Related Products (2437)
-
3'-O-DMTr-thymidine 5'-CE phosphoramidite
0 ImagesCat. No.: HY-W010681ACAS No.: 134031-86-03’-O-DMTr-thymidine 5’-CE phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
3-Methyl-5-β-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione
0 ImagesCat. No.: HY-152853CAS No.: 81691-06-73-Methyl-5-β-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
5-Methoxy-4’-thiouridine
0 ImagesCat. No.: HY-1528215-Methoxy-4’-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
2’-Deoxy-2’-fluoro-N1-methyladensoine
0 ImagesCat. No.: HY-1525042’-Deoxy-2’-fluoro-N1-methyladensoine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
Alpha-5-Methyluridine
0 ImagesAlpha-5-Methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
4’,5’-Didehydro-2’-O-(2-methoxyethyl)uridine
0 ImagesCat. No.: HY-154382CAS No.: 2095417-78-84’,5’-Didehydro-2’-O-(2-methoxyethyl)uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
3’-Deoxy-N6-methyladenosine
0 Images3’-Deoxy-N6-methyladenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
3’-Deoxy-3’-fluoro-beta-D-xylo-inosine
0 ImagesCat. No.: HY-152457CAS No.: 171667-46-23’-Deoxy-3’-fluoro-beta-D-xylo-inosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
S-(Indolylmethylthiohydroximoyl)-L-cysteine
0 ImagesCat. No.: HY-180751CAS No.: 1186649-18-2S-(Indolylmethylthiohydroximoyl)-L-cysteine is a secondary sulfur-containing metabolite found in glucosinolates.
-
GTI 2040 sodium
0 ImagesCat. No.: HY-153834AGTI-2040 sodium, a 20-mer phosphorothioate oligonucleotide, was designed to hybridize to the mRNA sequence of human ribonucleotide reductase R2. GTI-2040 sodium has been shown to inhibit human cancer cell proliferation by downregulation of R2 expression in vitro and to significantly inhibit tumor growth in xenograft models of human cancer in mice.
-
3’-Azido-N6-benzoyl-3’-deoxyadenosine
0 ImagesCat. No.: HY-154579CAS No.: 103597-10-03’-Azido-N6-benzoyl-3’-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-Azido-N6-benzoyl-3’-deoxyadenosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
-
3’-Deoxy-3-deazauridine
0 ImagesCat. No.: HY-152628CAS No.: 2095417-74-43’-Deoxy-3-deazauridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
E07 aptamer
0 ImagesCat. No.: HY-155983E07 aptamer is an aptamer that targets human EGFR. E07 aptamer can compete with EGF for binding, binds to a novel epitope on EGFR. E07 aptamer binds to cells expressing EGFR, blocks receptor autophosphorylation, and prevents proliferation of tumor cells in three-dimensional matrices. E07 aptamer can be used for tomor disease research.
-
2'-Deoxycytidine hydrochloride (Standard)
0 ImagesSynonyms: 2'-Deoxycytidine monohydrochloride (Standard); Deoxycytidine hydrochloride (Standard); NSC 83251 (Standard)2'-Deoxycytidine (hydrochloride) (Standard) is an analytical standard for 2'-Deoxycytidine (hydrochloride). This product is intended for research and analytical applications. 2'-Deoxycytidine hydrochloride is composed of the purine nucleoside guanine linked by its N9 nitrogen to the C1 carbon of deoxyribose.
-
2'-Fluoro-2'-deoxy-ara-U-3'-phosphoramidite
0 ImagesCat. No.: HY-48973CAS No.: 1190089-70-3
-
N6-Benzoyl-7’-OH-N-trityl morpholino adenine
0 ImagesCat. No.: HY-W357200CAS No.: 956139-16-5Synonyms: N-[9-(6-Hydroxymethyl-4-trityl-morpholin-2-yl)-9H-purin-6-yl]-benzamideN6-Benzoyl-7’-OH-N-trityl morpholino adenine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
5-Carboxymethyl-2-thiouridine
0 ImagesCat. No.: HY-152465CAS No.: 58479-77-95-Carboxymethyl-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
3’-beta-C-Methyl-5-methyluridine
0 ImagesCat. No.: HY-152391CAS No.: 934002-35-43’-beta-C-Methyl-5-methyluridine is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
