Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
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Nucleoside Antimetabolite/Analog Related Products (2437)
Related Products (2437)
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1-(2,3,5-Tri-O-benzoyl-2-C-methyl-β-D-ribofuranosyl)-2,4(1H,3H)-pyrimidinedione
0 ImagesCat. No.: HY-154652CAS No.: 23643-36-9
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5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-adenosine
![5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-adenosine](https://file.medchemexpress.com/product_pic/hy-w097775.gif "Click to View 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-adenosine Product Detail")
0 ImagesCat. No.: HY-W097775CAS No.: 81352-25-2Synonyms: 5'-O-(4,4'-DIMETHOXYTRITYL)ADENOSINE5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
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1,2-Dihydroxy-5-(methylthio)-1-penten-3-one
0 ImagesCat. No.: HY-29383CAS No.: 151169-51-61,2-Dihydroxy-5-(methylthio)-1-penten-3-one is a nucleoside metabolite.
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2’-Deoxy-2’-fluoroadenosine 5’-monophosphate triethylammonium
0 ImagesCat. No.: HY-1541562’-Deoxy-2’-fluoroadenosine 5’-monophosphate (triethylammonium) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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7-Cyano-7-deazaguanine
0 ImagesCat. No.: HY-W003845CAS No.: 69205-79-47-Cyano-7-deazaguanine is a key purine precursor molecule in the 7-deazaguanine pathway. 7-Cyano-7-deazaguanine acts as a substrate for transglycosylases to participate in base exchange reactions, replacing native guanine in nucleic acids to generate 7-deazaguanine-modified DNA or tRNA; it can be catalyzed by QueC/ToyM to form the 7-amido-7-deazaguanine (ADG) intermediate for further involvement in subsequent biosynthesis. 7-Cyano-7-deazaguanine is applicable to studies related to translation regulation.
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N1-(2-Methyl)propyl pseudouridine
0 ImagesCat. No.: HY-152336N1-(2-Methyl)propyl pseudouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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N6-Furfuryl-2’-C-methyladenosine
0 ImagesCat. No.: HY-152413CAS No.: 1042976-44-2N6-Furfuryl-2’-C-methyladenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2'-Deoxytubercidin 5'-triphosphate sodium
0 ImagesCat. No.: HY-131740ASynonyms: C7dATP sodium2'-Deoxytubercidin 5'-triphosphate sodium (C7dATP sodium) is a deoxyadenosine triphosphate (dATP) analog that serves as a substrate for DNA polymerases. 2'-Deoxytubercidin 5'-triphosphate sodium eliminates Hoogsteen base-pairing capacity and weakens base-stacking interactions; it is recognized and incorporated into nascent DNA strands by DNA polymerases such as Klenow and T7; it reduces DNA electrophoresis compression artifacts; it is effectively degraded by apyrase, thereby lowering the enzyme product inhibition effect caused by dATPaS. 2'-Deoxytubercidin 5'-triphosphate sodium reduces abnormal electrophoretic mobility caused by compression of G or A residues and is used to improve the quality of DNA sequencing data.
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Flurocitabine hydrochloride
0 ImagesCat. No.: HY-106218ACAS No.: 40505-45-1Synonyms: 5-Fluorocyclocytidine hydrochloride; 5'-Fluorocyclocytidine hydrochlorideFlurocitabine hydrochloride (5-Fluorocyclocytidine hydrochloride; 5'-Fluorocyclocytidine hydrochloride) is the hydrochloride form of Flurocitabine (HY-106218). Flurocitabine hydrochloride exhibits antitumor activity through hydrolysation in vivo into two active antitumor substances arabinosyl-tluorocytosine (ara-FC) and arabinosyl-fluorouracil (ara-FU).
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5-Methylcytidine 5′-triphosphate-d8 trisodium
0 ImagesCat. No.: HY-147338S2Synonyms: 5-Methyl-CTP-d8 trisodium5-Methylcytidine 5′-triphosphate-d8 trisodium (5-Methyl-CTP-d8 trisodium) is the deuterated-labeled 5-Methylcytidine 5′-triphosphate trisodium (HY-147338A). 5-Methylcytidine 5′-triphosphate trisodium is a modified cytidine triphosphate nucleotide. 5-Methylcytidine 5′-triphosphate trisodium serves as a modified nucleotide substrate for in vitro transcription, partially or completely replacing CTP. 5-Methylcytidine 5′-triphosphate trisodium enhances mRNA stability and translation efficiency, and reduces activation of the innate immune system. 5-Methylcytidine 5′-triphosphate trisodium is used in RNA synthesis-related research.
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3’-Deoxy-3’-fluoro-xylo-5-methylcytidine
0 ImagesCat. No.: HY-1524033’-Deoxy-3’-fluoro-xylo-5-methylcytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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4-Amino-1-(β-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine-5-carboxamide
![4-Amino-1-(β-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine-5-carboxamide](https://file.medchemexpress.com/product_pic/hy-152685.gif "Click to View 4-Amino-1-(β-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine-5-carboxamide Product Detail")
0 ImagesCat. No.: HY-1526854-Amino-1-(β-D-ribofurano syl)-7H-pyrrolo [2.3-d] pyrimidine-5-carboxamide is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5-Bromo-3’-deoxy-3’-fluorouridine
0 ImagesCat. No.: HY-152712CAS No.: 439579-22-35-Bromo-3’-deoxy-3’-fluorouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2'-C-Ethynyluridine
0 ImagesCat. No.: HY-W020361CAS No.: 188413-98-12'-C-Ethynyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 2'-C-Ethynyluridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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3’-O-Propargyladenosine
0 ImagesCat. No.: HY-152623CAS No.: 2305416-10-63’-O-Propargyladenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277). 3’-O-Propargyladenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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3’-Azido-3’-deoxy-beta-L-adenosine
0 ImagesCat. No.: HY-152601CAS No.: 216976-76-03’-Azido-3’-deoxy-beta-L-adenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-Azido-3’-deoxy-beta-L-adenosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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(2-Amino-1-hydroxyethyl)phosphonate
0 ImagesCat. No.: HY-W308027CAS No.: 41744-58-5Synonyms: 1-Hydroxy-2-aminoethylphosphonic acid(2-Amino-1-hydroxyethyl)phosphonate (1-Hydroxy-2-aminoethylphosphonic acid) is a nucleoside metabolite.
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7-(2-Deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
![7-(2-Deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine](https://file.medchemexpress.com/product_pic/hy-154003.gif "Click to View 7-(2-Deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine Product Detail")
0 ImagesCat. No.: HY-154003CAS No.: 93366-89-37-(2-Deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2’,3’,5’-Tri-O-acetyl-5-cyanouridine
0 ImagesCat. No.: HY-154273CAS No.: 1630743-99-52’,3’,5’-Tri-O-acetyl-5-cyanouridine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
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N6-iso-Propyl-2’-O-methyladenosine
0 ImagesCat. No.: HY-152653CAS No.: 2803878-84-2N6-iso-Propyl-2’-O-methyladenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
