OX₁ Receptor

OX₁ Receptor Related Products (20):

By Type:	Pan (8) Selective (10)
By Effects:	Agonists (8) Antagonists (12)

Cat. No.	Product Name	Effect	Purity

HY-106224A

Orexin A (human, rat, mouse) (TFA)	Agonist	98.33%
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes.

HY-10805

Almorexant	Antagonist	99.71%
Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with K_d values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively.

HY-10805A

Almorexant hydrochloride	Antagonist	99.98%
Almorexant (ACT 078573) hydrochloride is an orally active, potent and competitive dual orexin receptor antagonist, with K_d values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively.

HY-10900

TCS 1102	Antagonist	99.64%
TCS 1102 is a potent, dual orexin receptor antagonist, with Ki values of 0.2 nM and 3 nM for OX2 and OX1 receptors, respectively.

HY-19914

MK-1064	Antagonist	99.48%
MK-1064 is a selective and orally active OX₂R antagonist (K_i: 0.5 nM, IC₅₀: 18 nM).

HY-P3867

Hypocretin (70-98), human	Agonist
Hypocretin (70-98), human is a polypeptide that is capable of binding to an orexin receptor OX1R and promotes apoptosis.

HY-136181

YNT-185 dihydrochloride	Agonist	99.39%
YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC₅₀s of 0.028 and 2.75 μM for OX2R and OX1R, respectively.

HY-10898

SB-674042	Antagonist	99.84%
SB-674042 is a potent and selective non-peptide orexin OX₁ receptor antagonist (K_d=5.03 nM), exhibits 100-fold selectivity for OX₁ over OX₂ receptors with IC₅₀ values of 3.76 nM and 531 nM, respectively.

HY-106224

Orexin A (human, rat, mouse)	Agonist	99.15%
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes.

HY-101834

ACT-462206	Antagonist	99.60%
ACT-462206 is an orally active and potent dual Orexin 1/Orexin 2 receptor antagonist with IC₅₀s of 60 nM (Orexin 1) and 11 nM (Orexin 2), respectively.

HY-70068

SB-408124	Antagonist	98.27%
SB-408124 is a non-peptide OX1 receptor antagonist with K_is of 57 nM and 27 nM in whole cell and membrane, respectively.

HY-10895

SB-334867	Antagonist	99.44%
SB-334867 (SB 334867A) is an excellent,selective and blood–brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 (pK_b=7.4), 100-fold over 5-HT_2B, 5-HT_2C with pK_i values of 5.4 and 5.3, respectively.

HY-108683

ACT-335827	Antagonist	≥98.0%
ACT-335827 is a selective, orally active, brain-penetrant orexin type 1 receptor antagonist.

HY-76612

SB-408124 Hydrochloride	Antagonist	98.09%
SB-408124 Hydrochloride is a selective non-peptide orexin receptor 1 (OX1) receptor antagonist with K_is of 57 nM and 27 nM in whole cell and membrane, respectively.

HY-P1340A

[Ala11,D-Leu15]-Orexin B(human) TFA	Agonist
[Ala11,D-Leu15]-Orexin B(human) TFA is a potent and selective orexin-2 receptor (OX2) agonist.

HY-P1341

OXA(17-33)	Agonist	98.63%
OXA(17-33) is a potent and selective orexin-1 receptor (OX1) agonist.

HY-P1341A

OXA(17-33) TFA	Agonist
OXA(17-33) TFA is a potent and selective orexin-1 receptor (OX1) agonist.

HY-146517

Orexin receptor antagonist 4	Antagonist
Orexin receptor antagonist 4 is potent and selective orexin 2 receptor (OX2R) antagonist with an IC₅₀ of 4.27 nM.

HY-P1340

[Ala11,D-Leu15]-Orexin B(human)	Agonist	98.04%
[Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist.

HY-134188

JNJ-54717793	Antagonist	98.85%
JNJ-54717793, as a brain penetrant, is an orally active, selective and high affinity orexin-1 receptor (OX1R) antagonist (plasma EC₅₀=85 ng/mL).

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