PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
-
PROTAC Linkers Related Products (4102)
Related Products (4102)
-
PROTAC Linkers Isoform Comparison
-
m-PEG3-Sulfone-PEG3-acid
0 ImagesCat. No.: HY-140605CAS No.: 1919045-04-7
-
Bis-propargyl-PEG6
0 ImagesCat. No.: HY-117186CAS No.: 400775-35-1Bis-propargyl-PEG6 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG6 can be used to synthesize the polymer linked multimers of guanosine-3', 5'-cyclic monophosphates. Bis-propargyl-PEG6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
-
Biotin-PEG23-azide
0 ImagesCat. No.: HY-140913Biotin-PEG23-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG23-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
-
Hydroxy-PEG2-CH2COONa
0 ImagesCat. No.: HY-140497ACAS No.: 42588-76-1Synonyms: HO-PEG2-CH2COONa
-
m-PEG3-Propanoyl chloride
0 ImagesCat. No.: HY-140505CAS No.: 66722-87-0
-
Benzyl-PEG3-amine
0 ImagesCat. No.: HY-W190795CAS No.: 86770-75-4
-
Thiol-PEG3-phosphonic acid ethyl ester
0 ImagesCat. No.: HY-141319CAS No.: 1360716-43-3
-
Propargyl-PEG5-PFP ester
0 ImagesCat. No.: HY-132043CAS No.: 2148295-92-3
-
Butoxycarbonyl-PEG5-sulfonic acid
0 ImagesCat. No.: HY-140175CAS No.: 1817735-28-6
-
6-Hydroxy-1-(4-(2-hydroxyethyl)piperazin-1-yl)hexan-1-one
0 ImagesCat. No.: HY-168686CAS No.: 2859434-39-0
-
Suberic acid-13C2
0 ImagesCat. No.: HY-W015300S2CAS No.: 2251773-62-1Synonyms: Octanedioic acid-13C2Suberic acid-13C2 (Octanedioic acid-13C2) is the 13C-labeled Suberic acid (HY-W015300). Suberic acid (Octanedioic acid) is an orally active crystalline dibasic acid. Suberic acid activates the Akt signaling pathway and regulates the expression of molecules related to the TGF-β and MAPK signaling pathways. Suberic acid inhibits skin dryness.
-
Hydroxy-PEG7-Boc
0 ImagesCat. No.: HY-141204CAS No.: 2737223-20-8
-
6-Bromohexylphosphonic acid
0 ImagesCat. No.: HY-140329CAS No.: 133345-66-1
-
Mal-PEG8-Boc
0 ImagesCat. No.: HY-133212CAS No.: 2055048-43-4
