2. PROTAC
  3. PROTAC Linkers
  4. Mal-PEG8-Boc

Mal-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Mal-PEG8-Boc Chemical Structure

Mal-PEG8-Boc Chemical Structure

CAS No. : 2055048-43-4

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50 mg USD 160 In-stock
100 mg USD 260 In-stock
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Based on 1 publication(s) in Google Scholar

Mal-PEG8-Boc Related Antibodies

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Description

Mal-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mal-PEG8-Boc Related Antibodies
Molecular Weight

577.66

Formula

C27H47NO12
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCOCCOCCOCCN1C(C=CC1=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (173.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7311 mL 8.6556 mL 17.3112 mL
5 mM 0.3462 mL 1.7311 mL 3.4622 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7311 mL 8.6556 mL 17.3112 mL 43.2781 mL
5 mM 0.3462 mL 1.7311 mL 3.4622 mL 8.6556 mL
10 mM 0.1731 mL 0.8656 mL 1.7311 mL 4.3278 mL
15 mM 0.1154 mL 0.5770 mL 1.1541 mL 2.8852 mL
20 mM 0.0866 mL 0.4328 mL 0.8656 mL 2.1639 mL
25 mM 0.0692 mL 0.3462 mL 0.6924 mL 1.7311 mL
30 mM 0.0577 mL 0.2885 mL 0.5770 mL 1.4426 mL
40 mM 0.0433 mL 0.2164 mL 0.4328 mL 1.0820 mL
50 mM 0.0346 mL 0.1731 mL 0.3462 mL 0.8656 mL
60 mM 0.0289 mL 0.1443 mL 0.2885 mL 0.7213 mL
80 mM 0.0216 mL 0.1082 mL 0.2164 mL 0.5410 mL
100 mM 0.0173 mL 0.0866 mL 0.1731 mL 0.4328 mL
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Mal-PEG8-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mal-PEG8-Boc2055048-43-4PROTAC LinkersInhibitorinhibitorinhibit

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