PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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BnO-PEG5-Boc
0 ImagesCat. No.: HY-140749CAS No.: 1807537-31-0
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m-PEG36-OH
0 ImagesCat. No.: HY-133287CAS No.: 2633587-48-9
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Amino-PEG10-acid
0 ImagesCat. No.: HY-140176CAS No.: 2170987-85-4
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m-PEG4-O-NHS ester
0 ImagesCat. No.: HY-141113CAS No.: 147912-03-6
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Biotin-bis-amido-SS-NHS
0 ImagesCat. No.: HY-130490CAS No.: 142439-92-7
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Propenyl-PEG3-Propenyl
0 ImagesCat. No.: HY-134676CAS No.: 90736-68-8Synonyms: Triethylene glycol diallyl ether
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2-(2-Aminoethoxy)ethyl hydrogen carbonate
0 ImagesCat. No.: HY-176952CAS No.: 2999731-11-02-(2-Aminoethoxy)ethyl hydrogen carbonate is a PROTAC linker. 2-(2-Aminoethoxy)ethyl hydrogen carbonate can be used in the synthesis of OZD-MET 01 (HY-177893).
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Boc-PEG1-PPG2-C2-NH2
0 ImagesCat. No.: HY-138485CAS No.: 3026669-94-0
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Bis-(Mal-PEG3)-PH-N-succinimidyl acetate
0 ImagesCat. No.: HY-138519CAS No.: 2512228-01-0
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Benzyloxy carbonyl-PEG3-C2-acid
0 ImagesCat. No.: HY-140745CAS No.: 2100306-73-6
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SCO-PEG4-COOH
0 ImagesCat. No.: HY-156387CAS No.: 2141976-27-2
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Acid-PEG3-PFP ester
0 ImagesCat. No.: HY-140511CAS No.: 1835759-67-5
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Diethyl 7-bromoheptylphosphonate
0 ImagesCat. No.: HY-W035417CAS No.: 100462-73-5
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Mal-amino-sulfo
0 ImagesCat. No.: HY-136168CAS No.: 158018-81-6
