Potassium Channel
KcsA
Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.
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Potassium Channel Inhibitors
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Potassium Channel Agonists
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Potassium Channel Antagonists
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Potassium Channel Activators
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Potassium Channel Modulators
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Potassium Channel Chemical
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Potassium Channel Controls
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Potassium Channel Related Products (1142)
Related Products (1142)
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Antibodies (6)
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Related Compound Screening Libraries (1)
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TRAM-39
0 ImagesTRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IKCa) channels. TRAM-39 inhibits KCa3.1 channel with an IC50 value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease.
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Clobutinol hydrochloride
0 ImagesClobutinol hydrochloride is a compound that has anti-tussive effects. Clobutinol hydrochloride affects heart rate and blood pressure, it can be used for cough related research.
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ML399
0 ImagesML399 is a Menin-MLL1 protein-protein interaction inhibitor with an IC50 of 90 nM. ML399 inhibits the proliferation of transformed mouse bone marrow cells. ML399 binds to the hERG potassium channel, exhibits superior in vitro physicochemical, drug metabolism and pharmacokinetic (DMPK) parameters, and has an extended half-life in rodents. ML399 can be used for research on acute myeloid leukemia and acute lymphoblastic leukemia.
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Hydrochlorothiazid-13C,d2
0 ImagesCat. No.: HY-B0252S1CAS No.: 1190006-03-1Synonyms: HCTZ-13C,d2Hydrochlorothiazid-13C,d2 is the 13C- and deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect.
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Vernakalant-d6 hydrochloride
0 ImagesSynonyms: RSD1235-d6 hydrochlorideVernakalant-d6 (hydrochloride) is deuterium labeled Vernakalant.
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N-Salicyloyltryptamine
0 ImagesCat. No.: HY-147377CAS No.: 31384-98-2N-Salicyloyltryptamine acts on voltage-dependent Na+, Ca2+, and K+ ion channels inhibitor. N-Salicyloyltryptamine inhibits K+ currents with an IC50 value of 34.6 μM (Ito). N-Salicyloyltryptamine also exhibits anticonvulsant, anti-inflammatory, analgesic, and vasorelaxation effect-.
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MK-0448
0 ImagesMK-0448 is a specific Kv1.5 inhibitor used in the research of atrial fibrillation.
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Nateglinide-d5
0 ImagesSynonyms: A4166 d5; Senaglinide d5Nateglinide-d5 is a deuterium labeled Nateglinide. Nateglinide, a D-phenylalanine derivative, is an orally active and short-acting insulinotropic agent and a DPP IV inhibitor. Nateglinide inhibits ATP-sensitive K+ channels in pancreatic β-cells. Nateglinide is used for the treatment of type 2 (non-insulin-dependent) diabetes mellitus[1][2].
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Guanfu base A
0 ImagesGuanfu base A is an antiarrhythmic alkaloid isolated from Aconitum coreanum and is a potent noncompetitive CYP2D6 inhibitor, with a Ki of 1.20 μM in human liver microsomes (HLMs) and a Ki of 0.37 μM for the human recombinant form (rCYP2D6). Guanfu base A is also a potent competitive inhibitor of CYP2D in monkey (Ki of 0.38 μM) and dog (Ki of 2.4 μM) microsomes. Guanfu base A also inhibits HERG channel current.
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Gliquidone-d6
0 ImagesCat. No.: HY-B1114SSynonyms: AR-DF 26-d6Gliquidone-d6 (AR-DF 26-d6) is the deuterated-labeled Gliquidone (HY-B1114). Gliquidone can bind to the pancreatic β-cells and increases insulin release to regulate blood glucose levels. Gliquidone significantly decreases LPS (HY-D1056)-induced proinflammatory responses and inhibits ERK/STAT3/NF-κB phosphorylation in BV2 microglial cells. Gliquidone can suppress microgliosis, microglial hypertrophy mediated by LPS, and proinflammatory cytokine COX-2 and IL-6 levels in murine model. Gliquidone also exhibits good anticancer activity in lung carcinoma cells. Gliquidone has antioxidant property. Gliquidone can be studied in research for type 2 diabetes and cancers.
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Naluzotan
0 ImagesSynonyms: PRX 00023Naluzotan is a novel, potent, and selective amidosulfonamide 5-HT1A agonist with IC50 and Ki of appr 20 nM and 5.1 nM, used for the treatment of anxiety and depression; Also a weak hERG K+ channel blocker, with IC50 of 3800 nM.
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Flonicamid-15N18O
0 ImagesSynonyms: IKI220-15N18OFlonicamid-15N,18O (IKI220-15N,18O) is the 18O , 15N-labeled Flonicamid (HY-119649). Flonicamid (IKI220) is an antifeedant Insecticide active against Hemiptera, Thysanoptera, and piercing-sucking pests including aphids of all species, developmental stages and morphs. Flonicamid inhibits the inward rectifier potassium channel NlKir1, blocking stylet penetration, salivation, sap feeding, honeydew secretion, and fluid secretion by isolated Malpighian tubules. Flonicamid reduces renal excretory function in female Culex pipiens pallens. Flonicamid rapidly disrupts insect feeding behavior without neurotoxic poisoning symptoms, induces irreversible starvation, and increases the mortality of nymph progeny of adult aphids exposed to this agent.
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KCNQ1 activator-1
0 ImagesKCNQ1 activator-1 (compound 5) is a potent activator of KCNQ1 channel with an EC50 of 1.69 μM. KCNQ1 activator-1 has the potential for the research of long QT syndrome (LQTS).
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Guangxitoxin 1E
0 ImagesGuangxitoxin 1E is a potent and selective blocker of KV2.1 and KV2.2 channels. Guangxitoxin 1E inhibits KV2 with an IC50 of 1-3 nM. KV2 channels underlie delayed-rectifier potassium currents in various neurons.
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3-Chlorodiphenylamine
0 Images3-Chlorodiphenylamine is a high affinity Ca2+ sensitizer of cardiac muscle. 3-Chlorodiphenylamine is based on diphenylamine and binds to the isolated N-domain of cardiac troponin C (cTnC) (Kd=6 µM). 3-Chlorodiphenylamine is an excellent starting scaffold for the development of more potent Ca2+-sensitizing compounds due to its small size, and can be used for systolic heart failure research.
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1,12-Dodecanediamine
0 ImagesCat. No.: HY-W014883CAS No.: 2783-17-7Synonyms: 1,12-DD; 1,12-Diamino dodecane1,12-Dodecanediamine (1,12-DD) is a reversible Maxi calcium-activated potassium channel blocker. 1,12-Dodecanediamine can reduce the single-channel current amplitude, mean channel open time, and channel open probability. 1,12-Dodecanediamine is promising for research of cell electrical signal transduction mechanism.
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Carabersat
0 ImagesSynonyms: SB-204269Carabersat is a potent anticonvulsant agent.
