1233152-82-3
Chemical Structure
Guangxitoxin 1E
- CAS No.: 1233152-82-3
- Formula:C178H248N44O45S7
- Molecular Weight:3948.61
SMILES: O=C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CSSC[C@@H](C(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@H]3C(C)C)=O)=O)=O)=O)NC4=O)C(NCC(NCC(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CC6=CNC7=CC=CC=C67)C(N[C@@H](CC8=CNC9=CC=CC=C89)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CO)C(N%10[C@@H](CCC%10)C(N[C@@H](CCCCN)C(N[C@@H](CC(/C%11=C/C)=CNC%11=C)C(NCC(N[C@H]%12CC(C)C)=O)=O)=O)=O)=O)=O)NC3=O)C(NCC(N[C@@H](CO)C(NCC(N[C@@H](CCCCN)C(N%13[C@@H](CCC%13)C(N[C@@H](C)C(N[C@H]4CSSC[C@@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CC%14=CC=CC=C%14)C(N%15[C@@H](CCC%15)C(N[C@@H](CCSC)C(N%16[C@@H](CCC%16)C(O)=O)=O)=O)=O)=O)=O)NC%12=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(O)=O)N
Biological Activity: Guangxitoxin 1E is a potent and selective blocker of KV2.1 and KV2.2 channels. Guangxitoxin 1E inhibits KV2 with an IC50 of 1-3 nM. KV2 channels underlie delayed-rectifier potassium currents in various neurons[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Guangxitoxin 1E | 98.82% | Guangxitoxin 1E is a potent and selective blocker of KV2.1 and KV2.2 channels. Guangxitoxin 1E inhibits KV2 with an IC50 of 1-3 nM. KV2 channels underlie delayed-rectifier potassium currents in various neurons. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Hönigsperger C, et al. Physiological roles of Kv2 channels in entorhinal cortex layer II stellate cells revealed by Guangxitoxin-1E. J Physiol. 2017 Feb 1;595(3):739-757. [Content Brief]
- [2]. Herrington J, et al. Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion. Diabetes. 2006 Apr;55(4):1034-42. [Content Brief]
