C-Raf Ligand
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14-3-3σ/CRAF stabilizer-1
0 ImagesCat. No.: HY-190255CAS No.: 3091137-87-714-3-3σ/CRAF stabilizer-1 (compound 10) is a molecular glue stabilizer of the protein-protein interaction between 14-3-3σ and CRAF. 14-3-3σ/CRAF stabilizer-1 stabilizes the 14-3-3σ/CRAF complex by covalently binding to Cys38 of 14-3-3σ, preventing CRAF from forming active dimers and thereby inhibiting the MAPK signaling pathway. 14-3-3σ/CRAF stabilizer-1 can be used for research on K-RAS-driven cancers.
