Sirtuin
Sirtuin (Sir2 proteins) are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in bacteria, archaeaand eukaryotes. Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Sirtuins can also control circadian clocks and mitochondrial biogenesis.
Sirtuin Isoform Specific Products
All Product Categories
-
Sirtuin Inhibitors
(168)
View all products
-
Sirtuin Agonists
(11)
View all products
-
Sirtuin Activators
(101)
View all products
-
Sirtuin Modulators
(12)
View all products
-
Sirtuin Degraders
(3)
View all products
-
Sirtuin Control
(1)
View all products
-
Sirtuin Substrates
(4)
View all products
-
Sirtuin Ligand
(1)
View all products
-
Sirtuin Related Products (320)
Related Products (320)
-
Antibodies (9)
-
Sirtuin Isoform Comparison
-
SIRT6 modulator-1
0 ImagesCat. No.: HY-186009CAS No.: 339156-78-4
-
SIRT3-IN-2
0 ImagesCat. No.: HY-118109CAS No.: 848688-62-0
-
3-TYP (Standard)
0 ImagesCat. No.: HY-108331RCAS No.: 120241-79-43-TYP (Standard) is the analytical standard of 3-TYP (HY-108331). This product is intended for research and analytical applications. 3-TYP is an inhibitor of SIRT3 (IC50of 38 μM) and an inhibitor of Methionine Adenosyltransferase (MAT) 2 and Indoleamine 2,3-Dioxygenase (IDO). There may be many off-target sites for 3-TYP that need to be examined, such as NAD-dependent enzymes, including dehydrogenases.
-
Salermide (Standard)
0 ImagesCat. No.: HY-101073RCAS No.: 1105698-15-4
-
SIRT2-IN-15
0 ImagesCat. No.: HY-159126CAS No.: 312275-43-7SIRT2-IN-15 (compound 1) is a SIRT2 deacetylase and deamyloacylase inhibitor with IC50 7 and 37 μM, respectively.
-
PROTAC Sirt2 Degrader-1 (Standard)
0 ImagesCat. No.: HY-103636RCAS No.: 2098487-75-1PROTAC Sirt2 Degrader-1 (Standard) is the analytical standard of PROTAC Sirt2 Degrader-1 (HY-103636). This product is intended for research and analytical applications. PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s>100 μM).
-
SIRT1-IN-6
0 ImagesCat. No.: HY-174299CAS No.: 1174387-32-6
-
Perindopril-d3 erbumine
0 ImagesCat. No.: HY-B0130ASSynonyms: Perindopril-d3 (tert-butylamine salt); S-9490-d3 erbuminePerindopril-d3 (erbumine) is deuterated labeled Perindopril (erbumine) (HY-B0130A). Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NF-κB and STAT3 signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure.
-
3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol
0 ImagesCat. No.: HY-N9398CAS No.: 97744-95-1
-
5-Heptadecylresorcinol (Standard)
0 ImagesCat. No.: HY-N2673RCAS No.: 41442-57-3Synonyms: 5-n-Heptadecylresorcinol (Standard); AR-C17 (Standard)5-Heptadecylresorcinol (AR-C17), a phenolic lipid component, is also an orally active mitochondrial protector. 5-Heptadecylresorcinol improves mitochondrial function via sirtuin3 signaling pathway, thus alleviates endothelial cell damage and apoptosis. 5-Heptadecylresorcinol induces sirtuin3-mediated autophagy. 5-Heptadecylresorcinol reduces the atherosclerotic plaques in the aortic root region of mice heart. 5-Heptadecylresorcinol can be used for research of atherosclerosis prevention and obesity.
-
Z-MAL
0 ImagesCat. No.: HY-176545CAS No.: 642463-22-7
-
SRT 1720 monohydrochloride (Standard)
0 ImagesSRT 1720 (monohydrochloride) (Standard) is the analytical standard of SRT 1720 (monohydrochloride). This product is intended for research and analytical applications. SRT 1720 monohydrochloride is a selective and orally active activator of SIRT1 with an EC50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3.
-
Phellopterin (Standard)
0 ImagesPhellopterin (Standard) is the analytical standard of Phellopterin. Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus.
-
Thiomyristoyl (Standard)
0 ImagesCat. No.: HY-101278RCAS No.: 1429749-41-6Thiomyristoyl (Standard) is the analytical standard of Thiomyristoyl (HY-101278). This product is intended for research and analytical applications. Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM.
-
Gamma-glutamylcysteine ammonium
0 ImagesCat. No.: HY-113402BSynonyms: γ-Glu-Cys ammoniumGamma-glutamylcysteine ammonium (γ-Glu-Cys ammonium) is an orally active, blood-brain barrier permeable dipeptide. Gamma-glutamylcysteine ammonium activates AMPK, SIRT1, IL-4/STAT6, AC/cAMP/PI3K, IGF-1R/IRS1/PI3K, and Nrf2 signaling pathways; it inhibits NF-κB, JAK1/STAT1/3, MAPKs, cadmium-induced p38 MAPK, JNK, and PI3K/Akt signaling pathways. Gamma-glutamylcysteine ammonium regulates macrophage polarization, modulates the trafficking of CD36 and GLUT4, induces glutathione synthesis, improves metabolic dysfunction, reduces lipid deposition, ameliorates glucose homeostasis, inhibits apoptosis (Apoptosis), stabilizes mitochondria, suppresses lipid peroxidation, iron accumulation and ferroptosis (Ferroptosis), reduces ds-HMGB1 levels, reverses mechanical hyperalgesia, and alleviates hepatic lipid droplet formation. Gamma-glutamylcysteine ammonium is applicable to research related to inflammatory bowel disease, type 2 diabetes, cadmium-induced neurotoxicity, Alzheimer's disease, cerebral ischemia/reperfusion injury, neuropathy, and alcoholic liver disease.
-
CAY10602 (Standard)
0 ImagesCat. No.: HY-104073RCAS No.: 374922-43-7
-
SIRT6-IN-2 (Standard)
0 ImagesSIRT6-IN-2 (Standard) is the analytical standard of SIRT6-IN-2 (HY-103721). This product is intended for research and analytical applications. SIRT6-IN-2 (Compound 5) is a selective and competitive SIRT6 inhibitor (IC50: 34 μM). SIRT6-IN-2 increases acetylation of H3K9 and increases glucose uptake in cultured cells. SIRT6-IN-2 also reduces T cell proliferation. SIRT6-IN-2 has immunosuppressive and chemosensitizing effects.
-
Cambinol (Standard)
0 ImagesCambinol (Standard) is the analytical standard of Cambinol. This product is intended for research and analytical applications. Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 μM and 59 μM, respectively. Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
