2. Signaling Pathways
  3. Apoptosis
  4. Survivin
  5. Survivin Degrader

Survivin Degrader

Survivin Degraders (2):

Cat. No. Product Name Effect Purity
  • HY-12842
    UC-112
    		Degrader 98.92%
    UC-112 is a XIAP inhibitor with anticancer activity. UC-112 selectively downregulates and degrades survivin via the ubiquitin-mediated proteasomal degradation pathway. UC-112 reduces XIAP levels in in vivo tumor models. UC-112 activates caspase-3/7 and caspase-9, and induces cancer cell apoptosis. UC-112 is applicable to studies on melanoma, prostate cancer and cancer-related research.
  • HY-186212
    PROTAC survivin degrader-1
    		Degrader
    PROTAC survivin degrader-1 is an orally active, CNS-penetrant survivin-targeting PROTAC. PROTAC survivin degrader-1 induces degradation of survivin via the ubiquitin proteasome system. PROTAC survivin degrader-1 can be used for the research of glioblastoma.