country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-187584

Copy Link Print Information

LQZ-7

LQZ-7 is a survivin inhibitor and molecular glue degrader (K_d=0.24 μM). LQZ-7 binds to the dimerization interface of survivin, disrupting homodimerization and dissociating dimeric survivin into monomers, thereby accelerating its proteasome-dependent degradation. LQZ-7 does not affect the structurally similar dimeric proteins 14-3-3σ and 14-3-3δ, and can induce apoptosis, exhibiting cytotoxicity against cancer cells.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1044664-73-4
分子式: C₂₄H₁₉N₇O₄
分子量:469.45

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

LQZ-7 構造式

CAS 番号: 1044664-73-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
PC-3	IC50	25 μM	Inhibitory concentration 50% against human PC-3 cancer cells assessed as reduction in cell survival incubated for 3 days by MTT assay. Inhibitory concentration 50% against human PC-3 cancer cells assessed as reduction in cell survival incubated for 3 days by MTT assay.	26744521
DU-145	IC50	25 μM	Inhibitory concentration 50% against human DU145 cancer cells assessed as reduction in cell survival incubated for 3 days by MTT assay. Inhibitory concentration 50% against human DU145 cancer cells assessed as reduction in cell survival incubated for 3 days by MTT assay.	26744521

体外実験

Bacterial InfectionAnti-cancerApoptosis

Bacterial Infection

LQZ-7 (30 min) dissociates existing dimeric survivin^[1].
LQZ-7 (25 µM; 3 days) inhibits survival of PC-3 and DU145 cells with an IC₅₀ of ~25 µM^[1].

Anti-cancer

LQZ-7 (10 µM; 24 hours) induced survivin loss in PC-3 cells is reversed by proteasome inhibitors^[1].
LQZ-7 induces proteasome-dependent degradation of survivin in cancer cells^[2].

Apoptosis

Anti-cancer

LQZ-7 (20 μM) binds to survivin, disrupts survivin dimerization, and accelerates proteasome-dependent degradation of survivin, exhibiting cytotoxicity against Du145 and PC3 cells with an IC₅₀ of ~25 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

DU145 and PC-3
Concentration:

25 µM
Incubation Time:

3 days
Result:

Inhibited survival of human PC-3 and DU145 cells with an IC50 of ~25 µM.

Western Blot Analysis^[1]

Cell Line:

PC-3
Concentration:

10 µM
Incubation Time:

24 hours
Result:

Induced survivin loss that was reversed by co-treatment with a proteasome inhibitor, MG132 or bortezomib.

体内実験

Anti-cancer

LQZ-7F (25 mg/kg; i.p.; every 3 days; 8 doses) effectively inhibits the growth of PC-3 xenograft tumors in vivo by inducing apoptosis and reducing survivin levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NOD/SCID (male, 4-6 weeks old)^[1]
Dosage:

25 mg/kg
Administration:

i.p.; every 3 days; 8 doses
Result:

Inhibited the growth of PC-3 xenograft tumors compared to the vehicle control.
Reduced final average tumor weight significantly compared to the control group.
Maintained constant body weight after multiple dosings.
Induced apoptosis, showing more apoptotic cells with condensed chromatin.
Dramatically reduced survivin levels as determined by Western blot and immunohistochemistry.

Related Protocols :

化学情報

CAS 番号 1044664-73-4
分子量 469.45
分子式 C₂₄H₁₉N₇O₄
SMILES

OC(C1=CC=CC(C2=CC=C(O2)/C=N/NC3=NC4=NON=C4N=C3NC5=C(C(C)=CC=C5)C)=C1)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Qi J, et al. Effective Targeting of the Survivin Dimerization Interface with Small-Molecule Inhibitors. Cancer research. 2016 Jan 15;76(2):453-62.

[2]. Martínez-García D, et al. Therapeutic strategies involving survivin inhibition in cancer. Medicinal research reviews. 2019 May;39(3):887-909.

[3]. Li F, et al. Cancer therapeutics using survivin BIRC5 as a target: what can we do after over two decades of study?. Journal of experimental & clinical cancer research : CR. 2019 Aug 22;38(1):368.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

LQZ-7

生物活性

製品説明

Cellular Effect

体外実験

体内実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Bioz

Keywords

最近チェックした製品

LQZ-7

生物活性

製品説明

Cellular Effect

体外実験

体内実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

LQZ-7 関連分類

HY-187584 関連分類

Bioz

Keywords

最近チェックした製品