2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. VDAC
  5. VDAC1 Isoform
  6. VDAC1 Ligand

VDAC1 Ligand

VDAC1 Ligand (1):

Cat. No. Product Name Effect Purity
  • HY-181529
    NCATS-SM0225
    		Ligand
    NCATS-SM0225 is an endoplasmic reticulum-associated degradation (ERAD) inhibitor and a direct binder of VDAC1, VDAC2 and VDAC3. NCATS-SM0225 exhibits an IC50of 1.02 μM for ERAD and a Kd of 3.13 μM for human VDAC1 binding. NCATS-SM0225 disrupts cellular calcium homeostasis, enhances VDAC1-IP3R coupling and activating PERK. NCATS-SM0225 selectively kills cancer cells, exhibits tumor growth inhibitory effects in melanoma xenograft models. NCATS-SM0225 can be used for research on multiple cancers including melanoma, as well as the molecular mechanisms of ERAD and calcium homeostasis regulation.