Vasopressin Receptor Inhibitor
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AGN-190851
0 ImagesCat. No.: HY-165456CAS No.: 134892-42-5AGN-190851 is a potent and selective agonist of α2-adrenergic receptor (α2 adrenoceptor). AGN-190851 induces dose-dependent water diuresis in rats, and inhibits vasopressin V2 receptor in a species-dependent manner in vitro, thereby suppressing cAMP production. AGN-190851 enhances the contraction of porcine myometrium. AGN 190851 can be used in studies on renal diuretic mechanisms, pharmacology of α2-adrenergic receptor subtypes, and parturition.
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Imidafenacin
0 ImagesSynonyms: KRP-197; ONO-8025Imidafenacin (KRP-197; ONO-8025) is an orally active inhibitor of muscarinic (mAChR) M1 and M3 receptors. Imidafenacin potently inhibits bladder contraction in vivo and exerts an antidiuretic effect by enhancing the signaling pathway of vasopressin (antidiuretic hormone). Imidafenacin can be used in research related to overactive bladder.
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2-Guanidinobezimidazole
0 ImagesCat. No.: HY-W158030CAS No.: 5418-95-1Synonyms: 2GBI2-Guanidinobezimidazole (2GBI) is a NLRP3 agonist with a KD of 1.29 μM and a selective state-dependent HVCN1 blocker. 2-Guanidinobezimidazole directly binds NLRP3’s LRR domain, enhances NLRP3-ASC and NLRP3-NEK7 interactions, and drives NLRP3 inflammasome activation. 2-Guanidinobezimidazole can be used for the research of LLC lung carcinoma, B16F10 melanoma and ischemic stroke.
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Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol
0 ImagesCat. No.: HY-W583271CAS No.: 119700-81-1Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol is a heme oxygenase (HO) inhibitor, and inhibiting HO activity can reduce the release of hypothalamic hormones like AVP, OT, and ANP caused by hyperosmolarity. Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol can be used for research on hyperbilirubinemia.
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F992
0 ImagesCat. No.: HY-P0041CAS No.: 162277-99-8F992 is an antidiuretic peptide and vasopressin (antidiuretic hormone) analogue.
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Pecavaptan
0 ImagesCat. No.: HY-109133CAS No.: 1914998-56-3Synonyms: BAY 1753011Pecavaptan, a chemical probe, is an orally active and dual antagonist of V1a/V2 receptor (Ki=0.5 nM and 0.6 nM for human, respectively). Pecavaptan promotes an increase in urine production, which reduces the associated symptoms of water retention and edema.
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Imidafenacin hydrochloride
0 ImagesCat. No.: HY-B0662ACAS No.: 893421-54-0Synonyms: KRP-197 hydrochloride; ONO-8025 hydrochlorideImidafenacin (KRP-197; ONO-8025) hydrochloride is an orally active inhibitor of muscarinic (mAChR) M1 and M3 receptors. Imidafenacin hydrochloride potently inhibits bladder contraction in vivo and exerts an antidiuretic effect by enhancing the signaling pathway of vasopressin (antidiuretic hormone). Imidafenacin hydrochloride can be used in research related to overactive bladder.
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[Deamino-Pen1,Val4,D-Arg8]-vasopressin
![[Deamino-Pen1,Val4,D-Arg8]-vasopressin](https://file.medchemexpress.com/product_pic/hy-p10046.gif "Click to View [Deamino-Pen1,Val4,D-Arg8]-vasopressin Product Detail")
0 ImagesCat. No.: HY-P10046CAS No.: 64158-84-5[Deamino-Pen1,Val4,D-Arg8]-vasopressin (AVP-A) is an arginine-vasopressin (AVP) antagonist. AVP-A can significantly lower plasma aldosterone concentration in rats. AVP-A can be used for the research of the growth and steroidogenic capacity of rat adrenal zona glomerulosa.
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DM-4111
0 ImagesCat. No.: HY-165423CAS No.: 926035-36-1DM-4111, one of the major monohydroxyl metabolites of Tolvaptan (HY-17000), is a potent vasopressin V2 receptor inhibitor. DM-4111 inhibits water reabsorption in the renal tubules, thereby promoting the excretion of electrolyte-free water. DM-4111 is promising for research of cardiovascular diseases.
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