5418-95-1
5418-95-1
Chemical Structure
2-Guanidinobezimidazole
Synonym(s): 2GBI
- CAS No.: 5418-95-1
- Formula:C8H9N5
- Molecular Weight:175.19
IUPAC Name: 2-(1H-benzo[d]imidazol-2-yl)guanidine
InChIKey: JJWCTKUQWXYIIU-UHFFFAOYSA-N
SMILES: N/C(N)=N/C1=NC2=CC=CC=C2N1
Biological Activity: 2-Guanidinobezimidazole (2GBI) is a NLRP3 agonist with a KD of 1.29 μM and a selective state-dependent HVCN1 blocker. 2-Guanidinobezimidazole directly binds NLRP3’s LRR domain, enhances NLRP3-ASC and NLRP3-NEK7 interactions, and drives NLRP3 inflammasome activation. 2-Guanidinobezimidazole can be used for the research of LLC lung carcinoma, B16F10 melanoma and ischemic stroke[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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2-Guanidinobezimidazole | 95.74% | 2-Guanidinobezimidazole (2GBI) is a NLRP3 agonist with a KD of 1.29 μM and a selective state-dependent HVCN1 blocker. 2-Guanidinobezimidazole directly binds NLRP3’s LRR domain, enhances NLRP3-ASC and NLRP3-NEK7 interactions, and drives NLRP3 inflammasome activation. 2-Guanidinobezimidazole can be used for the research of LLC lung carcinoma, B16F10 melanoma and ischemic stroke. | ||||||||||||||||||||
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References
- [1]. Liu X, et al. A small molecule directly targets NLRP3 to promote inflammasome activation and antitumor immunity. Cell Death Dis. 2025;16(1):252. Published 2025 Apr 4. [Content Brief]
- [2]. Zhao C, et al. A novel Hv1 inhibitor reveals a new mechanism of inhibition of a voltage-sensing domain. J Gen Physiol. 2021;153(9):e202012833. [Content Brief]
