Xanthine Oxidase
XO
Xanthine oxidase (XO), a versatile molybdoflavoprotein, catalyzes the oxidative hydroxylation of purine substrates (hypoxanthine and xanthine) to produce uric acid and subsequent reduction of oxygen at the flavin center with the generation of reactive oxygen species, either superoxide anion radical or hydrogen peroxide.
Xanthine oxidase is an important enzyme of purine catabolism pathway and has been associated directly in pathogenesis of gout and indirectly in many pathological conditions like cancer, diabetes and metabolic syndrome. The selective inhibition of xanthine oxidase may result in a broad spectrum therapeutic use for gout, cancer, inflammation and oxidative damage.
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Xanthine Oxidase Related Products (159)
Related Products (159)
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Antibodies (1)
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Xanthine oxidase-IN-20
0 ImagesCat. No.: HY-180186CAS No.: 3069916-11-3Xanthine oxidase-IN-20 is a potent and orally active xanthine oxidase (XO) inhibitor with an IC50 of 1.7 nM. Xanthine oxidase-IN-20 exhibits outstanding serum uric acid (SUA)-lowering efficacy in both mouse and rat acute hyperuricemia models. Xanthine oxidase-IN-20 shows favorable safety profile. Xanthine oxidase-IN-20 can be used for hyperuricemia and gout research.
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Isorhamnetin-3-O-neohespeidoside (Standard)
0 ImagesCat. No.: HY-N0778RCAS No.: 55033-90-4Isorhamnetin-3-O-neohespeidoside (Standard) is the analytical standard of Isorhamnetin-3-O-neohespeidoside (HY-N0778). This product is intended for research and analytical applications. Isorhamnetin-3-O-neohespeidoside is a flavonoid. Isorhamnetin-3-O-neohespeidoside can be isolated from Typha angustifolia. Isorhamnetin-3-O-neohespeidoside inhibits xanthine oxidase activity with an IC50 of 48.75 μg mL. Isorhamnetin-3-O-neohespeidoside has antioxidant and osteoclastogenic activities. Isorhamnetin-3-O-neohespeidoside can be used in research of bone.
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Cholesterol oxidase, Streptomyces sp.
0 ImagesCat. No.: HY-P2848BSynonyms: ChOx, Streptomyces sp.Cholesterol oxidase, Streptomyces sp. (ChOx, Streptomyces sp.) (EC 1.1.3.6) is a cholesterol oxidase identified from bacterial sources. Cholesterol oxidase, Streptomyces sp. catalyzes the oxidation of cholesterol to 4-cholesten-3-one, while simultaneously reducing oxygen to hydrogen peroxide. Cholesterol oxidase, Streptomyces sp. retains its enzymatic activity and exhibits improved catalytic efficiency upon immobilization. Cholesterol oxidase, Streptomyces sp. is applicable for cholesterol detection, steroid biotransformation, and research on tuberculosis-related diseases.
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2′-C-Methyl-6-O-methylinosine
0 ImagesCat. No.: HY-154017CAS No.: 565450-78-42′-C-Methyl-6-O-methylinosine is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.
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Ilexoside O
0 ImagesCat. No.: HY-N9324CAS No.: 136552-23-3Ilexoside O is a triterpene saponin isolated from the roots of Ilex pubescens. Ilexoside O exhibits weak xanthine oxidase (XOD) inhibitory activity (IC50=53.05 μM).
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CC15009
0 ImagesCat. No.: HY-162882CAS No.: 2482713-67-5CC15009 is a xanthine oxidoreductase (XOR) inhibitor, with an IC50 value of 0.237 nM. CC15009 can inhibit the oxidative subtype of XOR, thereby reducing the production of the byproduct ROS and exhibiting antioxidant activity. CC15009 has demonstrated a good dose-dependent uric acid-lowering effect in two different mouse models of hyperuricemia induced by XOR substrates.
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Febuxostat acyl glucuronide
0 ImagesCat. No.: HY-129889CAS No.: 1351692-92-6Synonyms: Febuxostat acyl-β-D-glucuronideFebuxostat acyl glucuronide (Febuxostat acyl-β-D-glucuronide) is a metabolite of Febuxostat (HY-14268). Febuxostat is a potent, selective and non-purine xanthine oxidase (XO) inhibitor.
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Smilaxchinoside A
0 ImagesCat. No.: HY-N17914CAS No.: 935530-84-0Smilaxchinoside A is an orally active steroidal glycoside found in the roots of S. riparia. Smilaxchinoside A reduces serum uric acid levels and shows potent uricosuric activity. Smilaxchinoside A inhibits XOD activity and downregulates renal mURAT1 expression. Smilaxchinoside A can be used for the research of hyperuricemia.
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Cholesterol oxidase, Pseudomonas sp.
0 ImagesCat. No.: HY-P2848CSynonyms: ChOx, Pseudomonas sp.Cholesterol oxidase, Pseudomonas sp. (ChOx, Pseudomonas sp.) (EC 1.1.3.6) is a cholesterol oxidase identified from bacterial sources. Cholesterol oxidase, Pseudomonas sp. catalyzes the oxidation of cholesterol to 4-cholesten-3-one, while simultaneously reducing oxygen to hydrogen peroxide. Cholesterol oxidase, Pseudomonas sp. retains its enzymatic activity and exhibits improved catalytic efficiency upon immobilization. Cholesterol oxidase, Pseudomonas sp. is applicable for cholesterol detection, steroid biotransformation, and research on tuberculosis-related diseases.
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Fraxamoside
0 ImagesCat. No.: HY-N3906CAS No.: 326594-34-7Fraxamoside is a competitive xanthine oxidase inhibitor with an IC50 of 16.1 μM and a Ki of 0.9 μM.
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CV 3611
0 ImagesCat. No.: HY-106797CAS No.: 98829-12-0CV 3611 is a potent and orally active free radical scavenger. CV 3611 shows anti-inflammatory, antiarrhythmic and anticancer effects. CV 3611 can be used for the researches of cancer, inflammation and cardiovascular disease, such as hepatocellular carcinoma and acute pancreatitis.
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Aurantiamide benzoate
0 ImagesAurantiamide benzoate is a nature product that could be isolated from two tropical medicinal plants, Cunila spicata and Hyptis fasciculata. Aurantiamide benzoate is a potent xanthine oxidase inhiobitor with an IC50 value of 70 μM.
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Xanthine oxidase-IN-24
0 ImagesCat. No.: HY-189143Xanthine oxidase-IN-24 is an orally active mixed-type inhibitor of xanthine oxidase, with an IC50 of 0.051 μM and a Ki of 0.162 μM. Xanthine oxidase-IN-24 interacts with both free xanthine oxidase and the xanthine-xanthine oxidase complex, and reduces uric acid production in vivo. In a rat model of hyperuricemia induced by Potassium oxonate (HY-17511), Xanthine oxidase-IN-24 dose-dependently lowers serum uric acid levels, improves renal function-related biochemical parameters such as creatinine and urea nitrogen, and alleviates histopathological damage to liver and kidney tissues. Xanthine oxidase-IN-24 can be used in the research of hyperuricemia.
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Xanthine oxidoreductase-IN-3
0 ImagesCat. No.: HY-151973CAS No.: 651769-78-7Xanthine oxidoreductase-IN-3 is an orally active xanthine oxidoreductase (XOR) inhibitor, with an IC50 of 26.3 nM. Xanthine oxidoreductase-IN-3 can be used for the research of acute hyperuricemia.
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Xanthine oxidase-IN-5
0 ImagesCat. No.: HY-144456CAS No.: 2276711-87-4Xanthine oxidase-IN-5 is an effective and orally active xanthine oxidase (XO) inhibitor with IC50 value of 0.70 μM. Xanthine oxidase-IN-5 displays favorable agent-like properties with ligand efficiency (LE) and lipophilic ligand efficiency (LLE) values of 0.33 and 3.41, respectively. Xanthine oxidase-IN-5 shows potent hypouricemic effects in hyperuricemic rat model.
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Xanthine oxidase-IN-18
0 ImagesCat. No.: HY-178342Xanthine oxidase-IN-18 is a potent orally activeXanthine oxidase (XO) inhibitor (IC50 = 0.263 μM). Xanthine oxidase-IN-18 exerts inhibition by directly and stably binding to the xanthine oxidase Mo-co active site. Xanthine oxidase-IN-18 exhibits reactive oxygen species (ROS) scavenging activity. Xanthine oxidase-IN-18 shows anti-hyperuricemia effects in a Potassium oxonate (HY-17511)-induced hyperuricemic rat model. Xanthine oxidase-IN-18 can be used for hyperuricemia, breast and lung cancer research.
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Imidazole-15N2
0 ImagesSynonyms: Glyoxaline-15N2; 1,3-Diaza-2,4-cyclopentadiene-15N2Imidazole-15N2 (Glyoxaline-15N2) is 15N labeled Imidazole. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CLPro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease.
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Oxypurinol-13C3,15N3
0 ImagesCat. No.: HY-19657S1Synonyms: Oxipurinol-13C3,15N3Oxypurinol-13C3,15N3 (Oxipurinol-13C3,15N3) is the 13C- and 15N-labeled Oxypurinol (HY-19657). Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout.
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Forsythoside F
0 ImagesSynonyms: ArenariosideForsythoside F (Arenarioside) is a xanthine oxidase inhibitor and possesses antihyperuricemic effects in vivo.
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Xanthine oxidase-IN-17
0 ImagesCat. No.: HY-175303CAS No.: 185522-92-3Xanthine oxidase-IN-17 is a potent xanthine oxidase (XOD) inhibitor with an IC50 of 298 nM and a Ki of 167 nM. Xanthine oxidase-IN-17 decreases the formation of O₂⁻ radical by inhibiting the catalytic activity of XOD to diminish the production of uric acid. Xanthine oxidase-IN-17 shows no cytotoxicity in AML-12 hepatocytes, while suppressing uric acid production. Xanthine oxidase-IN-17 can be used for the studies of hyperuricemia and subsequently to gout.
