Xanthine Oxidase
XO
Xanthine oxidase (XO), a versatile molybdoflavoprotein, catalyzes the oxidative hydroxylation of purine substrates (hypoxanthine and xanthine) to produce uric acid and subsequent reduction of oxygen at the flavin center with the generation of reactive oxygen species, either superoxide anion radical or hydrogen peroxide.
Xanthine oxidase is an important enzyme of purine catabolism pathway and has been associated directly in pathogenesis of gout and indirectly in many pathological conditions like cancer, diabetes and metabolic syndrome. The selective inhibition of xanthine oxidase may result in a broad spectrum therapeutic use for gout, cancer, inflammation and oxidative damage.
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Xanthine Oxidase Related Products (158)
Related Products (158)
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Antibodies (1)
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Xanthine oxidase-IN-12
0 ImagesCat. No.: HY-156360CAS No.: 3041062-80-7Xanthine oxidase-IN-12 (Compound 11) is a xanthine oxidase (XO) inhibitor with an IC50 of 91 nM. Xanthine oxidase-IN-12 also has antioxidant activity and reduces intracellular ROS.
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XOR/URAT1-IN-1
0 ImagesCat. No.: HY-161523CAS No.: 2810137-86-9XOR/URAT1-IN-1 (Compound II15) is a dual inhibitor for xanthine oxidoreductase (XOR) and uric acid transporter 1 (URAT1), with IC50 of 6 nM and 12.9 μM. XOR/URAT1-IN-1 lowers the levels of uric acid in Potassium oxonate (HY-17511)/Hypoxanthine (HY-N0091)-induced acute hyperuricemia mouse model.
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2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite
0 Images2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.
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Eupatoriochromene
0 ImagesEupatoriochromene is a chromene and has inhibitory activity against xanthine oxidase (XO).
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Baicalein 6-O-glucoside
0 ImagesCat. No.: HY-N8352CAS No.: 28279-72-3Baicalein 6-O-glucoside is a glucuronidation metabolite of Baicalein.
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Xanthine oxidoreductase-IN-1
0 ImagesCat. No.: HY-146296CAS No.: 2396612-00-1The compound is a xanthine oxidoreductase (XOR) inhibitor with high inhibitory concentration, and the value of ic50 is 7.0 nm.
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6-Methoxypurine-9-β-D-5’(R)-C-methylriboside
0 ImagesCat. No.: HY-1526786-Methoxypurine-9-β-D-5’(R)-C-methylriboside is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.
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Xanthine oxidase-IN-8
0 ImagesCat. No.: HY-N10432CAS No.: 2571069-66-2Synonyms: Icarisids JXanthine oxidase-IN-8 (Icarisids J) (Compound 7) is a XOD inhibitor with an IC50 of 29.71 μM.
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Cholesterol oxidase, Nocardia sp.
0 ImagesCat. No.: HY-P2848DSynonyms: ChOx, Nocardia sp.Cholesterol oxidase, Nocardia sp. (ChOx, Nocardia sp.) (EC 1.1.3.6) is a cholesterol oxidase identified from bacterial sources. Cholesterol oxidase, Nocardia sp. catalyzes the oxidation of cholesterol to 4-cholesten-3-one, while simultaneously reducing oxygen to hydrogen peroxide. Cholesterol oxidase, Nocardia sp. retains its enzymatic activity and exhibits improved catalytic efficiency upon immobilization. Cholesterol oxidase, Nocardia sp. is applicable for cholesterol detection, steroid biotransformation, and research on tuberculosis-related diseases.
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Febuxostat impurity 6
0 ImagesCat. No.: HY-131271CAS No.: 1271738-74-9Febuxostat impurity 6 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
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Angexostat
0 ImagesCat. No.: HY-177070CAS No.: 2640653-91-2Angexostat (Compound 2) is an inhibitor of xanthine oxidase. Angexostat exhibits high permeability. Angexostat inhibits CYP2C9 with an IC50 of 18.1 μM. Angexostat can be studied in research for xanthine oxidase-related diseases such as hyperuricemia and gout.
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Xanthine oxidase-IN-6
0 ImagesCat. No.: HY-146560Xanthine oxidase-IN-6 (Compound 6c) is a potent, orally active, mixed-type xanthine oxidase (XOD) inhibitor with an IC50 value of 1.37 µM. Xanthine oxidase-IN-6 shows strong anti-hyperuricemia and renal protective activity.
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XO/COX/LOX-IN-1
0 ImagesCat. No.: HY-151173CAS No.: 2831329-35-0XO/COX/LOX-IN-1 is a XO/COX/LOX inhibitor with an IC50 of 3.2 μM against rat XO, 10.83 μM against 5-LOX, 12.67 μM against COX-1, and 8.31 μM against COX-2. XO/COX/LOX-IN-1 binds to the active sites of XO, 5-LOX, COX-1 and COX-2, thereby blocking enzyme activities associated with uric acid, leukotriene, prostaglandin synthesis and inflammatory pathways. XO/COX/LOX-IN-1 can be used in the research of hyperuricemia and inflammation.
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Xanthine oxidoreductase-IN-4
0 ImagesCat. No.: HY-151974CAS No.: 1026587-58-5Xanthine oxidoreductase-IN-4 is an orally active xanthine oxidoreductase (XOR) inhibitor. Xanthine oxidoreductase-IN-4 has inhibitory activity against XOR with an IC50 value of 29.3 nM. Xanthine oxidoreductase-IN-4 can be used for the research of hyperuricemia.
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Ellagic acid 4-O-β-D-xylopyranoside
0 ImagesCat. No.: HY-N10741CAS No.: 139163-18-1Ellagic acid 4-O-β-D-xylopyranoside is a natural ellagitannin with antimicrobial activity. Ellagic acid 4-O-β-D-xylopyranoside is an xanthine oxidase inhibitor with an 50 of 2.1 μg/mL.
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Xanthine oxidase-IN-10
0 ImagesCat. No.: HY-150257CAS No.: 851429-65-7Xanthine oxidase-IN-10 (XO8 analog) is an xanthine oxidase (XO) inhibitor.
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6-O-Methylinosine
0 Images6-O-Methylinosine is a hypoxanthine analogue. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.
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(+/-)-Epicatechin
0 ImagesCat. No.: HY-W104467CAS No.: 13392-26-2Synonyms: (+/-)-Epicatechol; (+/-)-epi-Catechin(+/-)-Epicatechin is a xanthine oxidase inhibitor with an IC50 of 982.14 μM, and can be found in Semen Plantaginis (Plantago seed). (+/-)-Epicatechin can be used in research on diseases such as hyperuricemia and gout .
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Tetrahydroamentoflavone
0 ImagesCat. No.: HY-N1162CAS No.: 48236-96-0Synonyms: AmentoflavanoneTetrahydroamentoflavone (Amentoflavanone) is a potent xanthine oxidase (XO) inhibitor. Tetrahydroamentoflavone has inhibitory activity for XO with IC50 and Ki values of 92 nM and 0.982 μM, respectively. Tetrahydroamentoflavone can be used for the research of inflammatory disorders and gout.
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Xanthine oxidase-IN-9
0 ImagesCat. No.: HY-N10433CAS No.: 2571069-61-7Synonyms: Icarisids EXanthine oxidase-IN-9 (Icarisids E) (Compound 2) is a potent xanthine oxidase (XOD) inhibitor with an IC50 of 31.81 μM.
