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Cat. No.: HY-180186

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Xanthine oxidase-IN-20

Xanthine oxidase-IN-20 is a potent and orally active xanthine oxidase (XO) inhibitor with an IC₅₀ of 1.7 nM. Xanthine oxidase-IN-20 exhibits outstanding serum uric acid (SUA)-lowering efficacy in both mouse and rat acute hyperuricemia models. Xanthine oxidase-IN-20 shows favorable safety profile. Xanthine oxidase-IN-20 can be used for hyperuricemia and gout research.

For research use only. We do not sell to patients.

CAS No.: 3069916-11-3
Formula: C₂₁H₂₂N₆O₆
Molecular Weight:454.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Xanthine oxidase-IN-20 Chemical Structure

CAS No.: 3069916-11-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Xanthine oxidase-IN-20 (compound Z29) (72 h) exhibit no obvious toxicity tohuman vascular endothelial cells (VE) and human umbilical vein endothelial cells (HUVEC) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Parmacokinetics

Species	Dose	Route	AUC_0-t	AUC_0-inf	MRT_{INF_obs}	T_1/2	T_max	C_max	CL	F
Rat^[1]	1 mg/kg	i.v.	580 ng·h/mL	610 ng·h/mL	2.46 h	6.9 h	0.083 h	1633 ng/mL	27.3 mL/min/kg	/
Rat^[1]	4 mg/kg	p.o.	80.4 ng·h/mL	130 ng·h/mL	8.23 h	6.0 h	0.25 h	59.9 ng/mL	/	5.32 %

In Vivo

Xanthine oxidase-IN-20 (compound Z29) (0.5, 2.25, 4, and 5mg/kg, p.o., single dose) decreases SUA in hyperuricemia mouse and rat models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3069916-11-3
Molecular Weight 454.44
Formula C₂₁H₂₂N₆O₆
SMILES

OC(C1=CN(C2=CC=C(C(N3N=NN=C3)=C2)O[C@H]4CO[C@]5([C@@]4(OC[C@@H]5OCC(C)=C)[H])[H])N=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zeng X, et al. Novel Isoidide Subunit-Containing Xanthine Oxidase Inhibitors with Potent Hypouricemic Effects. J Med Chem. 2025 Dec 11;68(23):25416-25437. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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