2. Metabolic Enzyme/Protease
  3. Xanthine Oxidase
  4. Xanthine oxidase-IN-20

Xanthine oxidase-IN-20 is a potent and orally active xanthine oxidase (XO) inhibitor with an IC50 of 1.7 nM. Xanthine oxidase-IN-20 exhibits outstanding serum uric acid (SUA)-lowering efficacy in both mouse and rat acute hyperuricemia models. Xanthine oxidase-IN-20 shows favorable safety profile. Xanthine oxidase-IN-20 can be used for hyperuricemia and gout research.

For research use only. We do not sell to patients.

Xanthine oxidase-IN-20

Xanthine oxidase-IN-20 Chemical Structure

CAS No. : 3069916-11-3

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Xanthine oxidase-IN-20 Related Antibodies

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Description

Xanthine oxidase-IN-20 is a potent and orally active xanthine oxidase (XO) inhibitor with an IC50 of 1.7 nM. Xanthine oxidase-IN-20 exhibits outstanding serum uric acid (SUA)-lowering efficacy in both mouse and rat acute hyperuricemia models. Xanthine oxidase-IN-20 shows favorable safety profile. Xanthine oxidase-IN-20 can be used for hyperuricemia and gout research[1].

In Vitro

Xanthine oxidase-IN-20 (compound Z29) (72 h) exhibit no obvious toxicity tohuman vascular endothelial cells (VE) and human umbilical vein endothelial cells (HUVEC) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Xanthine oxidase-IN-20 Related Antibodies
Parmacokinetics
Species Dose Route AUC0-t AUC0-inf MRTINF_obs T1/2 Tmax Cmax CL F
Rat[1] 1 mg/kg i.v. 580 ng·h/mL 610 ng·h/mL 2.46 h 6.9 h 0.083 h 1633 ng/mL 27.3 mL/min/kg /
Rat[1] 4 mg/kg p.o. 80.4 ng·h/mL 130 ng·h/mL 8.23 h 6.0 h 0.25 h 59.9 ng/mL / 5.32 %
In Vivo

Xanthine oxidase-IN-20 (compound Z29) (0.5, 2.25, 4, and 5mg/kg, p.o., single dose) decreases SUA in hyperuricemia mouse and rat models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

454.44

Formula

C21H22N6O6
CAS No.
SMILES

OC(C1=CN(C2=CC=C(C(N3N=NN=C3)=C2)O[C@H]4CO[C@]5([C@@]4(OC[C@@H]5OCC(C)=C)[H])[H])N=C1)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Xanthine oxidase-IN-20 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Xanthine oxidase-IN-203069916-11-3Xanthine OxidaseXOxanthine oxidaseserum uric acidhyperuricemiagoutendothelial cellshuman umbilical vein endothelial cellsInhibitorinhibitorinhibit

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