2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. ATP-binding cassette (ABC) transporters
  5. ATP-binding cassette (ABC) transporters Substrate

ATP-binding cassette (ABC) transporters Substrate

ATP-binding cassette (ABC) transporters Substrate (1):

Cat. No. Product Name Effect Purity
  • HY-N7755
    Estradiol 3-glucuronide sodium
    		Substrate 98%
    Estradiol 3-glucuronide sodium is an estrogen metabolite, which is a glucuronide conjugate formed by the catalysis of uridine diphosphate glucuronosyltransferase in tissues such as the liver from Estradiol (HY-B0141). Estradiol 3-glucuronide sodium is a potent substrate of Mrp2, with an S50 of 55.7 μM. Estradiol 3-glucuronide sodium achieves hepatobiliary transport in hepatocytes through basolateral uptake via OATP1B1, OATP1B3 and OATP2B1, as well as apical efflux via MRP2 and BCRP.