ATP-binding cassette (ABC) transporters Substrate

Estradiol 3-glucuronide sodium is an estrogen metabolite, which is a glucuronide conjugate formed by the catalysis of uridine diphosphate glucuronosyltransferase in tissues such as the liver from Estradiol (HY-B0141). Estradiol 3-glucuronide sodium is a potent substrate of Mrp2, with an S₅₀ of 55.7 μM. Estradiol 3-glucuronide sodium achieves hepatobiliary transport in hepatocytes through basolateral uptake via OATP1B1, OATP1B3 and OATP2B1, as well as apical efflux via MRP2 and BCRP.

Nitroxynil is a broad-spectrum veterinary anthelmintic and a substrate of ABCG2. Nitroxynil inhibits ATP production by uncoupling the oxidative phosphorylation process of mitochondria, thereby disrupting the parasite body covering, impairing its motility, and ultimately inducing parasite death. Nitroxynil induces chromosomal aberrations, sister chromatid exchanges and abnormal sperm morphology, and interferes with spermatogenesis. Nitroxynil is widely applicable to studies on fascioliasis, myiasis, Haemonchus spp. infections, and Oestrus ovis infections.