2. Signaling Pathways
  3. Neuronal Signaling
  4. Choline Kinase
  5. CHKα Isoform
  6. CHKα Inhibitor

CHKα Inhibitor

CHKα Inhibitors (2):

Cat. No. Product Name Effect Purity
  • HY-120337
    V-11-0711
    		Inhibitor 98.54%
    V-11-0711 is a potent and selective Chk-α (IC50 = 20 nM) inhibitor. V-11-0711 can significantly reduce PCho levels. V-11-0711 causes a reversible growth arrest. V-11-0711 induces apoptosis at high concentrations. V-11-0711 can be used for the study of cervical cancer and triple-negative breast cancer.
  • HY-101145
    CK37
    		Inhibitor
    CK37 is a competitive choline kinase-α inhibitor. CK37 inhibits purified recombinant human choline kinase-α activity. CK37 suppresses MAPK and PI3K/AKT signaling, disrupts actin cytoskeletal organization. CK37 diminishs activating phosphorylations of ERK. CK37 exhibits anticancer activity against cervical cancer, melanoma, Lewis lung carcinoma, lung adenocarcinoma, breast cancer, and leukemia.