2. Signaling Pathways
  3. Anti-infection
  4. Dengue Virus

Dengue Virus

DENV

Dengue virus (DENV) belongs to the Flaviviridae family and is a small enveloped virus with a single-stranded positive-sense RNA of about 11kb in length and a granular spherical shape. DENV contains 4 serotypes: DENV serotype 1, DENV-2, DENV-3 and DENV-4. Envelope Protein E, NS3, NS5, etc. are effective targets for DENV inhibitors, which work by blocking viral entry, inhibiting protein processing and replication, and interfering with RNA capping. NS4B inhibitors can also disrupt related effects and inhibit the formation of viral replication complexes.

Dengue Virus Related Products (159):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-156074
    Erythromycin propionate
    		Inhibitor
    Erythromycin propionate, erythromycin (HY-B0220) derivative, is a macrolide antibiotic used in the treatment of a wide variety of bacterial infections. Erythromycin propionate causes several cases of liver injury which mostly include cholestatic hepatitis. Erythromycin propionate toxicity is related to its inhibitory effect on bile acid transport.
    Erythromycin propionate
  • HY-181920
    RPG-01-132
    		Inhibitor
    RPG-01-132 is a DENV capsid protein PROTAC degrader, with a DC50 of 2.4 μM. RPG-01-132 blocks viral assembly, eliminates viral particles, and interferes with the non-structural functions of capsid protein. RPG-01-132 exhibits significant antiviral activity against all four DENV serotypes and the ST148 (HY-121663)-resistant DENV2 mutant strain. RPG-01-132 is applicable to research related to dengue virus infection.
    RPG-01-132
  • HY-W011100R
    Cyclofenil (Standard)
    		Inhibitor
    Cyclofenil (Standard) is the analytical standard of Cyclofenil. This product is intended for research and analytical applications. Cyclofenil is a selective estrogen receptor modulator and an ovulation-inducing agent. Cyclofenil shows an inhibitory effect on dengue virus replication in Vero cells with an EC50 of 1.62 μM. Cyclofenil has anti-dengue-virus activity.
    Cyclofenil (Standard)
  • HY-161804
    GNF-2-deg
    		Degrader
    GNF-2-deg is a PROTAC degrader for dengue virus envelope protein (DENV E protein) with DC50 of 0.83 μM. GNF-2-deg prevents viral entry by inhibiting E-mediated membrane fusion, prevents virion production by protein degradation, and thereby exhibits antiviral activity against DENV 2 with EC90 of 3.5 μM. GNF-2-deg exhibits antiviral activity against ZIKV, JEV, WNV and YFV with EC90 of 1.96-7.79 μM. (Pink: ligand for target protein (HY-161805); Black: linker (HY-42149); Blue: ligand for E3 ligase (HY-23095))
    GNF-2-deg
  • HY-161808
    DENV ligand 2
    DENV ligand 2 is the ligand for DENV E protein.DENV ligand 2 can be utilized for synthesis of PROTAC Degrader ZXH-8-004 (HY-161806). DENV ligand 2 is the active form of DENV ligand 1 (HY-161807).
    DENV ligand 2
  • HY-159879
    AAK1-IN-6
    		Inhibitor
    AAK1-IN-6 (Compound 23) is an inhibitor of AP-2-associated protein kinase 1 (AAK1, IC50 = 12 nM) with antiviral activity against the dengue virus (DNEV2, EC50 = 0.24 μM) and Venezuelan equine encephalitis virus (VEEV, EC50 = 0.30 μM). AAK1-IN-6 can be utilized in antiviral research.
    AAK1-IN-6
  • HY-B1120R
    Temephos (Standard)
    		Inhibitor
    Temephos (Standard) is the analytical standard of Temephos. This product is intended for research and analytical applications. Temephos (Temefos) is an orally active, blood-brain barrier-permeable organophosphate insecticide and AChE inhibitor. By irreversibly inhibiting AChE to induce cholinergic overactivation, Temephos effectively blocks larval development of Aedes aegypti (yellow fever mosquito) and Aedes albopictus (Asian tiger mosquito), and is commonly used in studies related to Dengue Virus, Zika Virus and other relevant pathogens. Temephos exhibits genotoxicity and neurodevelopmental toxicity, and may also cause liver injury, reproductive system abnormalities and cholinergic poisoning symptoms in mammals. Temephos tends to accumulate in adipose tissues and aquatic organisms, and is excreted via feces after metabolism through oxidation and hydrolysis. Note that CYP-mediated metabolic detoxification may reduce the actual larvicidal efficacy of Temephos against some mosquito species. Temephos can be used in research related to dengue fever, Zika virus disease, chikungunya and dracunculiasis.
    Temephos (Standard)
  • HY-182042
    DENV-IN-15
    		Inhibitor
    DENV-IN-15 is a sulfonyl anthranilic acid derivative and a pan-serotype anti-dengue virus (DENV) inhibitor with broad-spectrum anti-RNA virus activity. The EC50 value of DENV-IN-15 against DENV-2 in Huh-7 cells is 0.7 μM. DENV-IN-15 selectively regulates the translation of mRNAs encoding translation-related proteins and containing a 5'-oligopyrimidine tract. DENV-IN-15 reduces the expression of specific ribosomal proteins, thereby inhibiting viral replication. DENV-IN-15 exhibits enhanced membrane permeability, human plasma stability and human liver microsomal metabolic stability. DENV-IN-15 is applicable to research related to dengue virus infection.
    DENV-IN-15
  • HY-W841708
    5-((1H-Indol-3-yl)methylene)imidazolidine-2,4-dione
    		Inhibitor
    5-((1H-Indol-3-yl)methylene)imidazolidine-2,4-dione is an inhibitor of dengue virus NS2B-NS3 protease and thrombin. 5-((1H-Indol-3-yl)methylene)imidazolidine-2,4-dione can be used in the research of infectious diseases.
    5-((1H-Indol-3-yl)methylene)imidazolidine-2,4-dione
  • HY-P990817
    Anti-West Nile/dengue virus E protein Antibody (E60)
    		Inhibitor
    Anti-West Nile/dengue virus E protein Antibody (E60) is mouse-derived IgG2a κ type antibody inhibitor, targeting to West Nile/dengue virus E protein. Anti-West Nile/dengue virus E protein Antibody (E60) can cross-neutralize West Nile virus (WNV) and dengue virus (DENV) envelope (E) protein. Anti-West Nile/dengue virus E protein Antibody (E60) can be used for the researches of WNV and DENV infection.
    Anti-West Nile/dengue virus E protein Antibody (E60)
  • HY-17043S3
    Loratadine-13C6
    		Inhibitor
    Loratadine-13C6 (SCH 29851-13C6) is 13C labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.
    Loratadine-<sup>13</sup>C<sub>6</sub>
  • HY-124224
    D4-Ribavirin
    		Inhibitor
    D4-Ribavirin (Compound 4) is a deoxygenated ribavirin analogue. D4-Ribavirin has antiviral property in vitro against the RNA-containing bunyaviruses–Rift Valley Fever () with an IC50 of 61 μg/mL.
    D4-Ribavirin
  • HY-131379
    ZX-2401
    		Inhibitor
    ZX-2401 (Compound 98a) is a 1,3,5-Triazine-based analogue of Purine (HY-34431). ZX-2401 has a significant antiviral activity against viruses of the Flaviviridae family, such as West Nile Virus (WNV), Hepatitis C (HCV), Yellow Fever Virus (YFV), Dengue Virus (DV), Bovine Viral Diarrhea Virus (BVDV) and Banzi Virus (BV) with EC90s of 0.6-10 μg/mL. ZX-2401 significantly reduces virus production with an EC90 of 3.3 mg/mL. ZX-2401 can be used for influenza infections research.
    ZX-2401
  • HY-179722
    MTase-IN-2
    		Inhibitor
    MTase-IN-2 (compound 32) is a potent NS5 methyltransferase inhibitor with IC50s of 2.14 μM and 2.01 μM against the Dengue virus (DENV3) MTase domain and Zika virus (ZIKV) NS5 MTase domain, respectively.
    MTase-IN-2
  • HY-N0434R
    Astragaloside III (Standard)
    		Inhibitor
    Astragaloside III (Standard) is the analytical standard of Astragaloside III (HY-N0434). This product is intended for research and analytical applications. Astragaloside III is a triterpenoid saponin. Astragaloside III can be extracted from Astragalus root. Astragaloside III increases NKG2D and induces TACE phosphorylation. Astragaloside III induces Apoptosis. Astragaloside III has antiviral activity against dengue serotypes 1 and 3. Astragaloside III has anticancer activity against breast and colon cancer.
    Astragaloside III (Standard)
  • HY-107433R
    U18666A (Standard)
    		Inhibitor
    U18666A (Standard) is the analytical standard of U18666A (HY-107433). This product is intended for research and analytical applications. U18666A, an intra-cellular cholesterol transport inhibitor, inhibits replication of Ebola virus, dengue virus, and human hepatitis C virus.
    U18666A (Standard)
  • HY-178994
    DENV-IN-14
    		Inhibitor
    DENV-IN-14 (Compound 3c) is a thiazole hydrazone derivative with anti-dengue virus (DENV) activity with an EC50 of 0.01 μM and the selectivity index (SI) of 200. DENV-IN-14 exhibits rapid plasma clearance and its metabolic stability is limited. DENV-IN-14 can be used for research on dengue fever.
    DENV-IN-14
  • HY-100540BR
    Golgicide A-2 (Standard)
    		Inhibitor
    Golgicide A-2 (Standard) is the analytical standard of Golgicide A-2 (HY-100540B). This product is intended for research and analytical applications. Golgicide A-2 (GCA-2), a Golgicide A (GCA) derivative, is the most active enantiomer of GCA. Golgicide A-2 displays high selectivity and efficiency in killing An. stephensi larvae and can be used for the research of dengue virus related diseases.
    Golgicide A-2 (Standard)
  • HY-106991
    Amustaline
    		Inhibitor
    Amustaline (S-303) is a compound used for inactivating pathogens in blood components and belongs to the category of nucleic acid-targeted chemical decontaminants. Amustaline has the ability to inactivate viruses and is effective against mosquito-borne viruses such as Chikungunya virus (CHIKV), Dengue virus (DENV), and Zika virus (ZIKV). When combined with glutathione (Glutathione, GSH), which acts as a neutralizer to counteract adverse reactions, Amustaline ensures the stability of red blood cell membranes. Amustaline is mainly used for inactivating pathogens in red blood cell concentrates (RBCC) to reduce the risk of transfusion-transmitted infections (TTI).
    Amustaline