Dihydropyrimidine Dehydrogenase (DPD) Inhibitor
-
5-Iodouracil
0 Images5-Iodouracil (Compound 4b) is an irreversible dihydropyrimidine dehydrogenase (DPD) inhibitor (IC50=0.22 μM). 5-Iodouracil is promising for research of DPD-overexpressing solid tumors like non-small cell lung cancer (NSCLC).
-
Ro-09-4889
0 ImagesCat. No.: HY-19413CAS No.: 216449-60-4Ro-09-4889 is a prodrug. Ro-09-4889 can inhibit dihydropyrimidine dehydrogenase (DPD) activity and its effect is dose-dependent. Ro-09-4889 can be used for cancer research.
-
DFP-11207
0 ImagesCat. No.: HY-114249CAS No.: 1296177-16-6DFP-11207 is an orally active fluoropyrimidine cytotoxic agent. DFP-11207 combines a 5-FU (HY-90006) pro-drug with a reversible DPD inhibitor and a potent inhibitor of OPRT, resulting in enhanced pharmacological activity of 5-FU with decreased gastrointestinal and myelosuppressive toxicities. DFP-11207 can be used for the research of cancer .
