2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Dihydropyrimidine Dehydrogenase (DPD)
  5. Dihydropyrimidine Dehydrogenase (DPD) Inhibitor

Dihydropyrimidine Dehydrogenase (DPD) Inhibitor

Dihydropyrimidine Dehydrogenase (DPD) Inhibitors (3):

Cat. No. Product Name Effect Purity
  • HY-W001983
    5-Iodouracil
    		Inhibitor 99.95%
    5-Iodouracil (Compound 4b) is an irreversible dihydropyrimidine dehydrogenase (DPD) inhibitor (IC50=0.22 μM). 5-Iodouracil is promising for research of DPD-overexpressing solid tumors like non-small cell lung cancer (NSCLC).
  • HY-19413
    Ro-09-4889
    		Inhibitor
    Ro-09-4889 is a prodrug. Ro-09-4889 can inhibit dihydropyrimidine dehydrogenase (DPD) activity and its effect is dose-dependent. Ro-09-4889 can be used for cancer research.
  • HY-114249
    DFP-11207
    		Inhibitor
    DFP-11207 is an orally active fluoropyrimidine cytotoxic agent. DFP-11207 combines a 5-FU (HY-90006) pro-drug with a reversible DPD inhibitor and a potent inhibitor of OPRT, resulting in enhanced pharmacological activity of 5-FU with decreased gastrointestinal and myelosuppressive toxicities. DFP-11207 can be used for the research of cancer .