2. Signaling Pathways
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  4. Drug Derivative

Drug Derivative

Drug derivative

Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.

Drug Derivative Related Products (3809):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-133513
    (±)-H3RESCA-TFP
    (±)-H3RESCA-TFP ((±)-H3L28) is a tetrafluorophenyl ester derivative of restrained complexing agent (RESCA). (±)-H3RESCA-TFP can be used to conjugate the chelator with a biomolecule via amine coupling (e.g., N terminus and/or the ε-amino groups of lysine).
    (±)-H3RESCA-TFP
  • HY-W002304
    (R)-5-Oxopyrrolidine-2-carboxylic acid
    		98.0%
    (R)-5-Oxopyrrolidine-2-carboxylic acid (D-Pyroglutamic acid) is a cyclic derivative of D-glutamate. (R)-5-Oxopyrrolidine-2-carboxylic acid can be used in the research of metabolic syndrome and end-stage renal disease.
    (R)-5-Oxopyrrolidine-2-carboxylic acid
  • HY-128742
    Thiamine monophosphate chloride dihydrate
    		99.24%
    Thiamine monophosphate chloride dihydrate is a vitamin B1 (HY-A0100) metabolite and thiamine precursor. Thiamine monophosphate chloride dihydrate is absorbable in vivo and can be converted into thiamine. Thiamine monophosphate chloride dihydrate can be used as a food additive.
    Thiamine monophosphate chloride dihydrate
  • HY-17484
    Ampiroxicam
    		98.73%
    Ampiroxicam is an orally active prodrug of non-steroidal anti-inflammatory drug (NSAID). Ampiroxicam inhibits paw swelling in adjuvant-induced arthritis and acute inflammation models, and suppresses phenylbenzoquinone-induced stretching responses in mice. Ampiroxicam is rapidly and completely converted to Piroxicam (HY-B0253) via non-specific esterases and first-pass metabolism. Ampiroxicam induces contact hypersensitivity and photosensitivity reactions through photoproducts generated by UVA. Ampiroxicam can be used in research related to photosensitivity, adjuvant-induced arthritis, rheumatism, osteoarthritis and other inflammatory diseases.
    Ampiroxicam
  • HY-W777986
    1-Eicosapentaenoyl-sn-glycerol-3-phosphocholine
    		98.87%
    1-Eicosapentaenoyl-sn-glycerol-3-phosphocholine (1-EPA-2-OH-sn-glycerol-3-phosphocholine) is an ester product.
    1-Eicosapentaenoyl-sn-glycerol-3-phosphocholine
  • HY-128775
    JHU395
    		99.69%
    JHU395 is an orally-bioavailable and a plasma stable lipophilic glutamine antagonists (GA) proagent. JHU395 delivers 6-diazo-5-oxo-L-norleucine (DON) to malignant peripheral nerve sheath tumor (MPNST) in vitro and in vivo, and has antitumor activity in MPNST.
    JHU395
  • HY-114231
    Exaluren
    		98.0%
    Exaluren (ELX-02; NB-124) is an synthetic eukaryotic ribosome-selective glycoside that induces read-through of nonsense mutations, resulting in normally localized full-length functional proteins. Exaluren is used for the research of cystic fibrosis caused by nonsense mutations.
    Exaluren
  • HY-111179
    ML261
    		99.67%
    ML261 is a hepatic lipid droplets formation inhibitor with an IC50 value of 69.7 nM. ML261 can be used for the research of non-alcoholic fatty liver disease (NAFLD) and inflammation.
    ML261
  • HY-153182
    GBT1118
    		99.97%
    GBT1118 is a potent and orally active allosteric modifier of hemoglobin oxygen affinity. GBT1118 increases tolerance to severe hypoxia.
    GBT1118
  • HY-W105735
    1,16-Hexadecanediol
    		99.93%
    1,16-Hexadecanediol (Hexadecamethylene glycol) is an ester product.
    1,16-Hexadecanediol
  • HY-160610A
    Carbamoyl phosphate dilithium salt
    Carbamoyl phosphate dilithium salt is an antisickling agent and plays a significant role in the urea cycle. Carbamoyl phosphate dilithium salt carbamylates the amino-terminal valine residues of hemoglobin S in erythrocytes, which interferes with the sickling phenomenon. Carbamoyl phosphate dilithium salt exhibits toxicity due to the lithium cation.
    Carbamoyl phosphate dilithium salt
  • HY-B1442
    Acetylleucine
    		99.40%
    Acetylleucine (N-Acetyl-DL-leucine), orally active compound, can be used for the research of acute vestibular vertigo, cerebellar ataxia and nystagmus.
    Acetylleucine
  • HY-I0450
    Anticancer agent 265
    		99.64%
    Anticancer agent 265 (compound 1) is an anticancer compound. Anticancer agent 265 exhibits in vitro anticancer activity against three human bone cancer lines, U2OS, Saos-2, and GC9811, with IC50 values ​​of 13.1, 11.7, and 14.6 μM, respectively.
    Anticancer agent 265
  • HY-124124S
    N-Methylnicotinamide-d4
    		98.23%
    N-Methylnicotinamide-d4 is the deuterium labeled N-Methylnicotinamide (HY-124124). N-Methylnicotinamide is an endogenous metabolite with antithrombotic effect. N-Methylnicotinamide via production/release of prostacyclin inhibits arterial thrombosis development. N-Methylnicotinamide is also the N-methylation product from nicotinamide catalyzed by N-methyltransferase within nicotinate and nicotinamide metabolism pathway.
    N-Methylnicotinamide-d<sub>4</sub>
  • HY-N2108
    7-Ethylcamptothecin
    		99.58%
    7-Ethylcamptothecin is a derivative of Camptothecin (HY-16560) and a DNA topoisomerase I inhibitor that exhibits significant antitumor activity against tumor cells. 7-Ethylcamptothecin serves as a key precursor for the synthesis of 20 (S)-O-substituted benzoyl-7-ethylcamptothecin compounds. 7-Ethylcamptothecin is widely used in various tumor-related scientific studies.
    7-Ethylcamptothecin
  • HY-41982
    D-Glucuronic acid lactone
    		98.0%
    D-Glucuronic acid lactone (D-Glucurono-6,3-lactone; D-Glucurono-γ-lactone; D-Glucuronolactone; Dicurone; Glucoxy; Glucurolactone; Glucurone) is an endogenous metabolite and a glucuronic acid derivative. D-Glucuronic acid lactone serves as a starting reagent for the synthesis of 2,3,4-tris (tert-butyldimethylsilyl) glucuronic acid trichloroethyl ester, which is used to prepare 1-O-acyl glucuronic acids for the anti-inflammatory agent mL-3000 (HY-B1452), synthesize optically active glucuronic acids, and produce long-chain alkyl glucuronides. D-Glucuronic acid lactone shows potential for use in studies of reversible cerebral vasoconstriction syndrome (RCVS).
    D-Glucuronic acid lactone
  • HY-W008293
    Himic anhydride
    		98.0%
    Himic anhydride is an acid anhydride compound and sensitizer. Himic anhydride with cross-reactivity to hexahydrophthalic anhydride. Himic anhydride induces immunoglobulin E (IgE)-mediated sensitization and allergic immune responses. Himic anhydride can be used for the research of occupational asthma.
    Himic anhydride
  • HY-W176199
    DPPD-Q
    		≥98.0%
    DPPD-Q is a quinone derivative of p-phenylenediamine antioxidants and an analog of DTPD-Q (HY-163650). DPPD-Q is identified as a major sewage treatment plant effluent.
    DPPD-Q
  • HY-W588263
    Indole-3-acetyl glutamate
    		99.77%
    Indole-3-acetyl glutamate (IAGlu) is a derivative of the plant hormone indole-3-acetic acid (IAA). As a conjugated form of IAA, Indole-3-acetyl glutamate involves in the transport, storage, and homeostatic regulation of IAA within the plant. Indole-3-acetyl glutamate can be used for research into the effects of plant hormones on the growth and development of plants.
    Indole-3-acetyl glutamate
  • HY-W414591
    L-alpha-lysophosphatidylcholine, lauroyl
    		99.82%
    L-alpha-lysophosphatidylcholine, lauroyl (1-Lauroyl-2-hydroxy-sn-glycero-3-phosphatidylcholine) is an ester product.
    L-alpha-lysophosphatidylcholine, lauroyl