2. Signaling Pathways
  3. Anti-infection
  4. Flavivirus
  5. Flavivirus Inhibitor

Flavivirus Inhibitor

Flavivirus Inhibitors (30):

Cat. No. Product Name Effect Purity
  • HY-10396
    Emricasan
    		Inhibitor 99.59%
    Emricasan (PF 03491390) is an orally active and irreversible pan-caspase inhibitor. Emricasan inhibits Zika virus (ZIKV)-induced increases in caspase-3 activity and protected human cortical neural progenitors.
  • HY-B0421
    Mycophenolic acid
    		Inhibitor 99.63%
    Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 µM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.
  • HY-108462
    ML-SA1
    		Inhibitor 99.33%
    ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral.
  • HY-N12710
    Crenatoside
    		Inhibitor
    Crenatoside is a phenylethanol glycoside compound that can be isolated from the ethyl acetate of the tree extract of T. stans var. stans with EC50 value of 34.78 μM. Crenatoside has anti-Zika virus activity.
  • HY-18649B
    Galidesivir dihydrochloride
    		Inhibitor
    Galidesivir (BCX4430; Immucillin-A) dihydrochloride is a broad-spectrum RNA virus inhibitor that can inhibit Ebola and yellow fever virus (Flavivirus) infections. Galidesivir has potent antiviral activity against tick-borne encephalitis virus (TBEV) and also inhibits the proliferation of many other medically important flaviviruses.
  • HY-153810
    Mosnodenvir
    		Inhibitor 99.94%
    Mosnodenvir (JNJ-1802) is a pan-serotype dengue antiviral agent with a high barrier to resistance, and is safe and well-tolerated. Mosnodenvir blocks the NS3-NS4B interaction within the viral replication complex. Mosnodenvir shows picomolar to low nanomolar in vitro antiviral activity in mice.
  • HY-B1201
    Tiratricol
    		Inhibitor 99.60%
    Tiratricol is an orally available thyroid hormone analog that inhibits pituitary thyroid-stimulating hormone secretion. Tiratricol is an intracellular toxin neutralizer that inhibits LPS and lipid A cytotoxicity with IC50s of 20 μM and 32 μM, respectively. Tiratricol reduces TNF production in lipopolysaccharide-stimulated macrophages. Tiratricol also has antiviral activity and is an inhibitor of yellow fever virus (Flavivirus). It can bind to the RdRp domain of the viral NS5 protein to hinder YFV replication..
  • HY-100528
    Nanchangmycin
    		Inhibitor 99.67%
    Nanchangmycin, a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria. Nanchangmycin is a broad spectrum antiviral active against Zika virus.
  • HY-N4118
    Cephaeline
    		Inhibitor 98.94%
    Cephaeline is a phenolic alkaloid in Indian Ipecac roots. Cephaeline exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections.
  • HY-139602C
    (-)-JNJ-A07
    		Inhibitor 99.75%
    (-)-JNJ-A07 is a potent and selective DENV inhibitor with an EC50 value of 31 nM.
  • HY-16696
    SN 2
    		Inhibitor 99.16%
    SN 2 is a potent activator of TRPML3 ion channel with an EC50 of 1.8 μM. SN 2 also acts as a potent inhibitor of Dengue virus 2 (DENV2) and Zika virus (ZIKV).
  • HY-W011100
    Cyclofenil
    		Inhibitor
    Cyclofenil is a selective estrogen receptor modulator and an ovulation-inducing agent. Cyclofenil shows an inhibitory effect on dengue virus replication in Vero cells with an EC50 of 1.62 μM. Cyclofenil has anti-dengue-virus activity.
  • HY-100528A
    Dianemycin
    		Inhibitor 98.80%
    Dianemycin (Nanchangmycin free acid), a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria. Nanchangmycin is a broad spectrum antiviral active against Zika virus.
  • HY-B0421S
    Mycophenolic acid-d3
    		Inhibitor 98.95%
    Mycophenolic acid-d3 is deuterium labeled Mycophenolic acid, which is an an immunosuppresant agent and has potent anti-proliferative activity.
  • HY-144644
    NS2B/NS3-IN-3
    		Inhibitor 98.98%
    NS2B/NS3-IN-3 (Compd 66) is an inhibitor of Flavivirus NS2B-NS3 protease.
  • HY-144644A
    NS2B/NS3-IN-3 hydrochloride
    		Inhibitor 98.00%
    NS2B/NS3-IN-3 hydrochlorideis an inhibitor of Flavivirus NS2B-NS3 protease.
  • HY-N3942
    Glabranine
    		Inhibitor ≥98.0%
    Glabranine, an flavonoid, is isolated from Tephrosia s.p, exerts a inhibitory effect in vitro on the dengue virus. Glabranine forms interaction with the soluble ectodomain of DENV type 2 (DENV2) E protein.
  • HY-150234
    LabMol-319
    		Inhibitor
    LabMol-319 is a potent zika virus (ZIKV) NS5 RdRp inhibitor with an IC50 of 1.6 μM. LabMol-319 is an antiviral agent.
  • HY-136782
    ST-148 maleate
    		Inhibitor ≥99.0%
    ST-148 maleate is a potent and orally active DENV inhibitor. ST-148 maleate shows antiviral efficacy and low cell toxicity. ST-148 alters the interaction between lipid droplets and the C protein, thereby inhibiting viral replication..
  • HY-150600
    NS2B/NS3-IN-7
    		Inhibitor
    NS2B/NS3-IN-7 (compound 26) is a highly potent Zika virus NS2B-NS3 protease inhibitor with a Ki value of 2.33 nM. NS2B/NS3-IN-7 can reduce amounts of ZIKV-infected cells.