2. Signaling Pathways
  3. Epigenetics
  4. Glycosyltransferase

Glycosyltransferase

Glycosyltransferases (GTs) are key enzymes in the biosynthesis of ginsenosides, which can catalyze the transfer of glycans from donor molecules to acceptor molecules, and form a variety of biologically active glycoside compounds.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N11424
    Bilirubin diglucuronide
    		Substrate
    Bilirubin diglucuronide is a bilirubin glycoside conjugate with a 1-O-acyl β-D-glucuronide structure. Bilirubin diglucuronide is the major conjugated bilirubin (HY-N0323) and predominant pigment excreted in the bile of adult humans, rats, dogs and cats. Bilirubin diglucuronide is mainly synthesized via UDP-glucuronosyltransferase-mediated transfer of glucuronic acid from UDP-glucuronic acid to bilirubin monoglucuronide, or via enzymatic disproportionation of two moles of bilirubin monoglucuronide (predominantly producing the IXα configuration). In addition, Bilirubin diglucuronide can also be synthesized from bilirubin or its monoglucuronide in a UDP-glucuronic acid-dependent manner. Pretreatment with phenobarbital significantly enhances the formation process of Bilirubin diglucuronide.
    Bilirubin diglucuronide
  • HY-E70287
    ST6 Sialyltransferase 5
    ST6 Sialyltransferase 5 (EC:2.4.3.3, ST6GALNAC5, SIAT7E, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5) transfers a sialic acid to N-acetylgalactosamine (GalNAc) residues. ST6 Sialyltransferase 5 is a bio-marker in cervical screening samples.
    ST6 Sialyltransferase 5
  • HY-E70064A
    Helicobacter pylori alpha-1,3-fucosyltransferase
    Helicobacter pylori alpha-1,3-fucosyltransferase (Hp3FT) catalyzes the glycosyl addition of fucose from the donor GDP-fucose to the acceptor N-acetyllactosamine.
    Helicobacter pylori alpha-1,3-fucosyltransferase
  • HY-E70160
    Protein O-Fucosyltransferase 1
    Protein O-Fucosyltransferase 1 (EC:2.4.1.221; POFUT1) is a Glycosyltransferase containing the cysteine-rich motifs as the acceptor sugar and GDP-fucose as the donor.
    Protein O-Fucosyltransferase 1
  • HY-157461
    Glycation-IN-1
    Glycation-IN-1 (Compound 3) is an inhibitor of glycosylation reactions, which has a strong inhibitory effect on the synthesis of initial, intermediate, and final products of glycosylation reactions. Glycion-IN-1 can be used in the research of various chronic diseases, such as diabetes, immune inflammation, cardiovascular diseases and neurodegenerative diseases.
    Glycation-IN-1
  • HY-E70046A
    Bovine beta-1,4-Galactosyltransferase
    Bovine beta-1,4-Galactosyltransferase (Bovine B4GALT1) is a one member of the glycosyltransferase family of enzymes. Bovine beta-1,4-Galactosyltransferase transfers galactose from UDP-galactose to N-acetylglucosamine (GlcNAc) to produce N-acetyllactosamine with a β-1,4-glycosidic linkage.
    Bovine beta-1,4-Galactosyltransferase
  • HY-170663
    β-1,4-GALT1-IN-1
    		Inhibitor
    β-1,4-GALT1-IN-1 (Compound 6) is a β-1,4-GALT1 inhibitor, with an IC50 value of 6.2 μM. β-1,4-GALT1-IN-1 can be used in many pathology investigations such as cancer, autoimmune diseases and viral infections.
    β-1,4-GALT1-IN-1
  • HY-169084
    ST-IN-1
    		Inhibitor
    ST-IN-1 (compound (R)-1) is a selective ST inhibitor (Ki=70 nM, rat a-2,6-ST; Ki=19 nM, hST6GAL1) with antitumor activity. ST-IN-1 inhibits tumor growth and metastasis by delipidating the surface of tumor cells.
    ST-IN-1
  • HY-E70141
    β-1,3-N-Acetylglucosaminyltransferase 4
    β-1,3-N-Acetylglucosaminyltransferase 4 (EC:2.4.1.149, B3GNT4) is involved in the synthesis of poly-N-acetyllactosamine and has activity for type 2 oligosaccharides.
    β-1,3-N-Acetylglucosaminyltransferase 4
  • HY-156155
    GYS1-IN-1
    		Inhibitor
    GYS1-IN-1 (compound 783) is a glycogen synthase 1(GYS1) inhibitor. GYS1-IN-1 can be used for the study of GYS1 -mediated disease, such as Gaucher and Fabry diseases.
    GYS1-IN-1
  • HY-156208
    C2 Adamantanyl galactosylceramide (d18:1/2:0)
    		Substrate
    C2 Adamantanyl galactosylceramide (AdaGalCer) (d18:1/2:0) is a bioactive sphingolipid. C2 Adamantanyl galactosylceramide (d18:1/2:0) stimulates glucocerebrosidase activity in vitro. C2 Adamantanyl galactosylceramide (d18:1/2:0) inhibits microsomal LacCer and Gb3 synthase, and inhibits cell sulfatide synthesis. C2 Adamantanyl galactosylceramide (d18:1/2:0) reduces glucosylceramide (GlcCer) levels in normal and lysosomal storage disease (LSD) cells. C2 Adamantanyl galactosylceramide (d18:1/2:0) acts as a substrate for A4GALT and is able to lower Gb3 levels with an IC50 concentration of 40 μM in fabry disease cells.
    C2 Adamantanyl galactosylceramide (d18:1/2:0)
  • HY-E70154
    Fucosyltransferase 3
    Fucosyltransferase 3 (EC:2.4.1.65, FUT3, FT3B) has strong alpha 1-3 and alpha 1-4 fucosyltransferase activities.
    Fucosyltransferase 3
  • HY-E71160
    1,4-α-Glucan 6-α-glucosyltransferase
    1,4-α-Glucan 6-α-glucosyltransferase (EC 2.4.1.24) belongs to the family of glycosyltransferases, specifically the hexosyltransferases.
    1,4-α-Glucan 6-α-glucosyltransferase
  • HY-E70425
    Sucrose synthase
    Sucrose synthase belongs to glycosyltransferases and is a reversible catalyst present in plants, which catalyzes the conversion of sucrose into fructose and UDP-G or ADP-G. Sucrose synthase localizes to the cytoplasm, plasma membrane, cell wall, vacuole and mitochondria of plants. Sucrose synthase regulates sugar metabolism, supports the development of taproots, fruits, seeds and vascular tissues, drives the synthesis of starch, cellulose and callose, and enhances nitrogen fixation capacity. Sucrose synthase mediates signal transduction in plant meristems. Sucrose synthase is associated with plant growth, anaerobic stress tolerance, as well as shoot apical meristem and leaf morphology; overexpression of this enzyme promotes plant growth, increases xylem size, and elevates cellulose and starch contents.
    Sucrose synthase
  • HY-E70159
    Fucosyltransferase 11
    Fucosyltransferase 11 (EC:2.4.1.-, FUT11) links alpha-l-fucose onto conalbumin glycopeptides and biantennary N-glycan acceptors. Fucosyltransferase 11 plays an important role in cancer.
    Fucosyltransferase 11
  • HY-182408
    Endosidin7
    Endosidin7 is a specific inhibitor for plant callose deposition during cytokinesis. Endosidin7 inhibits cytokinesis-specific callose deposition at the cell plate, disrupts cell plate maturation, and alters localization of cell plate-associated proteins during late cell plate development. Endosidin7 slows root growth and induces formation of cell wall stubs in Arabidopsis thaliana seedlings.
    Endosidin7
  • HY-148596
    UDP-GlcNAc
    		Substrate
    UDP-GlcNAc (UDP-N-Acetyl-D-glucosamine) is an important component and precursor of bacterial peptidoglycan. UDP-GlcNAc is a nucleotide sugar used by Glycosyltransferases to synthesize glycoproteins, glycosaminoglycans, glycolipids, and glycoRNA. UDP-GlcNAc also serves as the donor substrate for forming O-GlcNAc, a dynamic intracellular protein modification involved in diverse signaling and disease processes. UDP-GlcNAc is the sugar nucleotide donor for the synthesis of O-GlcNAc modified proteins. UDP-GlcNAc also acts as a full agonist of the P2Y14 receptor and inhibits the formation of cAMP. UDP-GlcNAc can be used in studies related to bacterial infections.
    UDP-GlcNAc
  • HY-147960
    Glycosyltransferase-IN-1
    		Inhibitor
    Glycosyltransferase-IN-1 (compound 5m) is a potent glycosyltransferase inhibitor, with an IC50 of 82.8 μM. Glycosyltransferase-IN-1 shows antibacterial activity, with MIC values of 6 μg/mL for MSSA, MRSA, B. subtilis and 12 μg/mL for E. coli.
    Glycosyltransferase-IN-1
  • HY-175697
    Glycosyltransferase-IN-2
    		Inhibitor
    Glycosyltransferase-IN-2 (Compound 20) is a Glycosyltransferase inhibitor. Glycosyltransferase-IN-2 has a broad-spectrum anticoronavirus activity with IC50s of 11.3, 5.5 and ~16.2 μM for MHV, HCoV-NL63 and SARS-CoV-2, respectively. Glycosyltransferase-IN-2 interferes with the coronavirus infectivity, alters viral protein glycosylation with inhibition of interaction with the ACE2 receptor or SC-VLP secretion, and inhibits RNA replication. Glycosyltransferase-IN-2 can be used for coronavirus infections research.
    Glycosyltransferase-IN-2
  • HY-107366R
    SGN-2FF (Standard)
    		Inhibitor
    SGN-2FF (Standard) is the analytical standard of SGN-2FF (HY-107366). This product is intended for research and analytical applications. SGN-2FF is a potent and orally active inhibitor of fucosylation, directly inhibits fucosyltransferase activity. SGN-2FF possesses antitumor activity.
    SGN-2FF (Standard)
Cat. No. Product Name / Synonyms Application Reactivity