Molecular Glues
Protein degradation agents based on the ubiquitin-proteasome pathway include a part of molecular glues. Molecular glues are a class of small molecule compounds that can induce or stabilize the interaction between proteins. If one of the protein is ubiquitin ligase, molecular glue can cause another protein to undergo ubiquitin modification and degradation through the proteasome pathway, which is similar to PROTAC. However, these molecules are classified as ligand for E3 ligase as functional molecules in subsequent classification. Older drugs, thalidomide, lenalidomide, and pomalidomide, together with CC-90009 and CC-92480 reported later all belong to this category.
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Molecular Glues Related Products (382)
Related Products (382)
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Related Compound Screening Libraries (1)
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Mezigdomide (Standard)
0 ImagesCat. No.: HY-129395RCAS No.: 2259648-80-9Synonyms: CC-92480 (Standard)Mezigdomide (Standard) is the analytical standard of Mezigdomide (HY-129395). This product is intended for research and analytical applications. Mezigdomide (CC-92480), a cereblon E3 ubiquitin ligase modulating agent (CELMoD), acts as a molecular glue. Mezigdomide shows high affinity to cereblon, resulting in potent antimyeloma activity.
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IKZF1-degrader-1
0 ImagesCat. No.: HY-160531CAS No.: 2915586-02-4
