2. Signaling Pathways
  3. Immunology/Inflammation
  4. Mucin

Mucin

Mucin is a class of high molecular weight glycoproteins that play crucial roles in protecting and lubricating mucosal surfaces. Mucin is characterized by a large number of O-glycosylated serine and threonine residues. Mucin can be classified into secreted mucins and membrane bounded mucins. For example, MUC1 is often overexpressed in many cancers and can interact with cell surface receptors and extracellular matrix components, affecting cell adhesion, migration and signal transduction. MUC2 is the main component of intestinal mucus, forming a physical barrier to protect the intestinal epithelium from pathogens and toxins. Different mucin subtypes have distinct expression patterns and functions in various tissues and organs. Mucin can also interact with microorganisms, participating in the regulation of the host-microbe interaction[1][2].

Mucin Isoform Specific Products:

Mucin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-160062
    S2.2 aptamer sodium
    		Chemical
    S2.2 aptamer sodium is a nucleic acid-based MUC1-binding aptamer with high affinity and low toxicity. Upon binding to its target, S2.2 aptamer sodium undergoes a conformational switch and restores fluorescence signal, serving as a targeted imaging agent for MUC1-positive cancer cells. S2.2 aptamer sodium enables targeted delivery to breast cancer cells with overexpressed MUC1. When formulated as the S2.2-PEG-MZF molecular probe, S2.2 aptamer sodium possesses the functions of T2 signal inhibition, magnetic field-induced hyperthermia and targeted magnetic resonance molecular imaging. In the S2.2-PEG-MZF/DOX nanoliposome, S2.2 aptamer sodium supports targeted thermochemotherapy, effectively inhibiting cancer cell proliferation and invasion as well as inducing apoptosis, and is widely used in studies related to breast cancer.
    S2.2 aptamer sodium
  • HY-160109A
    Ac5GalNTGc epimer
    		Inhibitor 98.39%
    Ac5GalNTGc epimer is an analogue of hexosamine and the racemate of Ac5GalNTGc (HY-160109). Ac5GalNTGc is a potent, peracetylated C-2 thioglycolyl-substituted GalNAc analog that efficiently inhibits mucin-type O-glycan biosynthesis. Ac5GalNTGc reduces leukocyte sialyl-Lewis-X expression and inhibits L-/P-selectin mediated rolling under flow, as well as P-selectin dependent leukocyte-platelet adhesion. Ac5GalNTGc exhibits anti-inflammatory activity in a thioglycollate-induced acute peritonitis model. Ac5GalNTGc can be used for studies of O-glycan/mucin biology, inflammation, and related translational research.
    Ac5GalNTGc epimer
  • HY-P1925B
    L-GO-203 TFA
    		Inhibitor 98.69%
    L-GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. L-GO-203 TFA is an anti-cancer peptide for targeting intracellular proteins.
    L-GO-203 TFA
  • HY-P991608
    CTM01
    		Inhibitor
    CTM01 is a murine IgG1 (or humanized IgG4) monoclonal antibody inhibitor targeting MUC1. CTM01 has a broad spectrum anticancer activity against solid tumors of epithelial origin, such as breast, lung and ovarian cancer.
    CTM01
  • HY-P991166
    Ubletamig
    		Inhibitor
    Ubletamig is an anti-MUC16 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003).
    Ubletamig
  • HY-W009708
    Bis(2-methyl-3-furyl)disulfide
    		98.37%
    Bis(2-methyl-3-furyl)disulfide, compound (2), is intended to provide a flavoring compound to enhance a natural feeling, a fresh feeling and a milk-rich feeling of a milk-related product.
    Bis(2-methyl-3-furyl)disulfide
  • HY-B2206
    Gefarnate
    Gefarnate is a agent used for the treatment of gastritis and gastric ulcer, and has been proposed for use in the treatment of dry eye syndrome.
    Gefarnate
  • HY-136453A
    CR-1-30-B
    		Control 99.92%
    CR-1-30-B is an inactive enantiomer of CR-1-31-B. CR-1-30-B, as a control, is inactive against eIF4A and has no apparent effect on the induction of MUC1-C translation.
    CR-1-30-B
  • HY-P991649
    Anti-CA6 Antibody (huDS6)
    		98.03%
    Anti-CA6 Antibody (huDS6) is a Mucin 1-associated sialoglycotope (CA6) targeting humanized monoclonal antibody. Anti-CA6 Antibody (huDS6) can be used for synthesis of ADCs.
    Anti-CA6 Antibody (huDS6)
  • HY-158333
    Tasuldine
    		Inhibitor
    Tasuldine is a mucolytic agent, which decreases the sialomucin content of mucus, improves mucociliary and cough clearance.
    Tasuldine
  • HY-160060
    MA3 aptamer sodium
    		Chemical
    MA3 aptamer sodium is an 86-base long DNA aptamer targeting the mucin MUC1. MA3 aptamer sodium binds to the peptide epitope of mucin 1 (MUC1) with a Kd of 38.3 nM and has minimal cross-reactivity with albumin.
    MA3 aptamer sodium
  • HY-P991317
    BTH1704
    		Inhibitor
    BTH1704 is a human monoclonal antibody (mAb) targeting MUC1. BTH1704 enables PGG-primed leukocytes to kill iC3b-opsonized tumor cells. BTH1704 can be used in pancreatic and breast cancer research.
    BTH1704
  • HY-P992374
    huDMB5F3
    		Inhibitor
    huDMB5F3 (DMB5F3; chDMB5F3) is a human monoclonal antibody against human CD227/MUC1, with a Ka value of 5.89 pM for its human target. huDMB5F3 enters MUC1-positive cancer cells via a temperature-dependent internalization process. huDMB5F3 induces cytotoxicity in MUC1-positive cancer cells. huDMB5F3 can be used in the research of various cancers including breast cancer, pancreatic cancer and gastric cancer.
    huDMB5F3
  • HY-160062A
    S2.2 aptamer sodium scrambled negative control
    		Chemical
    S2.2 aptamer sodium scrambled negative control is the sequence scrambled negative control of S2.2 aptamer sodium.
    S2.2 aptamer sodium scrambled negative control
  • HY-P992096
    Pemtumomab Antibody
    		Inhibitor
    Pemtumomab Antibody (R-1549) is an anti-MUC1 monoclonal antibody. Pemtumomab Antibody can be used in research related to breast cancer and other cancers.
    Pemtumomab Antibody
  • HY-D1916
    ATTO 594
    		Ligand
    ATTO 594 is a Fluorescent dye (excitation/emission = 603/626 nm). ATTO 594 is covalently conjugated to Mucin via carbodiimide coupling.
    ATTO 594
  • HY-P991318
    AR20.5
    		Inhibitor
    AR20.5 is a human monoclonal antibody (mAb) targeting MUC1. AR20.5 increases the number of activated CD8 T cells, CD3+CD4−CD8−(DN) T cells, and mature dendritic cells in pancreatic tumor-bearing mice. AR20.5 can be used in anti-pancreatic cancer immunity research.
    AR20.5
  • HY-P992373
    huCC49
    		Inhibitor
    huCC49 is a human monoclonal antibody targeting TAG-72. huCC49 can be used in cancer-related research. The recommended isotype control is human IgG1 kappa, with the isotype control (HY-P99001).
    huCC49
  • HY-160060A
    MA3 aptamer sodium scrambled negative control
    		Chemical
    MA3 aptamer sodium scrambled negative control is the sequence scrambled negative control of MA3 aptamer sodium.
    MA3 aptamer sodium scrambled negative control
  • HY-P990830
    Anti-MUC16 Antibody (VK8)
    		Inhibitor
    Anti-MUC16 Antibody (VK8) is a kind of mouse IgG1 κ chimeric antibody inhibitor, targeting to human MUC16. Anti-MUC16 Antibody (VK8) reacts with human MUC16 also known as carbohydrate antigen 125 (CA125). Anti-MUC16 Antibody (VK8) Anti-MUC16 Antibody (VK8) can be used for detection of tumor marker, such as ovarian cancer.
    Anti-MUC16 Antibody (VK8)
Cat. No. Product Name / Synonyms Application Reactivity
Mucin Isoform Comparison

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