Mucin
Mucin is a class of high molecular weight glycoproteins that play crucial roles in protecting and lubricating mucosal surfaces. Mucin is characterized by a large number of O-glycosylated serine and threonine residues. Mucin can be classified into secreted mucins and membrane bounded mucins. For example, MUC1 is often overexpressed in many cancers and can interact with cell surface receptors and extracellular matrix components, affecting cell adhesion, migration and signal transduction. MUC2 is the main component of intestinal mucus, forming a physical barrier to protect the intestinal epithelium from pathogens and toxins. Different mucin subtypes have distinct expression patterns and functions in various tissues and organs. Mucin can also interact with microorganisms, participating in the regulation of the host-microbe interaction[1][2].
References:
- [1]. Dhanisha SS, et al. Mucins: Structural diversity, biosynthesis, its role in pathogenesis and as possible therapeutic targets. Crit Rev Oncol Hematol. 2018 Feb;122:98-122. [Content Brief]
- [2]. Corfield AP. Mucins: a biologically relevant glycan barrier in mucosal protection. Biochim Biophys Acta. 2015 Jan;1850(1):236-52. [Content Brief]
Mucin Isoform Specific Products
All Product Categories
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Mucin Related Products (41)
Related Products (41)
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Antibodies (9)
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Mucin Isoform Comparison
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S2.2 aptamer sodium
0 ImagesCat. No.: HY-160062S2.2 aptamer sodium is a nucleic acid-based MUC1-binding aptamer with high affinity and low toxicity. Upon binding to its target, S2.2 aptamer sodium undergoes a conformational switch and restores fluorescence signal, serving as a targeted imaging agent for MUC1-positive cancer cells. S2.2 aptamer sodium enables targeted delivery to breast cancer cells with overexpressed MUC1. When formulated as the S2.2-PEG-MZF molecular probe, S2.2 aptamer sodium possesses the functions of T2 signal inhibition, magnetic field-induced hyperthermia and targeted magnetic resonance molecular imaging. In the S2.2-PEG-MZF/DOX nanoliposome, S2.2 aptamer sodium supports targeted thermochemotherapy, effectively inhibiting cancer cell proliferation and invasion as well as inducing apoptosis, and is widely used in studies related to breast cancer.
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Ac5GalNTGc epimer
0 ImagesAc5GalNTGc epimer is an analogue of hexosamine and the racemate of Ac5GalNTGc (HY-160109). Ac5GalNTGc is a potent, peracetylated C-2 thioglycolyl-substituted GalNAc analog that efficiently inhibits mucin-type O-glycan biosynthesis. Ac5GalNTGc reduces leukocyte sialyl-Lewis-X expression and inhibits L-/P-selectin mediated rolling under flow, as well as P-selectin dependent leukocyte-platelet adhesion. Ac5GalNTGc exhibits anti-inflammatory activity in a thioglycollate-induced acute peritonitis model. Ac5GalNTGc can be used for studies of O-glycan/mucin biology, inflammation, and related translational research.
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CTM01
0 ImagesCat. No.: HY-P991608Purity: 99.32%Synonyms: 7F11C7CTM01 is a murine IgG1 (or humanized IgG4) monoclonal antibody inhibitor targeting MUC1. CTM01 has a broad spectrum anticancer activity against solid tumors of epithelial origin, such as breast, lung and ovarian cancer.
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Bis(2-methyl-3-furyl)disulfide
0 ImagesBis (2-methyl-3-furyl) disulfide is a meat-characteristic aroma compound that binds to oral mucins. Bis (2-methyl-3-furyl) disulfide interacts with oral mucins via hydrogen bonding, hydrophobic interactions and van der Waals forces to form stable spontaneous 1:1 complexes, and the interaction strength varies with pH. Bis (2-methyl-3-furyl) disulfide contributes to the production of unique meat aroma and flavor, and its binding to oral mucins alters aroma perception.
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Gefarnate
0 ImagesGefarnate is a agent used for the treatment of gastritis and gastric ulcer, and has been proposed for use in the treatment of dry eye syndrome.
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huCC49
0 ImagesCat. No.: HY-P992373
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CR-1-30-B
0 ImagesCR-1-30-B is an inactive enantiomer of CR-1-31-B. CR-1-30-B, as a control, is inactive against eIF4A and has no apparent effect on the induction of MUC1-C translation.
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Anti-CA6 Antibody (huDS6)
0 ImagesCat. No.: HY-P991649Purity: 98.03%Synonyms: SAR566658 antibodyAnti-CA6 Antibody (huDS6) is a Mucin 1-associated sialoglycotope (CA6) targeting humanized monoclonal antibody. Anti-CA6 Antibody (huDS6) can be used for synthesis of ADCs.
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Tasuldine
0 ImagesCat. No.: HY-158333CAS No.: 88579-39-9Tasuldine is a mucolytic agent, which decreases the sialomucin content of mucus, improves mucociliary and cough clearance.
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Guaimesal
0 ImagesCat. No.: HY-W746270CAS No.: 81674-79-5Synonyms: BrontermilGuaimesal is a new antiphlogistic and mucus-regulating agent. Guaimesal improves bronchitis symptoms.
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BTH1704
0 ImagesCat. No.: HY-P991317
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Bis(2-methyl-3-furyl)disulfide (Standard)
0 ImagesCat. No.: HY-W009708RCAS No.: 28588-75-2Bis(2-methyl-3-furyl)disulfide (Standard) is the analytical standard of Bis(2-methyl-3-furyl)disulfide. This product is used for research and analytical applications. Bis(2-methyl-3-furyl)disulfide is a meat flavor characteristic aroma compound that can bind to oral mucin. Bis(2-methyl-3-furyl)disulfide can interact with oral mucin through hydrogen bonds, hydrophobic interactions, and van der Waals forces to form a stable spontaneous 1:1 complex, and the interaction intensity varies with pH. Bis(2-methyl-3-furyl)disulfide helps to produce unique meat aroma and flavor, and its binding to oral mucin will change the perception of aroma.
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huDMB5F3
0 ImagesCat. No.: HY-P992374Synonyms: DMB5F3; chDMB5F3huDMB5F3 (DMB5F3; chDMB5F3) is a human monoclonal antibody against human CD227/MUC1, with a Ka value of 5.89 pM for its human target. huDMB5F3 enters MUC1-positive cancer cells via a temperature-dependent internalization process. huDMB5F3 induces cytotoxicity in MUC1-positive cancer cells. huDMB5F3 can be used in the research of various cancers including breast cancer, pancreatic cancer and gastric cancer.
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S2.2 aptamer sodium scrambled negative control
0 ImagesCat. No.: HY-160062AS2.2 aptamer sodium scrambled negative control is the sequence scrambled negative control of S2.2 aptamer sodium.
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ATTO 594
0 ImagesCat. No.: HY-D1916CAS No.: 1253909-75-9ATTO 594 is a Fluorescent dye (excitation/emission = 603/626 nm). ATTO 594 is covalently conjugated to Mucin via carbodiimide coupling.
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MA3 aptamer sodium scrambled negative control
0 ImagesCat. No.: HY-160060AMA3 aptamer sodium scrambled negative control is the sequence scrambled negative control of MA3 aptamer sodium.
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Anti-MUC16 Antibody (VK8)
0 ImagesCat. No.: HY-P990830Anti-MUC16 Antibody (VK8) is a kind of mouse IgG1 κ chimeric antibody inhibitor, targeting to human MUC16. Anti-MUC16 Antibody (VK8) reacts with human MUC16 also known as carbohydrate antigen 125 (CA125). Anti-MUC16 Antibody (VK8) Anti-MUC16 Antibody (VK8) can be used for detection of tumor marker, such as ovarian cancer.
