2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Orphan Nuclear Receptor
  5. Orphan Nuclear Receptor Modulator

Orphan Nuclear Receptor Modulator

Orphan Nuclear Receptor Modulators (4):

Cat. No. Product Name Effect Purity
  • HY-135572
    TLX agonist 1
    		Modulator 99.94%
    TLX agonist 1 (ccrp2) is an orphan nuclear receptor tailless (TLX, NR2E1) modulator (EC50=1μM; Kd= 650 nM). TLX agonist 1 potentiates TLX transcriptional repressive activity.
  • HY-147105A
    (+)-LRH-1 agonist-2
    		Modulator 99.38%
    (+)-LRH-1 modulator-1 is a stereoisomer of LRH-1 modulator-1. LRH-1 modulator-1 (compound 6N) is a potent LRH-1 (liver receptor homolog-1) modulator/agonist. LRH-1 modulator-1 has anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 induces the anti-inflammatory cytokine IL-10 and reduces the inflammatory cytokines IL-1b and TNFa.
  • HY-W649594
    NR2F6 modulator-2
    		Modulator 99.46%
    NR2F6 modulator-2 (Compound I) is an autorepressed orphan nuclear receptor NR2F6 (Nuclear Receptor subfamily 2 group F member 6) modulator. NR2F6 modulator-2 can inhibits the recruitment of the bio-NSD1 peptide with an IC50 of 2.0 equivalents of NR2F6. NR2F6 modulator-2 can be used for the researches of cancer and immunology.
  • HY-118912
    BMH-9
    		Modulator
    BMH-9 (Compound Z54) is a modulator for nuclear receptor subfamily 2, group F, member 6 (NR2F6) (also known as nuclear orphan receptor Ear2). BMH-9 is an activator for p53 signaling pathway through interaction with DNA. BMH-9 inhibits proliferation of human cancer cells, exhibits antitumor efficacy in NOD-SCID mouse models.