Prion Protein
Prion Protein is a protein that is converted from a normal cell protein (PrPC) to a pathogenic conformation (PrPSc). PrPC is an α-helices rich membrane glycoprotein, which regulates neuronal development, synaptic function, intercellular signaling, cellular oxidative stress response, and apoptosis under normal physiological conditions. PrPC is converted into β-folding rich PrPSc under pathological conditions, leading to neuronal damage and death. Prion Protein dysfunction and misfolding causes prion diseases such as Creutzfeldt-Jakob Disease (CJD), Fatal Familial Insomnia (FFI), Gerstmann-Sträussler-Scheinker Syndrome (GSS), and other neurodegenerative diseases such as Alzheimer's Disease (AD), Parkinson's Disease (PD) or Multiple System Atrophy (MSA)[1].
All Product Categories
-
Prion Protein Related Products (22)
Related Products (22)
- 1
- 2
-
6-Amino-8-trifluoromethylphenanthridine
0 ImagesCat. No.: HY-134561CAS No.: 651055-83-3Synonyms: 6A-8tFP6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine (HY-135189). It inhibits protein folding activity of the ribosome (PFAR) when used at a concentration of 150 μM.2 6A-8tFP directly competes with protein substrates for the ribosomal active site.
-
PRN100
0 ImagesCat. No.: HY-P991957PRN100 is a fully humanized anti-prion protein (PrPᶜ) monoclonal antibody belonging to the IgG4κ isotype. By binding to and stabilizing cellular prion protein, PRN100 aims to prevent the recruitment and conversion of cellular prion protein into pathogenic, self-propagating prion (PrPˢᶜ) aggregates. PRN100 can be used for the research of Creutzfeldt-Jakob disease.
- 1
- 2
