2. Signaling Pathways
  3. Immunology/Inflammation
  4. TREM receptor
  5. TREM receptor Activator

TREM receptor Activator

TREM receptor Isoform Comparison

TREM receptor Activators (3):

Cat. No. Product Name Effect Purity
  • HY-P991905
    AL044
    		Activator
    AL044 is an antibody targeting MS4A family proteins. AL044 can mimic the protective effects of MS4A gene variants, thereby increasing the expression of both sTREM2 and membrane-bound TREM2 in cells. AL044 is applicable for research on Alzheimer's disease.
  • HY-W010270A
    Aurothiomalate disodium
    		Activator
    Aurothiomalate (disodium) is a TRPA1 inhibitor. Aurothiomalate (disodium) inhibits NF-κB activation and iNOS expression. Aurothiomalate (disodium) promotes M2 transformation of macrophages and increases the expression of TREM-2 and arginase-1. Aurothiomalate (disodium) can be used in the study of liver fibrosis/cirrhosis and arthritis.
  • HY-N9164
    Hecubine
    		Activator
    Hecubine is a monoterpene indole alkaloid found in Ervatamia ocinalis. Hecubine activates TREM2 expression, reduces LPS (HY-D1056)-stimulated inammatory cytokines (TNF-α、IL-6、IL-1β) overexpression, as well as suppresses the levels of TLR4-, MyD88-, MAPK/PI3K/AKT- and NF-κB-related proteins. Hecubin also exhibits antioxidative effect, reduces ROS production and activates of the Nrf2/HO-1 pathway. Hecubine rescues LPS-induced behavioral deficits in zebrash larvae. Hecubine can be used for the research of neural inflammation-associated central nervous system diseases.