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Voclosporin (Synonyms: ISAtx-247)

製品番号: HY-106638 純度: 99.20%
取扱説明書

Voclosporin is a calcineurin (CN) inhibitor.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用としては使用しないように、十分ご注意ください。

Voclosporin 構造式

Voclosporin 構造式

CAS 番号 : 515814-01-4

容量 価格(税別) 在庫状況 数量
10 mM * 1  mL in DMSO USD 1269 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 650 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 950 在庫あり
Estimated Time of Arrival: December 31
25 mg USD 1950 在庫あり
Estimated Time of Arrival: December 31
50 mg USD 2950 在庫あり
Estimated Time of Arrival: December 31
100 mg USD 4400 在庫あり
Estimated Time of Arrival: December 31
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

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製品説明

Voclosporin is a calcineurin (CN) inhibitor.

IC50 & Target

Calcineurin[1]

体外実験

This novel semi-synthetic calcineurin (CN) inhibitor is designated Voclosporin (ISATX247). The efficacy of Voclosporin as an immunosuppressive agent is examined using an in vitro calcineurin assay[1]. Voclosporin (ISATX247) is a calcineurin inhibitor that has shown more potency than Cyclosporine in vitro[2].

体内実験

All animals tolerate Voclosporin (ISATX247) and Cyclosporine A (CsA) very well. There are no severe adverse effects associated with either drug. In the Voclosporin group, all animals except 1 have diarrhea of different durations during the study (mean 2.3 days, range 2 to 7 days). This differs from the CsA and the control groups, where no animals have diarrhea. Mean weight loss at the end of the study is slightly higher in the Voclosporin group than in the CsA and control groups (3.4% vs 2.0% and 1.0%, respectively)[2].

臨床実験
分子量

1214.62

分子式

C₆₃H₁₁₁N₁₁O₁₂

CAS 番号

515814-01-4

SMILES

C=C/C=C/C[[email protected]@H](C)[[email protected]]([[email protected]]1([H])N(C([[email protected]](N(C([[email protected]@H](N(C([[email protected]](N(C([[email protected]](NC([[email protected]@H](NC([[email protected]](CC(C)C)N(C)C([[email protected]@](C(C)C)([H])NC([[email protected]](CC(C)C)N(C)C(CN(C)C([[email protected]](CC)NC1=O)=O)=O)=O)=O)=O)C)=O)C)=O)C)([H])CC(C)C)=O)C)CC(C)C)=O)C)([H])C(C)C)=O)C)O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : ≥ 50 mg/mL (41.17 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8233 mL 4.1165 mL 8.2330 mL
5 mM 0.1647 mL 0.8233 mL 1.6466 mL
10 mM 0.0823 mL 0.4117 mL 0.8233 mL
*Please refer to the solubility information to select the appropriate solvent.
体内:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.06 mM); Clear solution

*All of the co-solvents are provided by MCE.
参考文献
動物実験
[2]

Monkey[2]
Wild-caught, male cynomolgus monkeys, weighing between 5 and 8 kg, are used. Four groups of animals are treated twice daily at 8:00 AM and 6:00 PM for 7 days with the following doses: Group I (n=6), Voclosporin 25 mg/kg; Group II (n=6), Voclosporin 50 mg/kg; Group III (n=5), CsA 25 mg/kg; and Group IV (n=4), vehicle (no drug) 1 mL/kg. Levels of Cyclosporine and Voclosporin in whole blood are measured by liquid chromatography/mass spectrometry[2].

MCE はこれらの方法の精度を確認していません。 こちらは参照専用です。

参考文献
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

VoclosporinISAtx-247ISAtx247ISAtx 247OthersInhibitorinhibitorinhibit

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製品名:
Voclosporin
製品番号:
HY-106638
数量:
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